Clinical trials: Osteonecrosis of Femoral Head
Non Traumatic Osteonecrosis of the Femoral Head (Hip)
Safety, Tolerability, and Preliminary Efficacy of Intra-Articular Injection of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Non-Traumatic Avascular Necrosis of the Femoral Head
This is a first-in-human, single-arm, open-label, dose-escalation, exploratory Phase I clinical trial designed to evaluate the safety, tolerability, and preliminary efficacy of local injection of mesenchymal stem cell-derived…
- Trial name
- NCT07787923
- Testing
- Exosome Intervention Group
- Volunteers
- 15 people
- Sponsor
- Beijing Jishuitan Hospital
Avascular Necrosis of the Femoral Head
Outcome After Avascular Necrosis of the Femoral Head in Young Patients
1. The course of AVN between Initial diagnosis and total hip replacement (THA) is analysed. The impact of early interventions versus conservative therapy in AVN before THA will be evaluated. 2.
- Trial name
- AVN (NCT03753282)
- Testing
- questionnaires for patient reported outcome, questionnaire for course of the disease
- Sponsor
- University Hospital, Basel, Switzerland
Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD)
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins.
- Conditions
- Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD), Benign Prostatic Hyperplasia (BPH), Cholecystitis
- Trial name
- NCT06772558
- Testing
- Desflurane Inhalation, mechanical ventilation (MV)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Legg-Calvé-Perthes Disease
Robotic Arm-assisted THA Vs. Conventional THA in Legg-Calvé-Perthes Disease
Flat hip, also called Legg-Calvé-Perthes disease, is clinically characterized by flattened femoral head, shortened femoral neck, and a center of rotation of the femoral head lower than the apex of the greater trochanter.
- Trial name
- NCT07122323
- Testing
- robotic arm-assisted total hip replacement, conventional total hip replacement
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Legg Calve Perthes Disease
Perthes Disease in Norway
Calvé-Legg-Perthes disease (CLP) is a hip disease in children whose femoral head becomes completely or partially necrotic. The disease is most common in five-six years of age.
- Trial name
- NCT03885960
- Where
- Norway
- Volunteers
- 216 people
- Sponsor
- Oslo University Hospital
Avascular Necrosis of Femur Head
Clinical Transformation of Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Avascular Necrosis of Femur Head
The commercial decalcified bone scaffold combined with the patient's autologous bone marrow mesenchymal stem cells was used for in vitro culture to form tissue-engineered bone, and the effect of this tissue-engineered bone in…
- Trial name
- NCT07101562
- Testing
- Tissue-engineered bone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Bone Marrow, Femoral Neck Fractures
Bone Marrow Injection in Fracture of Femoral Neck
Objectives: Primary objective : To investigate the predisposing factors for femoral neck fractures, including age, sex, and associated comorbidities.
- Trial name
- NCT07808294
- Testing
- Anatomical reduction and fixation with bone marrow injection, Anatomical reduction with Fixation
- Where
- Syria
- Volunteers
- 32 people
- Sponsor
- Yaser Alkanash
Femur Head Necrosis
Anesthesia Depth's Influence on Postoperative Delirium
The investigators,according to the eligibility criteria,plane to choose 80 elderly anticipates who will undergo selective hip replacement surgery.This participants will be randomly divided into 2 groups:light anesthesia depth…
- Trial name
- NCT02972762
- Testing
- Diprivan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiangya Hospital of Central South University
Osteonecrosis of the Femoral Head
RAB001（LLP2A-Ale） in Healthy Subjects
This trial is a single center, randomized, double-blind, placebo-controlled dose escalation study aimed at examining the safety, tolerability, and pharmacokinetics/pharmacodynamics of single and multiple injections of RAB001 in…
- Trial name
- LLP2A-Ale (NCT07545018)
- Testing
- RAB001 400 μg/kg group, RAB001 750 μg/kg group, Normal saline
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Total Hip Arthroplasty, Osteoarthritis, Hip
Corin MiniHip and Trinity Cup Clinical Surveillance Study
The aim of the study is to provide long term follow up data on the performance and safety of the Corin MiniHip and Trinity acetabular cup over a 10-year period.
- Conditions
- Total Hip Arthroplasty, Osteoarthritis, Hip, Traumatic Arthritis of Hip, Rheumatoid Arthritis of Hip
- Trial name
- NCT05186168
- Testing
- MiniHip Stem, Trinity Acetabular Cup System
- Volunteers
- 546 people
- Sponsor
- Corin
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
This study is intended to gather medium (5- to 7-years) and long-term (minimum 8- to 10-years) information regarding the performance and safety of the commercially available 36mm CERAMAX® Ceramic on Ceramic (COC) Total Hip System…
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- COC36mmPAS (NCT02096198)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- DePuy Orthopaedics
Avascular Necrosis of the Femoral Head
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with avascular necrosis of the femoral head.
- Trial name
- NCT01643655
- Testing
- Autologous Adipose Tissue derived MSCs Transplantation
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- R-Bio
Avascular Necrosis of the Femoral Head
Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUE
This study will evaluate the performance of biologically assisted core decompression with the PerFuse instrument and BioCUE in patients with bone lesions in the femoral head.
- Trial name
- REGP-44-00 (NCT02662881)
- Testing
- PerFuse Percutaneous Decompression System, BioCUE Platelet Concentration System
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Osteonecrosis of Femoral Head, Osteonecrosis; Aseptic, Idiopathic
Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip
The purpose of this study is to determine if prolonged administration of low-dose aspirin will prevent the progression of early-stage osteonecrosis of the femoral head and may even reduce the extent of involvement of the femoral…
- Trial name
- NCT03405974
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Femur Head Necrosis
Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis
The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
- Trial name
- NCT00244400
- Where
- Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Osaka City University
Osteoarthritis, Hip, Avascular Necrosis of Hip
Avenir Complete Post-Market Clinical Follow-Up Study
The main objectives of this study are to confirm the long-term safety, performance and clinical benefits the Avenir Complete femoral stem and its instrumentation when used in primary total, hemi, and revision hip arthroplasty.
- Conditions
- Osteoarthritis, Hip, Avascular Necrosis of Hip, Avascular Necrosis of the Femoral Head, Post-traumatic; Arthrosis
- Trial name
- NCT04731077
- Testing
- Avenir Complete Femoral Stem
- Where
- 9 sites in United States, Denmark and 4 more
- Volunteers
- 275 people
- Sponsor
- Zimmer Biomet
Femur Head Necrosis, Adverse Effect of Glucocorticoids and Synthetic Analogues
GWAS Identified Susceptibility Loci for Glucocorticoid-induced FHN in the Chinese Population
This is a observation clinical trial. We are collecting the patients with glucocorticoid. They were divided into the experiment group (with femur head necrosis) and control group (without femur head necrosis).Then, we will…
- Trial name
- NCT02365077
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Xijing Hospital
Osteoarthritis, Rheumatoid Arthritis
Project JAY THA Registration Study
This is a prospective, randomized, multicenter clinical study in Chinese subjects to compare the safety and efficacy of the Delta PLUS Femoral Head and SL-TWIN Stem with BIOLOX forte ball head and SL-PLUS Stem in total hip…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT02347384
- Testing
- Delta PLUS Femoral Head + SL-TWIN Stem, BIOLOX forte ball head + SL-PLUS Stem
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- Smith & Nephew Orthopaedics (Beijing) Limited
Osteonecrosis of the Femoral Head
Screening for Biomarkers of Osteonecrosis of the Femoral Head
Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and…
- Trial name
- NCT07545616
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Hip Dislocation, Femur Head Necrosis
Investigation of the Femoral Shortening Osteotomy in the Developmental Dislocation of the Hip (FSODDH)
Although older children and high dislocations may be more likely to require a femoral shortening osteotomy, the ultimate decision about whether or not to shorten a given femur should depend on the ease of femoral head reduction…
- Trial name
- FSODDH (NCT02633904)
- Testing
- Osteotomy, Non-osteotomy
- Volunteers
- 200 people
- Sponsor
- He Jin Peng