Clinical trials: Osteoarthritis (OA)
Osteoarthritis, Knee
Vitamin D to Slow Progression of Knee Osteoarthritis
Knee osteoarthritis (OA) is a common and disabling health problem in older adults and for which there is no cure. The purpose of this study is to determine the effects of vitamin D on knee OA symptoms and physical function in…
- Trial name
- NCT00306774
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Tufts Medical Center
Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty
GENicular Nerve Block in KNEE Arthroplasty
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty, Genicular Nerve Block
- Trial name
- GENKNEE (NCT07589127)
- Testing
- Preoperative genicular nerve block (GNB)
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Helse Møre og Romsdal HF
Chronic Pain, Central Sensitisation
Brain MRI for Knee OA
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years.
- Conditions
- Chronic Pain, Central Sensitisation, Knee Osteoarthritis
- Trial name
- NCT05986513
- Testing
- Cold Pressor Gel Test
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Toronto Rehabilitation Institute
Shoulder Osteoarthritis
PRP for Glenohumeral Osteoarthritis
The glenohumeral joint is the third most common large joint to be affected by OA. Conservative treatments include physical activity, corticosteroid injections, and medications.
- Trial name
- NCT05675527
- Testing
- Low-dose PRP, High-dose PRP, Saline
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis (OA) of the Knee, Neuromodulation
Percutaneous Neurostimulation in Knee Osteoarthritis
Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals.
- Trial name
- NCT07637682
- Testing
- nerve stimulation using a nerve stimulator to the genicular nerve, nerve stimulation using a nerve stimulator to the saphenous nerve
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Hand Osteoarthritis
Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Patients With Hand Osteoarthritis
Hand osteoarthritis (HOA) which affects the interphalangeal joints and the metacarpophalangeal of the thumb is a common disease, the prevalence of which being about 30 % of the population over than 70.
- Trial name
- TIDOA (NCT02477059)
- Testing
- tocilizumab, saline solution
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain, Osteoarthritis
Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis
The goal of this prospective study is to identify variables that can predict whether an interdisciplinary biopsychosocial intervention for patients with osteoarthritis will be successful.
- Conditions
- Chronic Pain, Osteoarthritis, Disability Physical
- Trial name
- CIR-predict (NCT05661760)
- Testing
- interdisciplinary multimodal pain treatment
- Where
- Netherlands
- Volunteers
- 2,309 people
- Sponsor
- Maastricht University
Pain Reduction, Function Improvement
Duloxetine for Pain in Older Adults With Knee Osteoarthritis (OA)
Osteoarthritis (OA), a common disabling condition, is the commonest type of arthritis worldwide.Pain is the leading symptom and is often chronic in na.
- Trial name
- NCT01425827
- Testing
- duloxetine HCL
- Where
- Egypt
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Osteoarthritis of the Knee
A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee
The primary purpose of the study is to evaluate the change from baseline after 4 weeks of topical administration of TV-45070 (4% and 8% ointment) compared with placebo for the relief of symptoms of primary OA affecting a single…
- Trial name
- NCT02068599
- Testing
- TV-45070
- Where
- 42 sites in United States
- Volunteers
- 389 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):
The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.
- Trial name
- MSC (NCT04326985)
- Testing
- Autologous Mesenchymal Stem Cells Treatment (MSCs), Hyaluronic acid (HA)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis
Effects of KT and Rigid Taping in Knee OA.
The purpose of the study is to compare the effects of kinesio taping and rigid taping in Knee Osteoarthritis to alleviate symptoms like pain, reduce range of motion and functional limitations.
- Trial name
- NCT05946434
- Testing
- Kinesio Tape Group, Rigid Tape Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Knee Arthritis Osteoarthritis
Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities
This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis.
- Trial name
- HILT-CM (KOA) (NCT07551245)
- Testing
- High-Intensity Laser Therapy (HILT), Conventional Physical Therapy Modalities
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Erbil Polytechnic University
Osteoarthritis, Knee, Meniscus Tear
Corticosteroid Meniscectomy Randomized Trial
Synovitis has an important role in the symptoms and progression of Osteoarthritis (OA). Inflamed synovium has been associated with both increased symptoms and increased progression in OA patients.
- Conditions
- Osteoarthritis, Knee, Meniscus Tear, Meniscus; Degeneration, Synovitis
- Trial name
- CoMeT (NCT04641351)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Knee Osteoarthritis (Knee OA)
A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
1. Study Objective To Explore the Efficacy and Evaluate the Safety of Vutiglabridin in Knee Osteoarthritis Patients 2. Background Glaceum Inc.
- Trial name
- NCT06845553
- Testing
- Vutiglabridin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Glaceum
Osteoarthritis, Knee
Reducing Knee Compression When Sleeping in Those With Knee OA
To determine whether a change in sleeping position so as to prevent the knee being 'pushed' into full extension when lying supine provides pain relief and/or symptom improvement in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04188054
- Testing
- Change in sleeping position, No change in sleeping position
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Bradford
Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)
The goal of this clinical trial is to see if people with knee osteoarthritis would be willing to comply and adhere to incorporating Recombinant Human Growth Hormone (rHGH), specifically Saizen Somatropin solution, into their…
- Trial name
- KORR (NCT07036003)
- Testing
- Somatropin (recombinant human growth hormone)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Dr. David Wasserstein
Pain
A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty
The purpose of this study is to evaluate the exposure of diclofenac in the plasma and in the knee joint following topical administration of DDEA gel 4 gram (g) applied twice daily for 7 days.
- Trial name
- NCT03497039
- Testing
- Diclofenac Diethylamine (DDEA) gel
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Knee OA, Osteoarthritis
Comparing Exercise Programs for Managing Knee Osteoarthritis
The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps…
- Conditions
- Knee OA, Osteoarthritis, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06711341
- Testing
- Whole-body Vibration (WBV) Training, Progressive Resistance Exercise (PRE), Home-Based Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Uludag University
Osteoarthritis (OA) of the Hip
Gait After THA: Direct Anterior vs Manual Posterior vs Robotic Posterior
The purpose of this study is to evaluate the gait biomechanics following THA on 3 groups of subjects undergoing DAA (manual) and PA (manual and robotic) surgical approaches.
- Trial name
- NCT07226973
- Testing
- Total hip arthroplasty via direct anterior approach (manual, non-robotic), Total hip arthroplasty via posterior approach (manual, non-robotic), Robotic-assisted total hip arthroplasty via posterior approach
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ochsner Health System