Clinical trials: Osteoarthritis
Osteoarthritis (OA) of the Knee
Effect of Steroid Injections in a Knee With Osteoarthritis
A steroid (triamcinolone) 40 mg will be compared to placebo in a randomized placebo-controlled clinical trial testing the effect of this steroid versus placebo given into the study knee joint that has osteoarthritis (OA).
- Trial name
- NCT01230424
- Testing
- Triamcinolone Acetonide
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Tufts Medical Center
Osteoarthritis, Hip, Femur Head Necrosis
Clinical Outcomes of Primary Cementless Total Hip Arthroplasty Using the Collarless Actis Stem
This study looks at how well a hip replacement using the collarless Actis stem works over five years. Total hip replacement is a common operation for people whose hip joint has been damaged by arthritis, by loss of blood supply…
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Femoral Neck Fractures, Arthritis Rheumatoid
- Trial name
- NCT07828080
- Testing
- Collarless Actis femoral stem
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Seoul National University Bundang Hospital
Rheumatoid Arthritis, Traumatic Arthritis
3DKnee™ System vs. the MJS Knee System
The purpose of this study is to compare the survivorship and efficacy of the Encore 3DKnee™ system with that of the Encore MJS™ Knee System in a group of 600 patients for whom data collection is already under way.
- Conditions
- Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
- Trial name
- NCT00764803
- Testing
- Encore 3DKnee™ system, Encore MJS™ Knee System
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Encore Medical, L.P.
Postoperative Pain, Postoperative Nausea and Vomiting
High-Dose Steroid for Hip Arthroplasty Patients Expected to Have Postoperative Pain
The purpose of the Study is to test a higher dose of steroids(Dexamethasone) given just prior to surgery in the setting of Fast-Track Hip-surgery with Arthroplasty in a group of expected High Pain Responders and the effect on…
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Hip Osteoarthritis, Perioperative/Postoperative Complications
- Trial name
- NCT03763760
- Testing
- Dexamethasone
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Arthritis Knee
Feasibility of Multi-modal Physical Therapy in Latino Older Adults With Moderate Knee Osteoarthritis
This is a small, pilot, pre/post evaluation study enrolling older Hispanic American adults with moderate knee arthritis to evaluate the feasibility of recruitment, retention and adherence after a multimodal 12-week, physical…
- Trial name
- NCT04219423
- Testing
- Multimodal physical therapy
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Degenerative Arthritis, Inflammatory Arthritis
Kinematics of Silastic Joint Replacements in the Hand
To assess in vivo the kinematics of single piece silastic joint replacements in the hand with magnetic resonance imaging
- Trial name
- NCT05441462
- Testing
- Silastic Joint Replacement
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wrightington, Wigan and Leigh NHS Foundation Trust
Knee Osteoarthritis
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis.
- Trial name
- NCT03491761
- Testing
- PRP Treatment, HA Treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Endeavor Health
Chronic Low Back Pain
Exposure to Potential Cytochrome P450 Pharmacokinetic Drug-Drug Interactions Among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions
Using a retrospective analysis of a large commercial claims database and a Medicare database, the investigators evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long-term opioid…
- Trial name
- NCT01177254
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- NEMA Research, Inc.
Knee Osteoarthritis, Knee Pain Chronic
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
The objective of this investigation is to evaluate the safety of the geniculate artery embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain caused by osteoarthritis with 24 months follow-up.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Swelling, Knee Arthritis
- Trial name
- NCT04472091
- Testing
- Genicular artery embolization (GAE)
- Where
- United States
- Sponsor
- Andrew Picel
Knee Osteoarthritis
Instrumental Versus Standard Rehabilitation for Knee Osteoarthritis
A randomized clinical trial to evaluate the effectiveness of an instrumental rehabilitation protocol compared with standard protocol In patients with knee osteoarthritis.
- Trial name
- NCT06178380
- Testing
- rehabilitation
- Where
- 2 sites in Morocco
- Volunteers
- 60 people
- Sponsor
- Mohammed V Souissi University
Degenerative Joint Disease, Osteoarthritis
Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)
You are being asked to take part in this research study because you are scheduled to have total hip replacement (arthroplasty) surgery.
- Trial name
- NCT01391182
- Testing
- EACA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Blood Loss, Pain
Role of Autologous Platelet Rich Plasma in Total Knee Arthroplasty
This study was designed to evaluate the efficacy of leucocyte free autologous platelet rich plasma on blood loss, pain, wound healing and functional outcome after total knee arthroplasty.
- Trial name
- PRPTKA2012 (NCT01563380)
- Testing
- Platelet rich plasma
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Osteoarthritis, Hip
Metal-metal Articulations Versus Standard 28 mm Cementless Total Hip Arthroplasty
Younger hip patients often need revision of their hip replacement due to wear and loosening. Newer concepts (resurfacing and large head total hip replacement) with articulation surfaces in metal may reduce the wear, increase the…
- Trial name
- NCT01113762
- Testing
- articular surface replacement ASR, DePuy, ReCap/Magnum modular head, Biomet, Bimetric stem, mallory/head cup, 28 mm ceramic head, Biomet
- Where
- 2 sites in Denmark
- Volunteers
- 71 people
- Sponsor
- University of Southern Denmark
Inflammatory Tissue Disorder, Osteoarthritis
Mobile - Bearing Knee Study
To evaluate the safety and efficacy of the Encore Mobile-Bearing Knee.
- Conditions
- Inflammatory Tissue Disorder, Osteoarthritis, Avascular Necrosis, Post-traumatic Arthritis
- Trial name
- NCT00765362
- Testing
- Encore Mobile-Bearing Knee
- Where
- 8 sites in United States
- Volunteers
- 419 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis
Resiliency in Total Joint Arthroplasty
The investigators primary objective is to determine how does participation in StreaMD affect patient reported outcomes after Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA)?
- Trial name
- NCT04357262
- Testing
- StreaMD
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Utah
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
Osteoarthritis, Thumb Arthritis
Predictive Model for 1-Year Pain and Function Outcomes After Thumb Joint Surgery in Osteoarthritic Patients
This study aims to develop a predictive model to help doctors better understand expected outcomes one year after thumb joint surgery for osteoarthritis.
- Conditions
- Osteoarthritis, Thumb Arthritis, Arthroplasty of the MCP Joint
- Trial name
- NCT06740851
- Testing
- Touch® Trapeziometacarpal Joint Arthroplasty
- Where
- Switzerland
- Volunteers
- 330 people
- Sponsor
- Michael Oyewale
Knee Osteoarthritis, Pain
The Effects of Collateral Meridian Therapy for Knee Osteoarthritis Pain Management
Collateral meridian therapy (CMT) is a recently developed technique according to traditional Chinese medicine (TCM) experiences, differing from traditional Chinese acupuncture in numerous manners.
- Trial name
- NCT01532531
- Testing
- "GEMORE" Multi-Function Electrotherapy Stimulator
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- Taichung Armed Forces General Hospital
Osteoarthritis, Peripheral
Innovative Device for Pain Management by Millimeter Band Radiation : Electronic-Pain Killer.
In this study, in addition of conventional treatment, the efficacy of the medical device, Remedee One, in medical care of patients with peripheral osteoarthritis pain is evaluated.
- Conditions
- Osteoarthritis, Peripheral, Pain
- Trial name
- Epikarthrose (NCT04590079)
- Testing
- Conventional pain treatment with daily sessions with innovative medical device, Remedee One, for pain management by Millimeter Band Radiation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Knee Osteoarthritis
Prospective Evaluation of Biomarkers Variability in Knee Prosthetic Surgery
Bone quality is an important factor influencing the outcome of total knee replacement (TKR) surgery. Therefore, assessing bone quality preoperatively could help the surgeon in the choice of the most appropriate prosthetic…
- Trial name
- NCT01971931
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
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