Clinical trials: Overactive Bladder Syndrome
Overactive Bladder (OAB), Overactive Bladder Syndrome
Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study
Researchers are studying two medicines to see which works better for women with overactive bladder (OAB). OAB causes sudden urges to urinate, frequent bathroom trips, and sometimes leakage.
- Trial name
- WoMEN'S (NCT07416968)
- Testing
- Tadalafil 5 mg, Solifenacin 5mg
- Where
- 14 sites in Egypt
- Volunteers
- 480 people
- Sponsor
- Mansoura University
Overactive Bladder Syndrome
Role of Combination Therapy in Women With Refractory Overactive Bladder
Defined by the International Continence Society (ICS) as urinary "urgency, with or without urge incontinence, usually with frequency and nocturia", overactive bladder (OAB) presents as challenging syndrome to treat.
- Trial name
- NCT06438861
- Testing
- Vibegron 75mg
- Sponsor
- University of Alabama at Birmingham
Urge Incontinence, Urgency-frequency Syndrome
Percutaneous Nerve Evaluation Trial Time
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998.
- Conditions
- Urge Incontinence, Urgency-frequency Syndrome, Overactive Bladder
- Trial name
- NCT06226220
- Testing
- Sacral neuromodulation
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Overactive Bladder Syndrome, Neuropathic Bladder
Oxybutynin for Post-surgical Bladder Pain and Urgency
Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.
- Trial name
- NCT03952299
- Testing
- Oxybutynin Transdermal Patch, Oral Oxybutynin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Multiple Sclerosis, Overactive Bladder Syndrome
Effect of TTNS and PNS on Neurogenic Overactive Bladder Symptoms in Female Patients With Multiple Sclerosis.
This study aims to evaluate the use of transcutaneous tibial nerve stimulation (TTNS) and parasacral nerve stimulation (PSS) methods in the treatment of overactive bladder (OAB) symptoms in patients with Multiple Sclerosis (MS)…
- Trial name
- NCT06143397
- Testing
- TTNS (Transcutaneous tibial nerve stimulation), PNS (Parasacral nerve stimulation), Behavioral treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Overactive Bladder Syndrome
Oral Lactobacillus Supplementation as Treatment for Overactive Bladder Syndrome: A Randomised Controlled Trial
Background: Overactive bladder describes a syndrome characterized by frequent urges to urinate and increased urination with or without nocturia and with or without urinary incontinence.
- Trial name
- NCT06546189
- Testing
- OMNi BiOTiC® 41167
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Overactive Bladder Syndrome, Urinary Urge Incontinence
Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial
Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine.
- Conditions
- Overactive Bladder Syndrome, Urinary Urge Incontinence, Detrusor Overactivity
- Trial name
- NCT07184307
- Testing
- Platelet-Rich Plasma, Intravesical Botulinum Toxin Injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Benha University
Overactive Bladder Syndrome, Overactive Bladder (OAB)
Home-Based Transcutaneous Remotely Monitored Posterior Tibial Neuromodulation
To record the T-PTNS device (SmartUric) treatment performed by the patient at home via a mobile application in a remotely monitorable, secure and interactive manner with registration notes and a sham control group.
- Conditions
- Overactive Bladder Syndrome, Overactive Bladder (OAB), Transcutaneous Posterior Tibial Nerve Stimulation (TTNS)
- Trial name
- TRIP-HOME (NCT07081412)
- Testing
- Efficacy of remotely monitored transcutaneous posterior tibial nerve neuromodulation via a test device at 12 week and 12 month
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ege University
Overactive Bladder Syndrome
Prevalence And Risk Factors of Overactive Bladder Syndrome Among Egyptian Medical Students, and Their Impact On Health-Related Quality Of Life
Overactive bladder (OAB) is defined as sudden, urgent desire to urinate (urgency) accompanied by frequency and nocturia, with or without urgent urinary incontinence in the absence of urinary tract infection (UTI).
- Trial name
- NCT07044778
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Overactive Bladder Syndrome
Study of V117957 in Overactive Bladder Syndrome
The purpose of this study is to evaluate the safety, tolerability and efficacy of V117957 in subjects with overactive bladder syndrome, compared to placebo.
- Trial name
- NCT06024642
- Testing
- V117957
- Where
- 12 sites in United States
- Volunteers
- 51 people
- Sponsor
- Imbrium Therapeutics
Overactive Bladder, Urgency-frequency Syndrome
TEST-ON - Does iStim Reduce Urinary Urgency?
Overactive bladder (OAB) is a chronic disorder with an overall prevalence in the adult population of over 10%, but that may exceed 40% in elderly groups.
- Conditions
- Overactive Bladder, Urgency-frequency Syndrome, Urinary Frequency More Than Once at Night
- Trial name
- TEST-ON (NCT04957524)
- Testing
- iStim TENS unit and Transvaginal Probe
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lower Urinary Tract Symptoms, Female Genitourinary Disease
Efficacy of Vaginal 17β-Estradiol on the Urinary Storage Symptoms in Postmenopausal Women
The goal of this clinical trial is to evaluate whether vaginal 17β-estradiol effectively treats storage symptoms of lower urinary tract symptoms (LUTS) and enhances quality of life.
- Conditions
- Lower Urinary Tract Symptoms, Female Genitourinary Disease, Urinary Stress Incontinence, Urinary Urge Incontinence
- Trial name
- NCT06508944
- Testing
- vaginal 17 beta-estradiol, Behavioral modifications
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University
Overactive Bladder Syndrome, Urinary Incontinence, Urge
Effectiveness of Bilateral PTNS Compared to Unilateral PTNS for the Treatment of Overactive Bladder/Urge Incontinence
This study is designed to evaluate whether bilateral Posterior Tibial Nerve Stimulation is more effective than unilateral Posterior Tibial Nerve Stimulation at treating overactive bladder and urge urinary incontinence
- Trial name
- BUTTON (NCT03535857)
- Testing
- PTNS
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Gnankang Sarah Napoe
Overactive Bladder Syndrome, Urinary Urge Incontinence
Cycling Study With the Axonics System
A prospective, multi-center, study comparing continuous sacral neuromodulation (SNM) stimulation to daily cyclic stimulation of 2 hours "on" and 22 hours "off" using the Axonics System.
- Conditions
- Overactive Bladder Syndrome, Urinary Urge Incontinence, Sacral Neuromodulation
- Trial name
- NCT05543382
- Testing
- Axonics System
- Where
- 6 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Axonics, Inc.
Overactive Bladder Syndrome
Transvaginal Detrusor Nerve Radiofrequency Ablation for Treatment of Overactive Bladder
The goal of this Safety and efficacy of transvaginal Detrusor Nerve Ablation for treatment of overactive bladder symptoms, including refractory overactive bladder The main questions it aims to answer are: •Change from baseline to…
- Trial name
- NCT06283498
- Testing
- Device Morpheus8V
- Where
- 3 sites in United States, Colombia
- Volunteers
- 32 people
- Sponsor
- InMode MD Ltd.
Overactive Bladder, Overactive Detrusor
Minimizing Pain During Office Intradetrussor Botox Injection
This will be a prospective double-blinded randomized controlled trial comparing two pre-treatment protocols for patients undergoing intradetrussor botox injections to determine if a buffered lidocaine solution offers superior…
- Conditions
- Overactive Bladder, Overactive Detrusor, Overactive Bladder Syndrome, Overactivity; Behavior
- Trial name
- NCT04270526
- Testing
- Bicarbonate protocol, Standard protocol
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Boston Urogynecology Associates
Overactive Bladder, Bladder Pain Syndrome
Bladder Botox UTI Antibiotic Prophylaxis
Overactive bladder (OAB) is a common condition with a prevalence of 17% in the general population that significantly affects quality of life.
- Trial name
- NCT06387329
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Overactive Bladder Syndrome, Refractory Overactive Bladder
Comparing Treatments for Refractory Overactive Bladder: Bladder Denervation vs Botulinum Toxin Injections
The goal of this clinical trial is to compare the effectiveness and safety of two treatments for refractory overactive bladder in adult women.
- Trial name
- SBD-BOT-OAB (NCT06796855)
- Testing
- Selective Bladder Denervation via Radiofrequency Ablation, Intravesical Onabotulinum Toxin A Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bagcilar Training and Research Hospital
Overactive Bladder Syndrome
Overactive Bladder Syndrome and Hypopressive Exercise
Overactive Bladder Syndrome (OAB) is a condition characterized by a sudden and urgent need to urinate, with or without urge incontinence, accompanied by increased urinary frequency.
- Trial name
- NCT06780657
- Testing
- Online hypopressive exercise training program
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Pamukkale University