Clinical trials: Osteoporosis
Osteoporosis
Effect of Radius on Alpha Motor Neuron Excitability
This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density.
- Trial name
- ERAMNE (NCT00961870)
- Testing
- Forearm vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vakif Gureba Training and Research Hospital
Osteoarthritis
Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
Relacatib is being developed for the treatment of osteoporosis, osteoarthritis and possibly other bone disorders. Recent results suggest that relacatib interacts with the way our bodies metabolise drugs and so some drugs which…
- Trial name
- NCT00411190
- Testing
- Relacatib, Acetaminophen, Ibuprofen
- Where
- 2 sites in Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bone Loss, Jaw, Edentulous
Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration
The objective of this study is to test the bone formation capacity of a 3D printed scaffold with a plastic material called Polycaprolactone (PCL), compared to the use of synthetic bone grafts, for bone formation in the maxilla or…
- Conditions
- Bone Loss, Jaw, Edentulous, Edentulous Mouth, Jaw Fractures
- Trial name
- OSTEOPRINT (NCT06773923)
- Testing
- PCL Scaffold, PTFE + Bio-Oss®
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Osteoporosis, Humoral Hypercalcemia of Malignancy
One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, that can be given safely over one week.
- Conditions
- Osteoporosis, Humoral Hypercalcemia of Malignancy, Hyperparathyroidism
- Trial name
- NCT00580788
- Testing
- PTHrP (1-36)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporosis
PTH And Calcium Responses to Exercise (PACE) in Older Adults
Exercise that causes a decline in serum Calcium (Ca) as a result of dermal Ca loss stimulates bone resorption via an increase in Parathyroid Hormone (PTH).
- Trial name
- NCT02468817
- Testing
- Treadmill Exercise, Magnitude of Ca loss during Exercise at 26 degrees Celcius
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post-menopausal Osteoporosis
Bisphosphonate Action on the Appendicular Skeleton: Evidence for Differential Effects
A study to determine if the three licensed bisphosphonates (alendronate, ibandronate and risedronate):a) affect the peripheral skeleton differently, as assessed by quantitative ultrasound of bone (QUS), peripheral quantitative…
- Trial name
- NCT00666627
- Testing
- Ibandronate, Risedronate, Alendronate
- Where
- United Kingdom
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Diabetes Mellitus, Type 2, Osteoporosis
MR-based Characterization of Bone Marrow in Its Relevance to Skeletal Disease in Patients With Diabetes
For a long time, no direct connection was seen between the two common diseases diabetes mellitus and osteoporosis. However, as more and more younger people are affected by obesity, develop type 2 diabetes mellitus and suffer…
- Conditions
- Diabetes Mellitus, Type 2, Osteoporosis, Insulin Resistance
- Trial name
- NCT04950283
- Testing
- magnetic resonance examination, anthropometric and metabolic characterization
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Osteoporosis, Fractures
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups.
- Conditions
- Osteoporosis, Fractures, HIV Infection
- Trial name
- Probono1 (NCT01669954)
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- King's College London
Osteoporosis, Sarcopenia
The Effect of 6 Months of Local Vibration Training in Institutionalized Elderly
This randomized controlled intervention study in institutionalized elderly investigates the effect of 6 months of local vibration therapy applied on the thigh and hip on muscle strength, muscle mass, bone density, and…
- Trial name
- NCT01499186
- Testing
- Local Vibration
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoporosis, Postmenopausal
Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab Alone
This randomized open label clinical trial will evaluate the effect of continued denosumab alone over 18 months versus denosumab with added abaloparatide for 18 months.
- Trial name
- NCT04467983
- Testing
- Denosumab Injection, Abaloparatide
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Incretins, Osteoporosis
The Role of Incretins in Bone Remodeling in Humans
The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is…
- Conditions
- Incretins, Osteoporosis, Bone Remodeling, Healthy
- Trial name
- INCREMOS (NCT03966261)
- Testing
- blood sample
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Seizures, Convulsions
A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy
The purpose of this study is to investigate the influence of topiramate monotherapy on the bone and mineral metabolism markers, and bone density (the amount of mineral per square centimeter of bone ) in female participants with…
- Conditions
- Seizures, Convulsions, Epilepsy, Osteopenia
- Trial name
- NCT01030094
- Testing
- Topiramate, Carbamazepine, Valproic acid
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Janssen Korea, Ltd., Korea
Osteoporosis
Bone UltraSonic Scanner (BUSS) Clinical Optimization Study
The aim of this clinical study using Bone UltraSonic Scanner (BUSS) is to obtain clinical data which will help to optimize the BUSS examination procedure and its diagnostic algorithms for assessment of bone conditions.
- Trial name
- BUSS (NCT01056432)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Artann Laboratories
Preventive Screening, Prostate Cancer
Understanding and Discouraging Overuse of Potentially Harmful Screening Tests
Most prevention efforts focus on promoting services (e.g. vaccination, screening tests). While some of these services have clear net benefit, many instead have possible or clear net harm.
- Conditions
- Preventive Screening, Prostate Cancer, Osteoporosis, Colorectal Cancer
- Trial name
- NCT01694784
- Testing
- Quantitative Information Sheet, Qualitative Information Sheet, Narrative Information Sheet
- Where
- United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Osteoporosis
The Effect of a Short Educational Program on Young Women's Knowledge and Beliefs About Osteoporosis
The purpose of the study is to determine the effect of a short educational program on young women's knowledge and beliefs about osteoporosis.
- Trial name
- NCT00464412
- Testing
- Education
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Valdosta State University
Osteoporosis
Effect of Nutrition on Bone Metabolism as Assessed by 41Ca
The present study aims to develop a technique based on a single dose of a calcium isotope, which enables to determine the effect of a nutritional intervention on bone calcium metabolism.
- Trial name
- NCT01910142
- Testing
- vitamin K, calcium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- TNO
Osteoarthitis, Osteoporosis
Evaluation of Musculoskeletal Aging and Related Disorders Via Advanced Clinical Imaging
Study Overview This clinical research focuses on the development and validation of a multimodal artificial intelligence (AI) platform designed for the automated diagnosis and precise staging of two major musculoskeletal…
- Trial name
- NCT07474571
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Postmenopausal Osteoporoses
Clinical Study on Treatment of Postmenopausal Osteoporosis (Kidney Deficiency and Blood Stasis Syndrome) With Xulin Jiangu Granules
Osteoporosis is a common senile disease with a high incidence. The Chinese medicine differentiation treatment has small side effects and can be taken for a long time, which has certain advantages.
- Trial name
- CSOPOPWXJG (NCT03563235)
- Testing
- Xulin Jiangu granules, Calcitriol capsules
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
Osteoporosis, Sarcopenia
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs.
- Trial name
- NCT01057680
- Testing
- creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Bone Loss, Age-Related,
Effect of the High Impact Exercise on Bone Density in Prepuberal Girls
Osteoporosis has become a worldwide concern an a matter of public health as osteoporosis is a major contributing factor associated with insufficiency fracture of the spine, wrist and proximal femur, and as a result, can diminish…
- Trial name
- NCT02488122
- Testing
- High Impact Exercise, Low Impact Exercise
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota