Clinical trials: Overload
Fluid Therapy, Postoperative Period
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics.
- Conditions
- Fluid Therapy, Postoperative Period, Postoperative Complications, Pancreas Disease
- Trial name
- NCT03553394
- Testing
- Ringer's Acetate
- Where
- Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Kidney Disease, Peritoneal Dialysis (PD)
Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)
To explore the use of the Bodyport Cardiac Scale in predicting worsening of events due to fluid overload in patients with kidney disease on peritoneal dialysis.
- Conditions
- Kidney Disease, Peritoneal Dialysis (PD), End Stage Kidney Disease (ESRD)
- Trial name
- SCALE-PD (NCT07059962)
- Testing
- Bodyport Cardiac Scale
- Where
- 7 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Bodyport Inc.
Sickle Cell Anemia, Sickle Cell Thalassemia
Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia
Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients.
- Trial name
- NCT00512564
- Testing
- Laboratory analyses of iron overload
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Iodine Overload in Pregnancy
Registry Study for Pregnant Women With Iodine Overload
Pre-gestational performance of hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium has been demonstrated to be the main cause of excessive iodine exposure for pregnant women.
- Trial name
- NCT03470597
- Testing
- dietary iodine restriction on subjects with iodine overload
- Volunteers
- 195 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Iron Overload
Pharmacokinetic Study of Deferiprone in Paediatric Patients
Deferiprone (DFP) is the most extensively studied oral iron chelator to date. It has been authorised in Europe in 1999 for the treatment of iron overload in patients with beta-thalassaemia major when DFO is contraindicated or…
- Trial name
- DEEP-1 (NCT01740713)
- Testing
- Deferiprone, dose level 1, Deferiprone, dose level 2, Deferiprone, dose level 3
- Where
- 7 sites in Cyprus, Egypt and 1 more
- Volunteers
- 23 people
- Sponsor
- Consorzio per Valutazioni Biologiche e Farmacologiche
β-thalassemia, Transfusional Iron Overload
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload
The primary purpose of this study is to evaluate the effect of deferasirox on renal hemodynamics by determining glomerular filtration rate (GFR), renal plasma flow (RPF) and filtration fraction (FF).
- Trial name
- NCT00560820
- Testing
- Deferasirox
- Where
- 3 sites in Italy
- Volunteers
- 11 people
- Sponsor
- Novartis Pharmaceuticals
Fluid Overload Pulmonary Edema, Peritoneal Dialysis Complication
Assessing Fluid Status of Peritoneal Dialysis Patients With Assistance of Lung Ultrasound
As studied previously, lung congestion is very prevalent however usually asymptomatic in dialysis patients. Fluid overload is associated with hospitalizations, worse cardiovascular outcomes and mortality in PD patients.
- Trial name
- Fluid-PLUS (NCT04176627)
- Testing
- Lung ultrasound
- Where
- 16 sites in United States
- Volunteers
- 44 people
- Sponsor
- Satellite Healthcare
Subchondral Insufficiency Fracture
Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee
The OSSIOfiber® Trimmable Fixation Nails are indicated for maintenance of alignment and fixation of bone fractures, osteotomies, arthrodesis and bone grafts in the presence of appropriate additional immobilization (e.g., rigid…
- Trial name
- NCT06138548
- Testing
- Ossiofiber® Trimmable Fixation Nail
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Iron Overload, Iron Deficiency
Study of the Effects of Muscular Activity on Iron Metabolism
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be…
- Trial name
- NCT00378469
- Testing
- 45 minute exercise on ergocycle
- Where
- 2 sites in France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Hemochromatosis
Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent Patients
Systematical (retro- and prospective) investigation of the long-term safety (toxicity assessment according to CTCAE v3.0) and efficacy of deferiprone either given alone or in combination with desferrioxamine
- Trial name
- NCT00349453
- Testing
- Deferiprone (L1), Desferrioxamine
- Where
- 13 sites in Switzerland
- Volunteers
- 24 people
- Sponsor
- Lipomed
Cardiopulmonary Bypass Surgery, Aortic Valve Surgery
Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass
Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Conditions
- Cardiopulmonary Bypass Surgery, Aortic Valve Surgery, Mitral Valve Surgery, Myocardial Revascularization Surgery With Extracorporeal Circulation
- Trial name
- NCT07212842
- Testing
- Methylene Blue, Conventional ultrafiltration, Zero-balance ultrafiltration
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo
Autism, Autism Spectrum Disorder
The Impact of Sensory Integration on Attention in Autism
The study aims to examine how the mode of presentation of visual and auditory stimuli-separate or simultaneous-affects accuracy and reaction time in visual-auditory association in participants with Autism Spectrum Condition (ASC)…
- Trial name
- NCT06872229
- Testing
- Autism Spectum Conditions - intervention, Typical Development - intervention
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Sickle Cell Disease
Iron Mediated Vascular Disease in Sickle Cell Anemia Patients
The purpose of this research study is to determine the frequency and severity of iron overload in patients with Sickle Cell Anemia and its relationship to blood vessel function.
- Trial name
- NCT01239901
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Los Angeles
Fluid Overload, Organ Edema
"The Effect of Reduced Fluid Load After Cardiac Surgery"
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time.
- Conditions
- Fluid Overload, Organ Edema, Organ Function
- Trial name
- NCT01438502
- Testing
- HyperHAES® (hypertonic saline/HES)
- Sponsor
- Haukeland University Hospital
Hereditary Hemochromatosis
PTG-300 in Subjects With Hereditary Hemochromatosis
This study will be conducted at multiple sites and every patient will get treated with PTG-300. The objective of the study is to assess the effect of PTG-300 in treating adult hereditary hemochromatosis patients.
- Trial name
- NCT04202965
- Testing
- PTG-300
- Where
- 11 sites in United States, Canada
- Volunteers
- 16 people
- Sponsor
- Protagonist Therapeutics, Inc.
Heart Failure, Ventricular Tachycardia
Compare Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Effect on Heart Failure
This pilot study is to prospectively evaluate the benefit of clinicians being able to access ICD device information in a timelier manner and treat fluid overload with a pre-defined pattern using the Medtronic OptiVol, Medtronic…
- Conditions
- Heart Failure, Ventricular Tachycardia, Cardiac Desynchronization
- Trial name
- ConnectOptiVol (NCT00730548)
- Testing
- Device triggered remote telephone contact because of Care Alert
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Hyponatremia, Hypernatremia
Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Children who are undergoing surgery need intravenous fluids to prevent dehydration and maintain their electrolyte balance. The current standard of care in these children is to use a fluid which is low in sodium (hypotonic fluid).
- Trial name
- NCT00734214
- Testing
- 0.9% NaCl, 0.45%NaCl
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Fluid Overload, Fluid Loss
Peroperative Fluid Management in Major Gynecological Cancer Surgeries
The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries.
- Conditions
- Fluid Overload, Fluid Loss, Perioperative/Postoperative Complications, Acute Kidney Injury
- Trial name
- NCT06101498
- Testing
- Akut kidnet injury(AKI)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Obesity
Study About High Fat Meal and Postprandial Lipemia
The hypothesis of the proposed project is that after a fat overload, the postprandial response is different in both groups, suggesting that the LPP will present the most significant damage in endothelial vasomotion in obese…
- Trial name
- NCT01692327
- Testing
- High fat meal
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Caregiver Burnout
"Dialogue Circles" to Reduce the Level of Caregiver Overload in Complex Chronic Patients and Advanced Chronic Disease
The increase in life expectancy and the decrease in the birth rate have led to an aging population and a higher prevalence of chronic diseases.
- Trial name
- NCT04993248
- Testing
- Dialog Circle
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina