Clinical trials: Osseointegration
Atrophic Maxilla, Partial Edentulism
Prospective Study of Bone Augmentation With Lateral Sinus Lift and Osseointegration of Dental Implants
By using a split-mouth model in the maxilla, lateral sinus lift procedures will be performed using xenograft on one side vs autologous bone augmentation and PRF membranes on the other side.
- Trial name
- NCT07014085
- Testing
- "Histomorphometric Evaluation of Bone Augmentation Using Xenografts Versus Autologous Bone Grafts in Dental Implant Patients: A Comparative Clinical Study
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maria H. Pham
Diabetes Mellitus
Alveolar Bone Changes in Diabetes (ABCD) Study
Type 2 Diabetes Mellitus (DM) is a very prevalent metabolic disorder in the adult population affecting roughly 17.7 million people in the US alone.
- Trial name
- ABCD (NCT02395315)
- Testing
- Well-controlled diabetic (WC), Poorly controlled diabetics (PC)
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Minnesota
Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase
Clinical Assessment of UV Photofunctionalization on Stability and Osseointegration of Early Loaded Implants
The goal of this clinical trial is to learn if UV light treatment (photo functionalization) works to help dental implants heal faster and become stable enough for early use in adults missing teeth in the lower back jaw.
- Conditions
- Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase, Determining the Feasibility and Success Rate of an Accelerated "Early Loading" Protocol, Assessing the Survival Rate of the Implants, Along With the Peri-implant Soft Tissue Response and Marginal Bone Preservation
- Trial name
- UV (NCT07868744)
- Testing
- UV-photofunctionalized titanium dental implants
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Amputation, Osseointegration
Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients
This will be a prospective observational trial enrolling 20 patients with osseointegrated prostheses. Participants will be recruited from the orthopaedic outpatient clinic at Walter Reed National Military Medical Center in…
- Trial name
- NCT06777511
- Testing
- 5-aminolevulinic acid (5-ALA), Photodynamic therapy (PDT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Amputation, Transfemoral Amputation
Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training
This randomized controlled trial (n=25 enrolled, n=15 expected to complete) will 1) determine the feasibility of a 40-week limb-load biofeedback training intervention, 2) determine if there is an intervention signal of efficacy…
- Conditions
- Amputation, Transfemoral Amputation, Osseointegration
- Trial name
- TOPLOAD (NCT05695911)
- Testing
- Limb Load Biofeedback Training Intervention, Attention Control
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
Post-osseointegration Biological Failure of Dental Implant, Alveolar Bone Loss
The Influence of Mucosal Tissue Thickness on Soft and Hard Tissue Changes Around Implants
Crestal bone and soft tissue stability around implants is an important issue in implant dentistry. Initial vertical mucosal tissue thickness was shown to be one of the factors having impact on bone stability.
- Trial name
- NCT02580721
- Testing
- Dentsply Astra Tech Implant System EV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Tooth Loss
Evaluation of Enamel Matrix Derivative in Immediate Dental Implants in the Mandibular Molar Region
This randomized clinical trial will evaluate the effect of using an enamel matrix derivative during immediate dental implant placement in the mandibular molar region.
- Trial name
- NCT07727655
- Testing
- Enamel Matrix Derivative (Emdogain), Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Jaw, Edentulous, Partially, Bone Resorption
Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw
The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla…
- Conditions
- Jaw, Edentulous, Partially, Bone Resorption, Dental Implant Failure
- Trial name
- UV-MEL-IMPLANT (NCT07853976)
- Testing
- UV-Photofunctionalized Dental Implant, Conventional Dental Implant
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Implant
Low-Level Diode Laser Therapy on the Acceleration of Osseointegration Around Delayed Dental Implant
Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant…
- Trial name
- NCT07536451
- Testing
- Dental implant + LLDL, Dental implant
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Hams Hamed Abdelrahman
Immediate Dental Implant Placement, Immediate Dental Implant Loading
Influence of the Primary Stability and Temporary Prosthetics
The goal of this clinical trial is to to determine how different primary implant stability and loading management affect implant osseointegration and further function after one year.
- Conditions
- Immediate Dental Implant Placement, Immediate Dental Implant Loading, Marginal Bone Levels
- Trial name
- NCT07585539
- Testing
- Implant placement, Healing abutment, Temporary crown
- Volunteers
- 90 people
- Sponsor
- Tomas Linkevicius
Peri-Implantation Loss, Periodontal Bone Loss
The Rehabilitation of Atrophic Jaws Using Short Implants With Different Surface Characteristics
The aim of the research is to evaluate the clinical outcome of short dental implants, characterized by a new macro-structural design and inserted in the upper or lower jaw in patients with reduced bone volume.
- Conditions
- Peri-Implantation Loss, Periodontal Bone Loss, Periimplantitis, Gingival Inflammation
- Trial name
- NCT05766878
- Testing
- implants placement
- Where
- 3 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Crestal Bone Resorption, Implant Primary Stability
Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol
Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol
- Conditions
- Crestal Bone Resorption, Implant Primary Stability, Implant Osseointegration
- Trial name
- RCT (NCT03250949)
- Testing
- implant site over drilling protocol
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Azhar ALI ELSAYED SELEEM
Alveolar Bone Loss in Mandible, Edentulous Alveolar Ridge In Mandible
Clinical Study of INFUSE® Bone Graft Compared to Autogenous Bone Graft for Vertical Ridge Augmentation
The purpose of this study is to evaluate the INFUSE® Bone Graft as an alternative to autograft for bone formation in the back of the mandible (lower jaw) prior to placing dental implants.
- Trial name
- NCT01308996
- Testing
- INFUSE® Bone Graft, Autogenous bone graft from tibia or iliac crest
- Sponsor
- Medtronic Spinal and Biologics
Alveolar Bone Atrophy
RCT With 3 Different Biomaterials for Maxillary Sinus Lift
Background: Lateral maxillary sinus augmentation (MSA) is a predictable bone regeneration technique in case of atrophy of the posterior-upper maxilla.
- Trial name
- NCT04506827
- Testing
- Maxillary Sinus Augmentation, Maxillary Sinus Graft with ABBM, Maxillary Sinus Graft with TCP
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Pisa
Implant Therapy
Clinical and Radiographic Evaluation of Local Melatonin Application on Osseointegration of Immediate Mandibular Implants
Clinical and Radiographic Evaluation of Local Application of Melatonin on Osseointegration of Immediate Dental Implants for Mandibular Single Rooted Teeth: A Randomized Controlled Study
- Trial name
- NCT07374523
- Testing
- Melatonin gel, Control
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Suez Canal University
Amputation, Transtibial Amputation - Unilateral
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic…
- Conditions
- Amputation, Transtibial Amputation - Unilateral, Bone Anchored Devices, Osseointegration
- Trial name
- TBAL (NCT07263945)
- Testing
- As-prescribed prosthetic foot stiffness, A prosthetic foot that is two prosthetic foot stiffness categories stiffer than the stiffness of the as-prescribed prosthetic foot, A prosthetic foot that is two prosthetic foot stiffness categories softer than the stiffness of the as-prescribed prosthetic foot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Vitamin D Deficiency, Osseointegration Failure of Dental Implant
Vitamin-D Insufficiency and Implants
Vitamin D is important for bone health, immune function, and inflammation, along with dental implant success. The study aimed to assess bone markers and cytokine levels in patients with and without vitamin D insufficiency to…
- Conditions
- Vitamin D Deficiency, Osseointegration Failure of Dental Implant, Peri-Implantitis
- Trial name
- NCT06452251
- Testing
- OPG, OC, RANKL, IL-10, IL-1β, Ca, TNF-α and Caspase-1 ELISA, Resonance Frequency Analysis, Periodontal clinical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Vesile Elif Toy
Edentulous Alveolar Ridge
Effect on Allogenic Mesenchymal Stem Cells on Osseointegration of Dental Implants
As Regenerative Medicine is the next level in medicinal sciences, the use of mesenchymal cells have become prevalent, Similarly now stem cells are being used in dental research as well in various clinical applications.This study…
- Trial name
- MSC&IMPLANTS (NCT02731586)
- Testing
- Allogenic Mesenchymal stem cells
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sri Sai College of Dental Surgery and Research Centre
Implant Site Reaction
Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration
The number of patients treated in Implantology at Nantes University Hospital is 400 per year. This pilot study aims to demonstrate the efficacy of a 6-month oral cholecalciferol supplementation on osseointegration in patients…
- Trial name
- OSIVID (NCT06776640)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital