Clinical trials: Otorhinolaryngologic Diseases
Dysphagia
Adjunctive Neuromuscular Electrical Stimulation for the Rehabilitation of Swallowing
Neuromuscular Electrical stimulation (NMES) for swallowing has recently been proposed for the treatment of dysphagia post stroke and is clinically receiving favor as a treatment modality, in the absence of strong research…
- Trial name
- ANSRS (NCT01279824)
- Testing
- swallowing therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Hearing Loss, Sensorineural
Fitting Strategy Study
To be conducted with adult participants with mild-to-moderate hearing loss to validate the effectiveness of the Web App fitting strategy.
- Trial name
- NCT04972162
- Testing
- Web App Strategy Fitting, Standard-of-care Fitting
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- WSAUD A/S
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies
The purpose of this study is to evaluate the safety and tolerability, and determine the maximum tolerated dose of INCB062079 in subjects with advanced hepatocellular carcinoma and other malignancies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Esophageal Cancer, Nasopharyngeal Cancer
- Trial name
- NCT03144661
- Testing
- INCB062079
- Where
- 6 sites in United States, Belgium
- Volunteers
- 25 people
- Sponsor
- Incyte Corporation
Dysphagia
PRO-ACTIVE: Prophylactic Swallow Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer
Dysphagia (difficulty swallowing) is a common and potentially life-threatening toxicity of radiotherapy (RT) for patients with head and neck cancer (HNC).
- Trial name
- PRO-ACTIVE (NCT03455608)
- Testing
- RE-ACTIVE, PRO-ACTIVE EAT, PRO-ACTIVE EAT + EXERCISE
- Where
- 13 sites in United States, Canada
- Volunteers
- 952 people
- Sponsor
- University Health Network, Toronto
Hoarseness of Voice, Sore-throat
A Prospective,Randomised, Open Label Study for Comparison of the Incidence and Severity of Postoperative Sore Throat (POST) Using C-MAC Video Laryngoscope and Traditional Macintosh Laryngoscope for Intubation
The aim of this study is to compare the incidence of postoperative sore throat after intubation with two different types of laryngoscopes.
- Trial name
- NCT05531617
- Testing
- Intubation
- Where
- India
- Volunteers
- 54 people
- Sponsor
- Seth Gordhandas Sunderdas Medical College
Sensorineural Hearing Loss
Efficacy of Digital Noise Reduction Strategies: A Hearing Aid Trial
The purpose of this study is to see if noise reduction programs in digital hearing aids help patients hear better than hearing aids without these programs.
- Trial name
- NCT00261768
- Testing
- Digital noise reduction
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- US Department of Veterans Affairs
Rhinitis, Allergic, Perennial
Fexofenadine Study On Filipino Children for The Relief of Perennial And Intermittent Allergic Rhinitis
To determine the safety and efficacy of Fexofenadine (Telfast®) 30mg pediatric tablets on Filipino children aged 6 to 11 for the relief of symptoms associated with perennial and intermittent allergic rhinitis.
- Trial name
- NCT00741897
- Testing
- Fexofenadine
- Where
- Philippines
- Volunteers
- 264 people
- Sponsor
- Sanofi
Rhinosinusitis
Allele-specific Expression of a Bitter Taste Receptor
This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste tissue of individuals heterozygous for the taste…
- Trial name
- NCT02766959
- Testing
- Observational study
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Breast Cancer, Chronic Myeloproliferative Disorders
Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Motexafin gadolinium may increase the effectiveness of doxorubicin by making tumor cells more sensitive to…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00036790
- Testing
- doxorubicin hydrochloride, motexafin gadolinium
- Where
- 2 sites in United States
- Sponsor
- University of Wisconsin, Madison
Otitis Externa
Topical Voltaren in Otitis Externa
Voltaren being a Non-steroidal anti-inflammatory drug (NSAID) drug may be used as a single drug therapy in otitis externa being both therapeutic and analgesic thus reducing consumption of oral analgesia.
- Trial name
- NCT00523120
- Testing
- diclofenac sodium, dexotc
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sieff Medical Center
Laryngeal Cancer, Hypopharyngeal Cancer
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
Investigate the role of MMPs in the CXCL12-induced invasion of laryngeal and hypopharyngeal squamous cell carcinoma
- Trial name
- NCT00302562
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Cochlear Hearing Loss
Comparison of Unilateral CI vs. Bimodal Stimulation in Prosodic Perception
An observational study to determine and assess perception of prosodic information in adults who use bimodal stimulation (cochlear implant plus hearing aid) when using both devices vs. cochlear implant alone.
- Trial name
- NCT06128161
- Testing
- Hearing Aid
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Nasopharyngeal Carcinoma
Surufatinib Combined With Toripalimab in Recurrent or Metastatic Nasopharyngeal Carcinoma
A prospective, single-arm,mutil-center study to assess the efficacy and safety of Surufatinib combined with Toripalimab in Recurrent or Metastatic Nasopharyngeal Carcinoma.
- Trial name
- NCT04955886
- Testing
- Surufatinib(HMPL-012)
- Where
- 2 sites in China
- Volunteers
- 14 people
- Sponsor
- Fujian Cancer Hospital
Seasonal Allergic Rhinitis
Efficacy Park Study Assessing Rhinix™ Nasal Filters for Hay Fever
This study will evaluate the effects of RHINIX™ nasal filters on seasonal allergic rhinitis (hay fever) in a park setting.
- Trial name
- NCT02108574
- Testing
- Rhinix Nasal Filter
- Where
- Denmark
- Volunteers
- 69 people
- Sponsor
- University of Aarhus
Laryngospasm
Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients
To describe laryngeal and respiratory reflex responses after controlled laryngeal stimulation in pediatric patients anesthetized with sevoflurane and to compare the evoked responses at two levels of anesthesia.
- Trial name
- NCT00665418
- Testing
- sevoflurane
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Oculopharyngeal Muscular Dystrophy
Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose
BB-OPMD-202 is a randomized, double-blind, placebo-controlled study of IV trehalose for treatment of OPMD. The study includes a 4-week screening period, a 24-week blinded treatment period during which patients will receive weekly…
- Trial name
- NCT04226924
- Testing
- Trehalose
- Where
- 3 sites in Canada
- Sponsor
- Bioblast Pharma Ltd.
Hearing Loss, Age-Related
Evaluation of a Digital Therapy of Auditory Training
The aim of the study is to evaluate the efficiency of the medical device AUDISSEE in improving the perception in noise ability of presbycusis patients with hearing-aids.
- Trial name
- AUDISSEE (NCT05848661)
- Testing
- AUDISSEE
- Volunteers
- 240 people
- Sponsor
- Humans Matter
Vertigo Benign Positional, Dizziness
The Effect of Chewing Gum on Dizziness in Patients Diagnosed With Posterior Canal Benign Paroxysmal Positional Vertigo in the Emergency Department
Dizziness is a common reason for emergency department visits. Posterior canal benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of peripheral vertigo.
- Trial name
- NCT07749573
- Testing
- Dimenhydrinate, Sugar-Free Mint-Flavored Chewing Gum
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Cervical Radiculopathy, Vertigo
Effect of Cervical Traction on Balance in Cervical Radiculopathy Patients
A cross-over randomized trial aiming to assess the immediate effect of cervical traction on balance disorders among patients with common cervical neuropathy.
- Trial name
- NCT04598113
- Testing
- Cervical Traction Device
- Where
- Tunisia
- Volunteers
- 20 people
- Sponsor
- University of Monastir
Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma
Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Aspirin Exacerbated Respiratory Disease (AERD) is a relatively homogeneous disease characterized by adult-onset severe asthma, development of non-cancerous growths in the nasal canal (i.e. nasal polyps) and aspirin allergy.
- Conditions
- Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma, Nasal Polyps
- Trial name
- AERD (NCT04261582)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
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