Clinical trials: Orthodontic
Class II Canine, Intermaxillary Strength
Study Evaluating the Laser Diode Effect on the Kinetics of Orthodontic Tooth Movement (Protocol CINELASER)
It is a single-center, prospective clinical study of a medical device, controlled, randomized, non-stratified, double-blind (neither the patient nor the parents know which area is irradiated / practitioner who performs the…
- Conditions
- Class II Canine, Intermaxillary Strength, Elastics II, Multi Fasteners Orthodontic Treatment
- Trial name
- CINELASER (NCT02181439)
- Testing
- (LLLT Low Level Laser Therapy) SiroLaser advance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Nantes University Hospital
Orthodontic
The Influence of Anatomical Characteristics and Orthodontic Force on Pulpal Oxygen Saturation: A Clinical Study Using Cone-Beam Computed Tomography (CBCT)
The primary objective of this clinical protocol is to evaluate and compare the physiological responses of dental pulp to two different magnitudes of orthodontic force during active orthodontic treatment.
- Trial name
- NCT07630818
- Testing
- 150g Orthodontic Force Application, 50g Orthodontic Force Application
- Where
- Vietnam
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Dental Plaque, Orthodontic Patients
Comparison of the Effectiveness of Miswak and Manual Toothbrush in Removing Dental Plaque in Fixed Orthodontic Patients
This study compares the immediate plaque removal efficacy of the natural Miswak versus a traditional manual toothbrush using the Modified Bass technique among orthodontic patients.
- Trial name
- NCT07619014
- Testing
- Natural Miswak (Al-Kureysh, Pakistan), Manual Toothbrush (Colgate Zig Zag, China)
- Where
- Syria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Hawash Private University
Orthodontic Treatment, Saliva
Salivary Flow, pH, and Buffering Capacity in Fixed and Clear Aligner Orthodontic Treatment
Study Design: A randomized controlled trial with two parallel arms and an allocation ratio of 1:1. Setting: The study will be conducted in the orthodontic department of Riyadh Elm University hospitals in Riyadh City, Saudi…
- Trial name
- NCT07397871
- Testing
- Fixed orthodontic appliances, Clear Aligner Treatment
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Riyadh Elm University
Malocclusion, Canine Retraction
Maxillary Canine Retraction Using Stainless Steel and Titanium-molybdenum Alloy Wires in TAD-supported Segmental Mechanics
The goal of this randomized clinical study is to compare the effectiveness of stainless steel (SS) and titanium-molybdenum alloy (TMA) wires for maxillary canine retraction using TAD-supported segmental mechanics.
- Conditions
- Malocclusion, Canine Retraction, Orthodontics, Tooth Movement Techniques
- Trial name
- NCT07645417
- Testing
- A titanium-molybdenum alloy reverse-closing loop, A stainless steel reverse closing loop
- Where
- Bangladesh
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tanzila Rafique
Pain Perception, Root Resorption
The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial
Brief Summary of the Study This study investigates the effects of locally administered vitamins C and E on orthodontic tooth movement during the initial stage of treatment.
- Conditions
- Pain Perception, Root Resorption, Rate of Orthodontic Tooth Movement, Biomarkers
- Trial name
- NCT06847880
- Testing
- 1: Vitamin C Supplementation, Vitamin E Supplementation, Saline Solution (Control)
- Where
- 3 sites in Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Orthodontic Tooth Movement
Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners
This study compares the effectiveness of two adjunct therapies- photobiomodulation (low-level laser therapy) (PBM) and localized platelet-rich plasma (PRP) injections in accelerating orthodontic tooth movement.
- Trial name
- NCT07795073
- Testing
- Platelet Rich Plasma (PRP) injection, photobiomodulation (PBM) Therapy, clear aligner(12-hour wear protocol)
- Where
- Yemen
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sana'a University
Acute Stress Response During Orthodontic Mini-screw Placement
Effects of Music Therapy on Stress During Orthodontic Mini-screw Placement
This randomized clinical trial evaluated acute stress responses during orthodontic mini-screw placement and whether listening to music during the procedure influenced these responses.
- Trial name
- NCT07793669
- Testing
- Music Listening Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Himmet YILDIRIM
Dental Crowding, Dental Occlusion, Traumatic
Exploration of the Utility of Dental-dedicated MRI for Dentistry
This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images.
- Conditions
- Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment
- Trial name
- NCT06948162
- Testing
- dental-dedicated MRI (ddMRI)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Gingivitis, Orthodontic Treatment
Effect of Individually Trained Oral Prophylaxis (iTOP) on Gingival Health in Orthodontic Patients
This randomized controlled clinical trial aims to evaluate the effectiveness of individualized oral hygiene education using the Individually Trained Oral Prophylaxis (iTOP) method compared with conventional oral hygiene…
- Trial name
- NCT07468773
- Testing
- Individually Trained Oral Prophylaxis (iTOP) Oral Hygiene Training, Conventional Oral Hygiene Instruction
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Orthodontic Pain (D013850), Anxiety
Effect of Alpha Binaural Beat Music on Pain After Orthodontic Separator Placement
Orthodontic pain is one of the most frequently reported adverse experiences during fixed appliance therapy and is particularly pronounced during the initial stages of treatment.
- Trial name
- ABB-PainRCT (NCT07771920)
- Testing
- Alpha-Frequency Binaural Beat Music
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Aga Khan University
Periodontal Disease; Gingivitis; Dental Plaque; Malocclusion (Post-orthodontic Treatment)
Digital vs Conventional VFR in Post-Orthodontic Retention
This study is comparing two ways of making a retainer, the clear, removable kind worn after braces to see whether the way it's made affects gum health.
- Trial name
- NCT07760935
- Testing
- Digital Vacuum-Formed Retainer, Conventional Vacuum-Formed Retainer
- Volunteers
- 52 people
- Sponsor
- Ziauddin University
Chewing Function, Low Level Laser Therapy
Effect of Low-Level Laser Therapy on Spontaneous and Chewing Pain Associated With Orthodontic Elastomeric Separator Placement
The objective of this study is to determine the efficacy of LLLT at a wavelength of 635 nm on: Spontaneous pain between laser and placebo group with the placement of orthodontic elastomeric separators.
- Conditions
- Chewing Function, Low Level Laser Therapy, Pain, Visual Analog Scale
- Trial name
- NCT07651774
- Testing
- Low Level Laser Therapy, Control
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Foundation University Islamabad
Maxillary Expansion, Forensic Dentistry
Evaluation of Palatal Rugae-Based Identification After Maxillary Expansion Using Local Morphological Patch Analysis
This study investigates the reliability of palatal rugae-based identification following maxillary expansion procedures, including Miniscrew-Assisted Rapid Palatal Expansion (MARPE) and Surgically Assisted Rapid Maxillary…
- Conditions
- Maxillary Expansion, Forensic Dentistry, Intraoral Scanner, Orthodontic Appliance
- Trial name
- NCT07667933
- Testing
- SARME, MARPE, Untreated Control
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Semmelweis University
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Orthodontic Pain
Comparison Between the Effectiveness of Low-Grade Laser Therapy vs. Conventional Analgesics for Pain Reduction During Orthodontic Treatment in Malay Female Population
All patients will be treated using the fixed appliance on the upper and lower arches. 0.014" Niti(Nickel-Titanium) archwire is used to ensure all patients will receive the same force. All participants will receive a pain diary.
- Trial name
- LLTvsANALG (NCT07747350)
- Testing
- Low-Level Laser Therapy (LLLT), Conventional Analgesic (Paracetamol)
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- ROA RAAD FADHEL
Malocclusion, Angle Class II, Overbite (Excessive) Horizontal
Long-term Stability of Treatment With the Twin Block Appliance
The objective of this observational study is to investigate the long-term stability of treatment with the Twin block appliance in a patient group previously treated with a Twin block appliance.
- Conditions
- Malocclusion, Angle Class II, Overbite (Excessive) Horizontal, Overbite (Excessive) Deep, Treatment Outcome
- Trial name
- NCT07752498
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Region Jönköping County
Orthodontic Relapse, Malocclusion
3D-Printed vs Conventional Fixed Retainers After Orthodontic Treatment
This randomized clinical trial aims to compare the clinical performance of two types of three-dimensionally printed fixed retainers (Cobalt-Chromium and Titanium Grade 5) with the conventional multistranded stainless steel fixed…
- Trial name
- NCT07730476
- Testing
- Conventional Multistranded Stainless Steel Fixed Retainer, 3D-Printed Cobalt-Chromium Fixed Retainer, 3D-Printed Titanium Fixed Retainer
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Minia University
Orthodontic Brackets
Digital Bonding vs. Direct Bonding Study
This is a prospective, 2-armed, randomized, multi-site clinical study to demonstrate that digital bonding is a more efficient treatment method than direct placement of brackets.
- Trial name
- NCT06266130
- Testing
- Treatment Group Digital Bonding Tray, Control Group Direct Bonding
- Where
- 5 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Solventum Orthodontics Corporation
Fixed Orthodontic Retainer, Orthodontic Appliances, Removable
Bacterial Diversity Study Using 16S rRNA Sequencing of Periodontal Samples From Patients With Orthodontic Retainers
After completion of orthodontic treatment, a retention phase is required to prevent relapse of tooth malposition. Fixed retention in the mandibular anterior region is commonly used.
- Conditions
- Fixed Orthodontic Retainer, Orthodontic Appliances, Removable, Orthodontic Appliance Complication, Gingivitis
- Trial name
- Ortho-Perio (NCT07718061)
- Testing
- Fixed Orthodontic Retainer, Removable Essix-Type Orthodontic Retainer
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad de Murcia