Clinical trials: Osteoporosis Diagnosis, open to volunteers
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Type 2 Diabetes, Osteoporosis
Study on the Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes
This study will conduct a randomized controlled trial targeting patients with type 2 diabetes and a high risk of fractures. The aim is to evaluate the intervention effect of denosumab combined with edilossobulin on patients with…
- Conditions
- Type 2 Diabetes, Osteoporosis, Fractures
- Trial name
- NCT07063797
- Testing
- Denosumab treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients, Denosumab combined with eldecalcitol treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients
- Where
- 4 sites in China
- Volunteers
- 358 people
- Sponsor
- Peking Union Medical College Hospital
Osteoporosis
Multicenter Cohort Study on Osteoporosis
This is a multicenter cohort study on osteoporosis in nine cities of China which locate in the east, south, north, west, middle of China.
- Trial name
- NCT02958020
- Where
- 12 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Osteoporosis
People With Osteoporosis Can Walk-BEST to Reduce Fall and Fracture Risk
The aim of the Walk BEST study is to provide evidence that it is feasible to implement the technology assisted gait- focused walking program Walk-BEST™ in older adults with osteoporosis, and that this program is acceptable to…
- Trial name
- Walk-BEST (NCT07621679)
- Testing
- Device: Heel2Toe[TM] sensor, Technology-assisted therapeutic walking program
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bone Loss
Bone, Exercise, Alendronate, and Caloric Restriction
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.
- Trial name
- BEACON (NCT05764733)
- Testing
- Bisphosphonate, Resistance Training/Bone-Loading Exercise
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- Wake Forest University Health Sciences
Cystic Fibrosis, Hypoestrogenism
Estrogen Supplementation and Bone Health in Women With CF
The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF).
- Trial name
- STURDY (NCT05704036)
- Testing
- Transdermal estrogen, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Chronic Kidney Disease, Osteoporosis
Pharmacokinetics of Zoledronic Acid in Patients on Dialysis
Osteoporosis is a frequent complication of chronic kidney disease (CKD) on dialysis, with an estimated prevalence of approximately 40%. It is associated with increased fracture risk, reduced quality of life, and higher mortality.
- Conditions
- Chronic Kidney Disease, Osteoporosis, Dialysis
- Trial name
- ZADIAL (NCT07741136)
- Testing
- Zoledronic Acid Injection, 5.0 mg, single dose, Zoledronic Acid Injection, 2.5 mg, single dose
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Campinas, Brazil
Osteoporosis
Health ImprOvement Program of Bone in China
Fracture risk factors have long been identified as key factors in osteoporosis and fragility fractures. The WHO recommended Fracture risk assessmenttool (FRAX) applies clinical risk factors to assess the absolute risk of…
- Trial name
- NCT05906147
- Testing
- Regular follow-up
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Second Xiangya Hospital of Central South University
Osteoporosis
Preserving Geriatric Muscle With an Osteoporosis Medication
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
- Trial name
- NCT06118905
- Testing
- Denosumab 60 MG/ML, Zoledronic Acid 5Mg/Bag 100Ml Infusion
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Chrissy Kistler
Osteoporosis
Self-questionnaire in Osteoporosis
Osteoporosis is a multifactorial disease in which genetic predispositions play a key role in its development. A better understanding of family history and clinical manifestations among first- and second-degree relatives can help…
- Trial name
- NCT07067827
- Testing
- Self-administered questionnaire, Family tree
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- CHU de Quebec-Universite Laval
Osteoporosis
The Added Value of Bone Microstructure Assessment in the Management of Osteoporotic Bone
1. To assess the clinical utility of trabecular bone score (TBS) on fracture risk prediction including the new version (TBS V4) and future TBS versions at the spine and hip. 2.
- Trial name
- ADVANTAGE BONE (NCT06513442)
- Testing
- Trabecular bone score software
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Osteoporosis, Postmenopausal
Mechanisms of Anabolic Osteoporosis Therapy
The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.
- Trial name
- NCT05688969
- Testing
- early versus late biopsy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
NAFLD, Osteoporosis
Relation Between NAFLD and BM DENSITY
In general NAFLD is a common denominal for a broad spectrum of damage to the liver, which can be due to hepatocyte injury, inflammatory processes and fibrosis.
- Trial name
- NCT06038253
- Testing
- Fibroscan
- Volunteers
- 100 people
- Sponsor
- Assiut University
Osteoporosis
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
People with Alzheimer's disease are at an increased risk of bone fracture. Some studies have shown that those taking donepezil have a lower rate of bone fractures, but the reasons for this are unknown.
- Trial name
- NCT06041789
- Testing
- Donepezil, Memantine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Osteoporosis, Fracture
Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study
Aims: (1) to Establish the FLS services at the National Taiwan University Hospital Jinshan Branch. (2) To establish a anti-osteoporosis medication management service at Jinshan Branch.
- Trial name
- NCT02635022
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Osteoporosis, Obesity
Impact of Milk and Yogurt Supplementation on Bone Health, Body Composition, and Gut Microbiota in Canadian Young Adults
Milk and dairy products contain significant amounts of nutrients that contribute to optimal health - nutrients like calcium, vitamin D, and high-quality protein.
- Trial name
- NCT06265246
- Testing
- Habitual Diet + Milk, Habitual Diet + Yogurt
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Osteoporosis, Postmenopausal Osteoporosis
AGE Burden and Response to Antiresorptive Therapy in Osteoporosis
Osteoporosis is a common condition that increases the risk of bone fractures. Although antiresorptive treatments such as bisphosphonates and denosumab are effective in increasing bone mineral density, some patients continue to…
- Trial name
- NCT07329543
- Volunteers
- 240 people
- Sponsor
- Bursa City Hospital
Meniere Disease, Osteoporosis
Menier's Disease - Bone Density Study
Meniere's disease is a progressive and debilitating inner ear disease characterised by vertigo and hearing loss. Several studies have linked Menierws disease with lower bone density and lower vitamin D levels.
- Conditions
- Meniere Disease, Osteoporosis, Osteopenia, Vitamin D Deficiency
- Trial name
- NCT05322538
- Testing
- vitamin D plasma levels baseline, Dual-energy X-ray absorptiometry at baseline, cervical Vestibular evoked myogenic potentials at baseline
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Vertebra Compression Fracture
A Clinical Study to Collect Real-wordt Data on Safety and Clinical Performance of the VCFix Spinal System for Treatment of Vertebral Compression Fractures of (Suspected) Osteoporotic Origin.
This study is designed as a prospective, post-market, multi-center, single-arm study to collect real-world data of the VCFix Spinal System used in US clinical practice.
- Trial name
- EXPAND-US (NCT07920484)
- Testing
- VCFix Spinal System in stand-alone configuration
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Amber Implants B.V.
Osteoporotic Fractures, Osteoporosis
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
This is an international multicenter prospective observational study. Patients with radiologically confirmed, symptomatic, single- or multilevel contiguous TL (from T1 to L5) fractures as a result of primary osteoporosis will be…
- Trial name
- NCT07027306
- Testing
- Posterior stabilization (pedicle screws)
- Where
- 15 sites in United States, Argentina and 12 more
- Volunteers
- 648 people
- Sponsor
- AO Foundation, AO Spine