Clinical trials: Oral Dysesthesia
Burning Mouth Syndrome
Impact of Alpha Lipoic Acid Efficacy in Burning Mouth Syndrome
A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of alpha lipoic acid (ALA) and determine the statistical significance of the outcome variables.
- Trial name
- NCT05729529
- Testing
- Lipoid acid gel
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Catania
Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
This study will test the effectiveness of topical thalidomide in healing mouth sores in HIV infected patients. Oral (PO) thalidomide heals these sores at a dose of 200 mg per day.
- Conditions
- Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome, HIV Infection
- Trial name
- NCT00001524
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Burning Mouth Syndrome
Burning Mouth Syndrome: Symptoms and Management
This research study aims to evaluate how an oral cooling spray, currently a commercial dietary supplement, impacts symptoms associated with burning mouth syndrome (BMS).
- Trial name
- NCT07016555
- Testing
- Oral cooling spray
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Amherst
Burning Mouth Syndrome, Progesterone
Hormonal Status and Quality of Life in Female Postmenopausal Patients With Burning Mouth Syndrome
The aim of this study was to determine the level of salivary estradiol, progesterone and dehydroepiandrosterone in female postmenopausal women with and without burning mouth syndrome.
- Conditions
- Burning Mouth Syndrome, Progesterone, Dehydroepiandrosterone, Quality of Life
- Trial name
- NCT04535973
- Testing
- unstimulated saliva sample for hormone analysis, quality of life questionnaire
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Burning Mouth Syndrome
Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome
Burning Mouth Syndrome (BMS) is characterized by a burning sensation on the tongue or other areas of the mouth, often bilateral but occasionally unilateral. It is more prevalent in postmenopausal women.
- Trial name
- NCT06040190
- Testing
- topical clonazepam rinse, oral alpha-lipoic acid capsule, topical phytotherapic capsaicin gel
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Minas Gerais
Oral Submucous Fibrosis
Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous Fibrosis
Oral Submucous Fibrosis (OSF) is a chronic, progressive, potentially malignant disorder characterized by mucosal stiffness, trismus, and burning sensation.
- Trial name
- RegenOSF (NCT07277998)
- Testing
- Platelet-Rich Plasma (PRP) Injections, Triamcinolone Acetonide
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Karachi Medical and Dental College
Burning Mouth Syndrome
Low Level Laser Therapy Plus Topical Clonazepam Treatment to Burning Mouth Symdrome
Burning mouth syndrome (BMS) is a condition that affects the oral mucosa; this is seen mainly in postmenopausal women. The intensity of burning and its clinical manifestations may be variable between patients.
- Trial name
- BurnLasCLo (NCT04313907)
- Testing
- low level laser therapy plus topical clonazepam
- Where
- Mexico
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Burning Mouth Syndrome
Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome
Background: The treatment of Burning Mouth Syndrome (BMS) presents a challenge in tailoring appropriate medication for individual patients.
- Trial name
- NCT06025474
- Testing
- Vortioxetine 20Mg Tab, Paroxetine 20 Mg Oral Tablet, Sertraline 50 MG
- Where
- Italy
- Volunteers
- 203 people
- Sponsor
- Federico II University
Caffeine, Burning Mouth Syndrome
Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)
The aim of this study was to evaluate the efficacy of caffeine and alpha-lipoic acid in the treatment of burning mouth syndrome by symptom assessment with visual analogue scale.
- Trial name
- NCT06195137
- Testing
- Caffeine, Alpha Lipoic Acid
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Lu Jiang
Burning Mouth Syndrome
Impact of Diazepam 1% Oral Gel Efficacy in Burning Mouth Syndrome
Burning mouth syndrome (BMS) is a syndrome characterized by burning and persistent oral pain, ranging from mild to intense, in the absence of organic disorders of the oral cavity and with a major impact on the quality of life of…
- Trial name
- NCT05872789
- Testing
- Diazepam 1% oral gel
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Burning Mouth Syndrome
Burning Mouth Syndrome - New Diagnostic Criteria and Treatment
The first part of this study is to optimize diagnostic criteria for BMS, i.e. not a clinical trial, and will not be covered in this application.
- Trial name
- BMS (NCT05059418)
- Testing
- Clonazepam 0.5 MG, Capsaicin Topical
- Volunteers
- 40 people
- Sponsor
- Malmö University
Burning Mouth Syndrome, Oral Mucosa Disease
Head Yuanshi Dian Therapy in Burning Mouth Syndrome
Burning mouth syndrome is one of the most common oral mucosal diseases in clinic. It is a chronic pain syndrome with extensive burning pain of oral mucosa as its main symptoms.
- Trial name
- NCT04481841
- Testing
- oryzanol + vitamin B2 (riboflavin) + vitamin E
- Where
- 3 sites in China
- Volunteers
- 290 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aphthous Stomatitis, Burning Mouth Syndrome
Evaluation and Treatment of Oral Soft Tissue Diseases
This study offers evaluation and treatment of patients with diseases of the mouth or systemic diseases that involve the mouth. The protocol is not designed to test new treatments; rather, patients will receive current standard of…
- Conditions
- Aphthous Stomatitis, Burning Mouth Syndrome, Lichen Planus, Mouth Disease
- Trial name
- NCT00001601
- Testing
- Electrocardiogram, Biopsies, Diagnostic imaging
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Burning Mouth Syndrome
Effects of Photobiomodulation in Burning Mouth Syndrome
The main objective of this study is to assess the effects of Photobiomodulation with Low-level Laser Therapy to the pain management in Burning Mouth Syndrome patients, besides assessing their impact on the different aspects of…
- Trial name
- NCT04034849
- Testing
- Photobiomodulation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Rosa María López-Pintor Muñoz
Burning Mouth Syndrome
Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome
What affect does the use of a mucoadhesive drug delivery system (Mucolox®) compounded with clonazepam have in the treatment of burning mouth syndrome? There are no clinical trials reported in the literature that evaluate the use…
- Trial name
- NCT02690844
- Testing
- Clonazepam mixed with Mucolox®, Mucolox® alone, Clonazepam
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Pain
Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain
The aim of the project is to do a fase two trial, where the effect of a local anesthetic lozenge will be tested in regard to oral pain, dryness of the mouth, irregularity of taste as well as investigate a potential…
- Trial name
- NCT01584947
- Testing
- Bupivacaine
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Hvidovre University Hospital
Burning Mouth Syndrome
The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study
Objectives: to evaluate xerostomia and salivary flow in patients with burning mouth syndrome (BMS) treated with amitriptyline before and after the use of antixerostomic topical medication.
- Trial name
- BMS (NCT01754740)
- Testing
- Uréia
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo General Hospital
Burning Mouth Syndrome, Melatonin
Salivary Melatonin Levels and Sleep Quality in Patients With Burning Mouth Syndrome
Burning mouth syndrome is an idiopathic condition characterized by symptoms burning and / or pain of the oral mucosa with an orderly clinical finding. So far not found a unique way of treatment.
- Trial name
- NCT05309681
- Testing
- Epworth's sleepiness scale; unstimulated saliva sample
- Where
- Croatia
- Volunteers
- 45 people
- Sponsor
- University of Zagreb
Burning Mouth Syndrome
Thermography and Burning Mouth Syndrome
Medical thermography is a noninvasive technique that allows an examiner to visualize and estimate the temperature of the body . This technique allows for an evaluation of the functionality of the structures, which is why it is…
- Trial name
- TDSBA (NCT05399238)
- Testing
- The objective is to measure the temperature of the lingual dorsum
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Murcia
Burning Mouth Syndrome
Botulinum Toxin in Burning Mouth Syndrome
The effect of botulinum neurotoxin type A intradermal injection in will be evaluated in 4 patients with clinical diagnosis of burning mouth syndrome involving the anterior two-thirds of the tongue and the lower lip for at least 6…
- Trial name
- NCT02964728
- Testing
- Botulinum Neurotoxin Type A, Normal saline
- Volunteers
- 6 people
- Sponsor
- Presidio Ospedaliero Garibaldi-Centro