Clinical trials: Oral Disorder
Periodontitis, Dual- Light Photodynamic Therapy
Use of Dual-light Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The goal of this controlled clinical trial is to investigate the impact of regular home use of Lumoral device as an adjunct treatment compared to non-surgical periodontitis treatment (NSPT) alone on biofilm removal and host…
- Conditions
- Periodontitis, Dual- Light Photodynamic Therapy, Smoking, Cigarette, Non-surgical Periodontal Therapy
- Trial name
- NCT05962801
- Testing
- Lumoral device, Lumorinse
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Dental Plaque
Evaluation of the Effect of Zinc Citrate Trihydrate Toothpaste on the Oral Plaque Microbiome
This study is of a double-blind, randomised, parallel group study. Subjects will be enrolled onto the study according to the inclusion/exclusion criteria.
- Trial name
- NCT06358742
- Testing
- ZCT toothpaste, Control toothpaste
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Cellulitis, Wound Infection
Penicillin for the Emergency Department Outpatient Treatment of CELLulitis
The main objective of this study is to investigate the non-inferiority of oral flucloxacillin alone compared with a combination of oral flucloxacillin and phenoxymethylpenicillin for the emergency department directed outpatient…
- Conditions
- Cellulitis, Wound Infection, Abscess
- Trial name
- PEDOCELL (NCT02922686)
- Testing
- Flucloxacillin, Phenoxymethylpenicillin
- Where
- 5 sites in Ireland
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Obesity
ERX1000 - Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Male and Female Subjects With Obesity
The primary objective is to assess the safety and tolerability of single and multiple oral doses of ERX1000 in obese subjects.
- Trial name
- NCT04890873
- Testing
- ERX1000
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- ERX Pharmaceuticals
Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction
Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis
The purpose of this study is to compare the effectiveness of three commercially available botulinum toxin neuromodulators in the treatment of facial synkinesis using patient reported outcome measures.
- Conditions
- Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction, Facial Asymmetry, Synkinesis
- Trial name
- NCT03048383
- Testing
- OnabotulinumtoxinA Injectable Product, AbobotulinumtoxinA Injectable Product, Incobotulinumtoxin A Injectable Product
- Volunteers
- 71 people
- Sponsor
- University of Utah
Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain
RATIONALE: Naloxone may be effective in treating constipation that may be caused by opioid pain medications such as morphine. PURPOSE: Phase III trial to determine the effectiveness of naloxone in relieving constiption in…
- Trial name
- NCT00020605
- Testing
- naloxone hydrochloride
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Periodontitis Stage II, Gingival Pocket
Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients
The objective of the present study is to assess the clinical effectiveness of local delivery of injectable extended platelet-rich fibrin in subgingival application when used in conjunction with scaling and root planing (SRP) in…
- Trial name
- NCT07080294
- Testing
- extended platelet rich fibrin injection in pocket, albumin injection in pocket, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Cancer-related Problem/Condition, Head and Neck Cancer
S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat
RATIONALE: Glutamine may be effective in decreasing side effects, such as inflammation of the mouth and throat, caused by radiation therapy. The effectiveness of glutamine for mucositis is not yet known.
- Conditions
- Cancer-related Problem/Condition, Head and Neck Cancer, Pain
- Trial name
- NCT00006994
- Testing
- glutamine, radiation therapy
- Where
- 107 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- SWOG Cancer Research Network
Idiopathic Parkinson's Disease
A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease
This is a study to assess the efficacy and safety of oral Istradefylline (KW-6002) in patients with moderate to severe Parkinson's Disease.
- Trial name
- KW-6002 (NCT01968031)
- Testing
- Istradefylline 40 mg, Istradefylline 20 mg
- Where
- 89 sites in United States, Canada and 6 more
- Volunteers
- 613 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Relapsed Malignant Solid Neoplasm
A Study Evaluating the Safety and Efficacy of AUR107 in Patients With Relapsed Advanced Malignancies (SHAKTI-1)
An open-label, first-in-human, Phase 1 study in adult patients with relapsed advanced malignancies will be done to assess AUR107 safety, tolerability, pharmacokinetics, pharmacodynamics, and optimal biological dose.
- Trial name
- NCT05865002
- Testing
- AUR107
- Where
- 37 sites in India
- Volunteers
- 50 people
- Sponsor
- Aurigene Discovery Technologies Limited
Candidiasis, Oral
Trial of Two Dosing Regimens of Micafungin Versus Caspofungin for the Treatment of Esophageal Candidiasis
To determine the efficacy and safety of daily doses of IV micafungin versus IV caspofungin for the treatment of esophageal candidiasis
- Trial name
- NCT00665639
- Testing
- micafungin, caspofungin
- Where
- 31 sites in Argentina, Brazil and 2 more
- Volunteers
- 454 people
- Sponsor
- Astellas Pharma Inc
Myofacial Pain Syndrome, Chronic Neck Pain
Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck Pain
Myofascial neck pain may involve several active trigger points in the neck and shoulder muscles. In clinical practice, it is not clear whether treating only the main trigger point that best reproduces the patient's pain is…
- Trial name
- NCT07876739
- Testing
- Lidocaine 1% Trigger Point Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mardin Artuklu University
Pregnancy-associated Gingivitis
A Study to Evaluate Associations Between Gingivitis and Pregnancy Outcomes
Compelling evidence suggesting a possible link between maternal pregnancy-related periodontitis (gum disease) and spontaneous pre-term birth (PTB)makes effective management of oral health a relevant and significant…
- Trial name
- TRIUMPH (NCT00641901)
- Testing
- counseling
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Xerostomia
Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
This will be a single center, 7-day, examiner blind, two treatment-arm, randomized, stratified (Sjogren's Syndrome status [Y/N]), parallel group study conducted in participants experiencing dry mouth symptoms.
- Trial name
- NCT02641912
- Testing
- Biotene mouthwash, Mineral Water
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
Study of Oral Fampridine-SR in Multiple Sclerosis
To assess the safety and efficacy of 10 milligram (mg) twice a day (b.i.d.) Fampridine-SR in patients diagnosed with multiple sclerosis (MS), in a double-blind, placebo-controlled, parallel group study.
- Trial name
- NCT00127530
- Testing
- Fampridine-SR
- Where
- 34 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Acorda Therapeutics
Myelodysplastic Syndromes, Anemia
Treatment of Anemia in Patients With Very Low, Low or Intermediate Risk Myelodysplastic Syndromes With CA-4948
Anemia in LR-MDS patients
- Trial name
- LUCAS (NCT05178342)
- Testing
- CA-4948
- Where
- 15 sites in Germany
- Volunteers
- 38 people
- Sponsor
- University of Leipzig
Alveolar Bone Loss Associated Chronic Periodontitis
Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis
This open label, randomized controlled clinical trial study will be conducted after obtaining ERC approval of Bahria University Health Sciences. Written informed consent will be taken from all study participants.
- Trial name
- NCT06856369
- Testing
- Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bahria University
Childhood Obesity, Adolescent Obesity
Effects of COcoa Supplement in OBese Adolescent Subjects
Childhood obesity is a serious public health problem internationally. In addition to being associated with the early onset of chronic degenerative diseases such as diabetes, dyslipidemias, coronary artery diseases, among others.
- Trial name
- COOBA (NCT04112251)
- Testing
- Cocoa Flavonols Supplement
- Where
- Mexico
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Periodontal Diseases, Inflammatory Response
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers for the diagnosis and prognosis of diseases.
- Trial name
- NCT03510702
- Testing
- Levels of epigenetic biomarkers present in the gingival fluid and its possible relationship with bone metabolism.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Head and Neck Cancer, Oral Mucositis
The Effect of Hydrogen Water in Oral Mucositis in Head and Neck Cancer Patients After Therapy
Inpatients or outpatients diagnosed with head and neck cancer who met the inclusion and exclusion criteria were referred to the co-investigator(Dr. Chih-Jen Huang and Dr.
- Conditions
- Head and Neck Cancer, Oral Mucositis, Pain, Quality of Life
- Trial name
- NCT05913895
- Testing
- hydrogen water
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital