Clinical trials: Oral Pain
Post-Op Complication, Endodontic Inflammation
Postoperative Pain After Using NiTi Instruments
The aim of this randomized clinical trial was to compare the incidence, intensity and duration of postoperative pain following the removal of root canal obturation materials canals using rotary (ProTaper Universal or Hyflex EDM)…
- Conditions
- Post-Op Complication, Endodontic Inflammation, Endodontically Treated Teeth, Apical Periodontitis
- Trial name
- NCT04700995
- Testing
- NiTi instruments
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Trakya University
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cryotherapy Effect
Intraoral Cryotherapy in Root Canal Retreatment
The aim of this study was to evaluate the effect of intraoral cryotherapy application on postoperative pain in single and multiple visit retreatment of teeth with symptomatic or asymptomatic apical periodontitis.
- Trial name
- NCT05091554
- Testing
- intraoral ice pack application
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Pain, Postoperative, Quality of Life
To Evaluate Postoperative Pain and Quality of Life After Taking a Deephethelized Gingival Graft and Covering it With Different Treatments
Objective: To evaluate postoperative pain and quality of life in relation to oral health after obtaining a palatal de-epithelialized gingival graft and subsequent coverage of the surgical wound with an adhesive film of cellulose…
- Conditions
- Pain, Postoperative, Quality of Life, Palate; Wound
- Trial name
- NCT06408792
- Testing
- Deepithelized graft and protection technique
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
TMD, TMD/Orofacial Pain
Treatment Outcomes in Patients With Muscular Temporo-mandibular Joint Disorders
The aim of the present study was to assess the treatment outcomes in patients affected by M-TMDs in terms of pain scores assessed with pressure pain threshold (PPT).
- Trial name
- NCT06339736
- Testing
- Questionnaires administered to all study participants
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Endodontically Treated Teeth, Postoperative Pain
Different Endodontic Treatment Techniques in Postoperative Symptoms, Apical Repair, Longevity of Rehabilitations, and Oral Health-related Quality of Life
Objective: The objective of this study will be to evaluate the effectiveness of different endodontic treatment techniques in postoperative symptoms, apical repair, longevity of rehabilitations, and oral health-related quality of…
- Conditions
- Endodontically Treated Teeth, Postoperative Pain, Edema, Photochemotherapy
- Trial name
- NCT03704857
- Testing
- Foraminal Enlargement / Irrigating solutions / Filling materials, Photobiomodulation, Passive ultrasonic irrigation
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Trigeminal Neuralgia (TN), Other Neuropathic Pain
New Formulation and Food Effect Study of BIIB074
The primary objectives of the study are to assess the relative bioavailability of the BIIB074 direct compression formulation (DCF) to the BIIB074 roller compaction formulation (RCF) and to determine the effect of a high-fat meal…
- Trial name
- NCT02951221
- Testing
- BIIB074 Treatment A, BIIB074 Treatment B, BIIB074 Treatment C
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Biogen
Postoperative Sensitivity, Rebound Pain
Menstrual Cycle Effects on Postoperative Sensitivity and Rebound Pain in Composite Restorations
This study aims to evaluate how different phases of the menstrual cycle affect pain after dental treatments. Specifically, it investigates two types of pain: Postoperative sensitivity (pain felt after the filling procedure), and…
- Conditions
- Postoperative Sensitivity, Rebound Pain, Menstrual Cycle, Composite Restorations
- Trial name
- NCT06886243
- Testing
- Direct Posterior Composite Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Firat University
Pulp Necrosis
Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
This study aims to compare regenerative endodontics for necrotic young permanent anterior teeth using oral photo-activated disinfection versus triple antibiotic paste in terms of: 1.
- Trial name
- NCT03763110
- Testing
- Photo Activated Disinfection, antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis, Pain
Effects Of Low Level Laser Therapy On Tooth Movement,Treatment Related Complications Of Gingivitis,Periodontitis And Pain In Fixed Orthodontic Patients
INTRODUCTION Orthodontic treatment objectives are achieved through the movement of teeth with the application of an external physical force.
- Conditions
- Gingivitis, Pain, Periodontitis, Tooth Migration
- Trial name
- NCT04230096
- Testing
- low level laser therapy
- Where
- Pakistan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Dental Pain
Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction
The purpose of this trial is to determine if XPF-001 is effective for the treatment of pain following third-molar/wisdom tooth extraction.
- Trial name
- NCT00954356
- Testing
- XPF-001
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Myofacial Pain Syndrome
Intramuscular Electrical Stimulation on Upper Trapezius With Trigger Points
The prevalence of myofascial pain ranges from 30 to 93% and can result in sensorimotor and autonomic deficits. In routine neuromuscular electrical stimulation, conventional electrode placement (CEP) and inverse electrode…
- Trial name
- NCT06604962
- Testing
- IMES using IEP, IMES using CEP
- Where
- United Arab Emirates
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Bruxism, Face Pain
Effect of Cervical Manipulation on Mouth Opening
Objectives: To compare the effects of cervical manipulation on the ranges of motion of mouth opening and painful pressure points in the masseter and temporal muscles after of cervical manipulation compared to the control group.
- Trial name
- NCT05416788
- Testing
- cervical manipulation
- Where
- Chile
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Americas - Chili
Healthy
Pharmacokinetics And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers
To estimate the pharmacokinetics and relative bioavailability of oxycodone after administration of 40 mg doses of PF-00345439 formulations taken whole under fed conditions and after chewing under fasted conditions in healthy…
- Trial name
- NCT01717027
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Myofacial Pain Syndrome, Local Myalgia
Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain
The study group will be selected from patients who previously presented with various temporomandibular disorder (TMD) complaints to the "Temporomandibular Disorders Clinic" of the Department of Complete and Removable Dentures at…
- Conditions
- Myofacial Pain Syndrome, Local Myalgia, Masticatory Muscle Pain, Bruxism
- Trial name
- NCT07090551
- Testing
- occlusal splint therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pain, Postoperative
Equality Study of Ofirmev vs Oral Acetaminophen
Acetaminophen (Tylenol) is a drug that is used commonly for relief of mild to moderate pain. It is found in many pain medicines that people take after having surgery.
- Trial name
- NCT01711229
- Testing
- IV acetaminophen, oral acetaminophen
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Babiash, Kimberly H., M.D.
Pain
Characterization of the Analgesic Effect of CBD in Healthy, Normal Volunteers
The purpose of this double-blind, placebo-controlled study is to determine the analgesic effects of cannabidiol (CBD), a chemical constituent found in cannabis that does not have intoxicating effects.
- Trial name
- NCT02751359
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anesthesia, Local
Compare the Efficacy of Various Pain Alleviating Methods in Reducing Pain in Children During Intraoral Local Anaesthetic Injections
The aim of study is to compare the efficacy of various pain alleviating methods by application of Emla gel, TENS, and topical cooling of injection sites compared with 20% benzocaine gel in reducing pain in children requiring…
- Trial name
- NCT05564442
- Testing
- 20% benzocaine gel, Transcutaneous electric nerve stimuli, Emla gel
- Where
- Egypt
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Minia University
Pain
Evaluation of Analgesia With EMLA and Glucose Oral Solution
In this randomized controlled study the investigators intended to compare analgesic effects of EMLA and/or oral glucose in 60 preterm neonate during arterial function and PICC installation.
- Trial name
- NCT00808054
- Testing
- EMLA
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Pain
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain.
- Trial name
- NCT00115752
- Testing
- Valdecoxib, COX Inhibitor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)