Clinical trials: Otitis
Otitis Media, Antimicrobial Stewardship
Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young Children
Randomized controlled trial involving 4 pediatric primary care practices in Massachusetts. Practices will be stratified by their OM diagnosis and treatment rate, with two practices randomly assigned to the intervention arm and…
- Trial name
- Wispr 2 (NCT07328555)
- Testing
- Device: Digital Otoscope
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston Children's Hospital
Chronic Otitis Media, Tympanic Membrane Perforation
A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty
This study was conducted to compare two methods of using temporalis fascia graft in tympanoplasty, namely wet temporalis fascia graft and dry temporalis fascia graft.
- Trial name
- NCT07595484
- Testing
- Wet Temporalis Fascia Graft Tympanoplasty, Dry Temporalis Fascia Graft Tympanoplasty
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Otitis Media Acute
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children
A pragmatic, mixed-method trial is to show the ability of OtoSight to change management of the pediatric patient presenting with ear pain in a way that improves patient outcomes and reduces costs.
- Trial name
- OTO-MATIC (NCT06285812)
- Testing
- OtoSight Middle Ear Scope
- Where
- 7 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- PhotoniCare, Inc.
Otitis Media With Effusion (OME), Otitis Media With Effusion in Children
Evaluation of Blowing Exercises Utilizing a Breathing Exercise Device in Otitis Media With Effusion
Otitis media with effusion (OME) is a common condition in which fluid collects behind the eardrum without signs of infection. It can cause hearing problems and discomfort.
- Conditions
- Otitis Media With Effusion (OME), Otitis Media With Effusion in Children, Breathing Exercise
- Trial name
- NCT06967506
- Testing
- Blowing exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Uşak University
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Sinusitis, Otitis
Complicated Infections in Otorhinolaryngology
This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are: What is the management of complicated sinonasal infections in Ljubljana, Slovenia, What…
- Conditions
- Sinusitis, Otitis, Laryngitis, Lymphadenitis
- Trial name
- ENT_infect (NCT06023550)
- Testing
- Treatment with surgery and/or conservative measures
- Where
- Slovenia
- Volunteers
- 2,550 people
- Sponsor
- University Medical Centre Ljubljana
Complement Deficiency, Antibody Deficiency
Systematic Search for Primary Immunodeficiency in Adults With Infections
Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections …
- Conditions
- Complement Deficiency, Antibody Deficiency, Chronic Sinus Infection, Meningitis, Bacterial
- Trial name
- SPIDAC (NCT02972281)
- Testing
- Immunological diagnosis tests
- Where
- 19 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Eczema/Atopic Dermatitis, Otitis Externa
Nigella Sativa Oil for Eczematous Otitis Externa
Eczematous otitis externa is a common inflammatory condition of the external auditory canal characterized by itching, discomfort, discharge, and pain.
- Trial name
- NCT07525505
- Testing
- Mometasone Furoate (MF), Nigella sativa oil
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Bezmialem Vakif University
Community Acquired Pneumonia (CAP), Sinusitis
Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care
The goal of this project is to reduce unnecessary antibiotic use for children with ARTIs (Acute Respiratory Tract Infections) by implementing "outpatient antibiotic stewardship" across the Children's Hospital of Philadelphia…
- Conditions
- Community Acquired Pneumonia (CAP), Sinusitis, Strep Pharyngitis, Acute Otitis Media (AOM)
- Trial name
- RAISIN (NCT07217002)
- Testing
- Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital of Philadelphia
Ear Infection, Otitis Media
In-Office Clinical Study of the Solo+ TTD
The objective of this study is to evaluate the safety and effectiveness of the Solo+ Tympanostomy Tube Device (Solo+ TTD) for the placement of tympanostomy tubes in paediatric patients undergoing a tympanostomy procedure.
- Trial name
- VENTY (NCT05741333)
- Testing
- Solo+ Tympanostomy Tube Device (Solo+ TTD)
- Where
- 7 sites in United States
- Volunteers
- 66 people
- Sponsor
- AventaMed DAC
Acute Otitis Media (AOM), Strep Pharyngitis
Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma
This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma…
- Conditions
- Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
- Trial name
- NCT07500532
- Testing
- Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medentum Innovations
RSV Infection, Children, Only
RSV Burden in Outpatient and Hospital Settings
Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)
- Conditions
- RSV Infection, Children, Only, Outpatient, Otitis
- Trial name
- Oursyn (NCT04743609)
- Testing
- nasopharyngeal samples
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Middle Ear Effusion, Otitis Media
Evaluating Laser Otoscope for Middle Ear Effusion Detection
The goal of this cross-sectional diagnostic accuracy investigational study is to learn about the usefulness of laser otoscopy in screening for middle ear fluid.
- Trial name
- NCT07454512
- Testing
- Laser otoscope examination
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- MSTATT LLC
Otitis Media in Children, Chronic Otitis Media With Effusion
Posterior vs. Anterior Tympanostomy Tube Placement
The goal of this randomized clinical trial is to compare the results of ear tube placement in two different parts of the ear drum. The ear drum can be divided into four parts (called quadrants).
- Conditions
- Otitis Media in Children, Chronic Otitis Media With Effusion, Recurrent Acute Otitis Media
- Trial name
- NCT06191562
- Testing
- Tympanostomy tube
- Where
- 2 sites in United States
- Volunteers
- 386 people
- Sponsor
- David Chi, MD
Middle Ear Infection
Spectroscopic Evaluation of Middle Ear Infection
Otitis media is more common in young children and it is estimated that 75% of all children experience at least one episode before the age of three.
- Trial name
- NCT04812093
- Testing
- Spectroscopic otoscope measurements
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Acute Respiratory Tract Infection, Otitis Media
Broad Implementation of Outpatient Stewardship
Reducing inappropriate antibiotic use is a key strategy to mitigate antibiotic resistance and adverse health effects associated with antibiotic exposure.
- Conditions
- Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
- Trial name
- BIOS (NCT05127161)
- Testing
- Broad Implementation of Outpatient Stewardship (BIOS) intervention
- Where
- 5 sites in United States
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pruritus, Dermatitis
Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations
In this observational study, insights regarding the tolerability and influence on the quality of life of the topical treatment with Ectoin Ear Spray compared to Normison ear spray shall be gained under real life conditions in…
- Conditions
- Pruritus, Dermatitis, Otitis Externa
- Trial name
- NCT02558738
- Testing
- ear spray
- Where
- 3 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Bitop AG
Acute Otitis Media (AOM)
V114 and Acute Otitis Media (V114-032/PNEU-ERA)
The primary objective is to evaluate V114 in the prevention of vaccine-type acute otitis media (VT-AOM) and the safety of V114 with respect to the proportion of participants with serious adverse events (SAEs) through completion…
- Trial name
- NCT04193215
- Testing
- V114, Pediatric vaccines
- Where
- 13 sites in Thailand
- Volunteers
- 7,119 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Otitis Media, Otitis Media With Effusion
Coherent Optical Detection of Middle Ear Disease
The purpose of this project is to see if optical coherence tomography (OCT), a new technology acting as an ultrasound for the ear, facilitates accurately diagnosing acute otitis media (AOM) and otitis media with effusion (OME) in…
- Conditions
- Otitis Media, Otitis Media With Effusion, Otitis Media Acute
- Trial name
- OCTII (NCT05353569)
- Testing
- OCT Device(s)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- Medical College of Wisconsin