Clinical trials: Oral Cavity Disease
Gingival Recession
Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT
Pinhole surgical technique is a novel minimally invasive, predictable, efficient, time and cost-effective technique for treatment of multiple gingival recession.
- Trial name
- NCT02632968
- Testing
- Pinhole surgery with and without buttons
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Oral Lichen Planus
Evaluation of Efficacy of Neem (Azadirachta Indica) Versus Triamcinolone Acetonide in the Treatment of Oral Lichen Planus.
The goal of this clinical trial is to learn if Neem works to treat Oral Lichen Planus in adults. It will also learn about the safety of Neem in oral lesions.
- Trial name
- NCT07141446
- Testing
- Neem gel, Triamcinolone Acetonide
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Goa Dental College
Oral Mucositis
The Protective Effect of Soluble Beta-1,3/1,6-Glucan Compared to Placebo in Oral Mucositis in Head and Neck Cancer Patients
The purpose of this study is to explore the protective effect and safety of soluble beta-1,3/1,6-glucan compared to placebo in oral mucositis in head and neck patients receiving radiotherapy or chemoradiotherapy.
- Trial name
- NCT00289003
- Testing
- Soluble beta-1,3/1,6-glucan
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Biotec Pharmacon ASA
HIV Infections, Pregnancy
A Study of Nevirapine for the Prevention of HIV Transmission From Mothers to Their Babies
The purpose of this study is to see if giving the anti-HIV drug nevirapine (NVP) to HIV-positive pregnant women and their babies can help reduce the chance that a mother will give HIV to her baby during delivery.
- Trial name
- NCT00000869
- Testing
- Nevirapine
- Where
- 72 sites in United States, Puerto Rico
- Volunteers
- 2,009 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
End Stage Renal Disease, Venous Stenosis
Sirolimus Use in Angioplasty for Vascular Access Extension
Dialysis patients presenting for angioplasty intervention for graft failure will be randomized to receive either Sirolimus or not receive Sirolimus (standard of care) to assess the time from primary failure or angioplasty…
- Trial name
- SAVE (NCT01595841)
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Neuropathic Pain
Study of MRgFUS Exablate Treatment Following the Neuropathic Pain
The objective of this study is to capture the change in pain intensity, physical/emotional function, and pain impact for patients diagnosed with neuropathic pain who undergo an Exablate treatment.
- Trial name
- NCT04649554
- Testing
- Exablate treatment
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- InSightec
Toothbrushing, Gingivitis
Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery
The study is a randomized clinical trial to compare the effectiveness of a dual light ultrasonic toothbrush on periodontal health in orthodontic patients undergoing surgery.
- Conditions
- Toothbrushing, Gingivitis, Cleft Lip and Palate
- Trial name
- NCT06122805
- Testing
- Toothbrush
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Radiation-Induced Xerostomia and Hyposalivation
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult patients with radiation-induced xerostomia (dry mouth) and…
- Trial name
- SPRINX-1 (NCT06714253)
- Testing
- RXRG001
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- RiboX Therapeutics Ltd.
Non-Alcoholic Fatty Liver Disease, Liver Fibrosis
Study in Healthy Adults Evaluating PF-07202954
The study is planned as a 3 part design with investigator and participant blinded (sponsor-open), placebo controlled, randomized, dose escalation in Part 1 and Part 2; and a randomized, open label design, in Part 3 (if conducted).
- Trial name
- NCT04857437
- Testing
- PF-07202954 Repeat Dose, PF-07202954 Single Dose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Periodontal Disease
Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis
The aim of this study is to evaluate the effects of adjunctive synbiotic supplementation combined with non-surgical periodontal therapy in smokers with periodontitis.
- Trial name
- NCT07672379
- Testing
- Synbiotic supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Biruni University
Oral Cancer
Analysis Of Sensory Recovery Of Donor Size And Quality Life In Oral Cancer Patients
The aim of the study is to investigate post-surgery sensory impairment and life quality changes in oral cancer patients who underwent free flap (Free Flap) on post-operative 6 months, 12 months, and 24 months, respectively
- Trial name
- NCT02048631
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Peri-Implantitis
SPIC Frequency After Surgical Treatment of Peri-implantitis
The leading hypothesis behind this study is that a 3-month frequency of supportive peri-implant care (SPIC) recalls after surgical therapy of implants affected by severe peri-implantitis yields better results when compared to a…
- Trial name
- NCT06762353
- Testing
- 3-month supportive peri-implant care (SPIC), 6-month supportive peri-implant care (SPIC)
- Volunteers
- 152 people
- Sponsor
- University of Turin, Italy
Head and Neck Cancer, Pain
Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer
RATIONALE: Acupuncture may help relieve pain and dysfunction caused by cancer surgery. It is not yet known whether acupuncture is more effective than standard therapy in treating pain and dysfunction in patients who have…
- Trial name
- NCT00090337
- Testing
- acupuncture therapy, standard follow-up care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Periodontitis
SRP, Systemic Inflammation and Serum Bone Resorption Markers Premenopausal Women With Periodontitis and Low BMD
To assess the impact of scaling and root planing on systemic inflammation and serum bone resorption markers in pre-menopausal women with periodontitis
- Trial name
- NCT04259242
- Testing
- SRP
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Celiac Disease
Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease
Oral supplementation with enzymes that can cut gluten has been suggested as a potential treatment modality for coeliac disease. In the present study the investigators wish to determine if co-administration of such an enzyme, a…
- Trial name
- NCT00810654
- Testing
- Aspergillus niger prolyl endoprotease
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Amsterdam UMC, location VUmc
Gingival Recession, Localized, Sensitivity, Tooth
Two Different Graft Harvesting Techniques Applied in Localized Gingival Recessions
The primary purpose of this study is to compare the root coverage rate of the gingival unit-shaped connective tissue graft, obtained by intraoral de-epithelization, with the traditional de-epithelialized free gingival graft in…
- Conditions
- Gingival Recession, Localized, Sensitivity, Tooth, Attachment Loss, Periodontal
- Trial name
- NCT05923294
- Testing
- Coronally advanced flap with connective tissue graft
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Gingivitis
Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT
Frankincense, a natural resin obtained from trees of the Boswellia genus, has been traditionally used for its medicinal properties.
- Trial name
- FHEPIG (NCT07535229)
- Testing
- Frankinscence and coconut Oil based mouthwash, Frankinscence and Thyme essence/ water based mouthwash, Chlorhexidine (0.2%)
- Where
- Oman
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Oman Dental College
Non-alcoholic Steatohepatitis, Fibrosis
Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis
This is a multicenter, double-blind, randomized, placebo-controlled trial involving subjects with a diagnosis of "definite NASH" with fibrosis (excluding cirrhosis) as determined by the central histopathologist.
- Conditions
- Non-alcoholic Steatohepatitis, Fibrosis, Liver Diseases
- Trial name
- ENCORE-NF (NCT02686762)
- Testing
- Emricasan (5 mg), Emricasan (50 mg)
- Where
- 103 sites in United States, Germany and 1 more
- Volunteers
- 318 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Herpes Labialis
Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents
The Purpose of this study is to evaluate the safety of ME-609 for the treatment of recurrent herpes labialis in adolescents.
- Trial name
- NCT00375570
- Testing
- ME-609
- Volunteers
- 254 people
- Sponsor
- Medivir
Peri Implantitis, Peri Implant Mucositis
Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus Fluid
Despite technological advances that have significantly improved dental implant osseointegration and survival rates, biological complications such as peri-implantitis and peri-implant mucositis are common around the implant.
- Trial name
- NCT07280754
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
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