Clinical trials: Otitis
Otitis Media
Prevention Recurrent Otitis Media in the Young Children
The purpose of this study is to find out if young children have more benefit of the combination of adenotomy and tympanostomy than plain tympanostomy in prevention of recurrent otitis media.
- Trial name
- NCT00162994
- Testing
- adenoidectomy and tymapanostomy
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Oulu University Hospital
Pain, Acute Otitis Media
Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media
To assess the clinical safety and efficacy of the Benzocaine relative to placebo in pain relief associated with acute otitis media.
- Trial name
- NCT02092454
- Testing
- Benzocaine
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Otic Therapy, LLC
Adenoid Hypertrophy, Middle Ear Effusion
It is Accepted That Adenoid Hypertrophy is Related to Otitis Media With Effusion Incidence. Better Understanding of the Correlation Between the Relative Size of AH and the Incidence of Persistent OME May Provide Evidence to Support a More Standardized Approach to the Diagnosis and Treatment of OME.
The aim of this study is to further investigate the correlation between Site and size of adenoid hypertrophy and middle ear effusion in order to provide evidence for designing a more standardized approach to the diagnosis and…
- Trial name
- NCT06674720
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Otitis Media in Children
Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction
Studies which describe the bacterial aetiology and antimicrobial susceptibility in AOM children in Latin America are scarce. Interestingly, when the MEF microbiology was analyzed among 1,108 children aged 2-92 months with OM…
- Trial name
- Microbiology (NCT02096848)
- Where
- Costa Rica
- Volunteers
- 387 people
- Sponsor
- Instituto de Atención Pediátrica
Acute Otitis Media
Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media
To determine whether tympanostomy tube placement (TTP) compared with nonsurgical management will meaningfully improve children's acute otitis media (AOM) experience over the succeeding 2 years.
- Trial name
- NCT02567825
- Testing
- Tympanostomy tube placement, Amoxicillin-Clavulanate and/or Ceftriaxone, Ofloxacin Otic
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Alejandro Hoberman
Chronic Otitis Media, Cholesteatoma
A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media
The purpose of the study is to study the clinicopathologic behaviour of the 3 dangerous types of chronic otitis media that are prone for complications.
- Trial name
- NCT00270660
- Testing
- biopsy, audiometry, ET function test, ear swab culture, DNE
- Where
- India
- Volunteers
- 192 people
- Sponsor
- Karnataka Institute of Medical Sciences
Nasal Obstruction, Nasopharyngeal Obstruction
Administration of Dexamethasone in PONV Prophylaxis in Children Undergoing Adenotomy
Adenotomy, together with tonsillectomy, belongs among the most frequently performed surgical procedures in paediatric patients. These surgical procedures are associated with the second highest incidence of post-operative nausea…
- Conditions
- Nasal Obstruction, Nasopharyngeal Obstruction, Snoring, Apnea, Obstructive
- Trial name
- NCT03398044
- Testing
- Dexamethasone
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava
Chronic Otitis Media
Retrospective Health Care Utilisation and Current Quality of Life in Adults With Chronic Otitis Media Who Had a Middle Ear Surgery
The objective of this multicentre study is to evaluate the standard of care of participants diagnosed with Chronic Otitis Media that have already gone through a first middle ear surgery but still have at least a moderate hearing…
- Trial name
- NCT04864912
- Testing
- Questionnaires and survey
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 69 people
- Sponsor
- Cochlear
Upper Respiratory Infection
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2
This study will test the hypothesis that constitutionally poorer Eustachian tube function predisposes to middle-ear pathology during a viral upper respiratory infection.
- Trial name
- NCT00694421
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Cuneyt M. Alper
Acute Otitis Media, Chronic Otitis Media
Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
This is a non-randomized, multicenter, prospective, clinical study intended to evaluate the effectiveness of a method for iontophoretic delivery of a buffered lidocaine/epinephrine solution for provision of tympanic membrane…
- Conditions
- Acute Otitis Media, Chronic Otitis Media, Recurrent Acute Otitis Media
- Trial name
- IONTO (NCT00941993)
- Testing
- Iontophoresis System (Acclarent)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Integra LifeSciences Corporation
Otitis Media
Pharmacokinetic Study of AL-60371 Otic Suspension in Pediatric Subjects Following Tympanostomy Tube Surgery
The purpose of this study is to describe the pharmacokinetics of AL-60371 otic suspension following two posologies of bilateral ototopical doses in pediatric subjects immediately after bilateral tympanostomy tube surgery.
- Trial name
- NCT01908764
- Testing
- AL-60371 otic suspension
- Sponsor
- Alcon Research
Otitis Media
The Effects of Ventilation Tubes - The SIUTIT Trial
The prevalence of otitis media among Greenlandic children is one of the highest in the world and twenty per cent of schoolchildren have impaired hearing in the frequencies for normal speech.
- Trial name
- SIUTIT (NCT02490332)
- Testing
- Ventilation tube treatment
- Where
- 6 sites in Greenland
- Volunteers
- 31 people
- Sponsor
- Zealand University Hospital
Otitis Media
Study Evaluating Microbiological Analysis of Spontaneous Draining Acute Otitis Media
Describe the patient population and bacterial microbiology of pediatric patients presenting with spontaneous draining acute otitis media
- Trial name
- NCT00768534
- Where
- Germany
- Volunteers
- 2,138 people
- Sponsor
- Pfizer
Acute Respiratory Tract Infection, Otitis Media
Broad Implementation of Outpatient Stewardship
Reducing inappropriate antibiotic use is a key strategy to mitigate antibiotic resistance and adverse health effects associated with antibiotic exposure.
- Conditions
- Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
- Trial name
- BIOS (NCT05127161)
- Testing
- Broad Implementation of Outpatient Stewardship (BIOS) intervention
- Where
- 5 sites in United States
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Acute Otitis Media, AOMT
Open-Label Study of OTO-201 for Treatment of AOMT
This is a 1-month, prospective, multicenter, open-label study in pediatric subjects with either unilateral or bilateral acute otitis media with tympanostomy tubes (AOMT).
- Trial name
- NCT02408796
- Testing
- OTO-201
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Otonomy, Inc.
Secretory Otitis Media, Acute Otitis Media
The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the Hearing
Secretory otitis media (SOM) or middle ear effusion is a common finding after acute otitis media (AOM). It is usually associated with 5-15 deci Bells hearing loss.
- Trial name
- NCT02549612
- Testing
- Moniri Otovent
- Volunteers
- 80 people
- Sponsor
- Vastra Gotaland Region
Acute Otitis Media, Allergic Rhinitis
A Trial of Point of Care Information in Ambulatory Pediatrics
Does presentation of clinical evidence for decision making at point-of-care improve prescribing patterns in ambulatory pediatrics?
- Conditions
- Acute Otitis Media, Allergic Rhinitis, Sinusitis, Constipation
- Trial name
- NCT00368823
- Testing
- Electronic point-of-care delivery system
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Washington
Acute Otitis Media (AOM)
Safety and Efficacy of wSp Vaccine in Young Children
The goal of this clinical trial is to evaluate whether the wSp vaccine can prevent nasopharyngeal colonization by pneumococcal bacteria in healthy young children who have received routine PCV15 or PCV20 vaccination.
- Trial name
- wSp005 (NCT07216430)
- Testing
- wSp vaccine, Saline (0.9% NaCl)
- Where
- 7 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Serum Life Science Europe GmbH
Chronic Suppurative Otitis Media
Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
Objective To observe the safety and tolerability of Pazufloxacin Mesylate Ear Drops of different concentrations in patients with simple chronic suppurative otitis media.
- Trial name
- NCT03675841
- Testing
- Pazufloxacin Mesilate ear drops
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Influenza
Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age
The main purpose of this study is to assess the efficacy of early oseltamivir treatment (started within 24 hours of the onset of influenza symptoms) in preventing the development of acute otitis media as a complication of…
- Trial name
- ETOPOM (NCT00593502)
- Testing
- oseltamivir
- Where
- Finland
- Volunteers
- 409 people
- Sponsor
- Hospital District of Southwestern Finland