Clinical trials: Optical Coherence Tomography
Dry Age-related Macular Degeneration
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE II)
This LIGHTSITE II study is a double-masked, sham-controlled, parallel design, prospective multi-site study for the use of PBM as a treatment for visual impairment in subjects with dry AMD.
- Trial name
- NCT03878420
- Testing
- Valeda PBM treatment
- Where
- 8 sites in France, Germany and 3 more
- Volunteers
- 44 people
- Sponsor
- LumiThera, Inc.
Hemodynamics, Coronary Circulation
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance
The study will compare two invasive methods (FFR -fractional flow reserve and iFR-instantaneous wave free ratio) for assessment of hemodynamic impact of coronary stenosis on myocardial perfusion.
- Conditions
- Hemodynamics, Coronary Circulation, Tomography, Optical Coherence, Endothelial Cells
- Trial name
- FiGARO (NCT03033810)
- Testing
- Fractional flow reserve and instantaneous wave-free ratio
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- General University Hospital, Prague
Strabismus, Tomography, Optical Coherence
Measurement of Insertion of Extraocular Muscles Using Anterior Segment Optical Coherence Tomography
Study designed to determine the ability and accuracy of anterior segment optical coherence tomography (AS-OCT) to measure the distance between the corneoscleral limbus and the insertion site of the extraocular muscles (EOM) in…
- Trial name
- NCT02454920
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Miami
VKH Syndrome
Oral Prednisolone Versus Posterior Sub-Tenon Triamcinolone for Acute Ocular VKH
Vogt-Koyanagi-Harada (VKH) disease is a rare autoimmune disorder characterized by bilateral ocular inflammation that may lead to serous retinal detachment and permanent visual impairment if not promptly treated.
- Trial name
- VKH-OC (NCT07405489)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Acute Myocardial Infarction
OPTical Coherence Tomography IMAging in Patients With Acute myocardiaL Infarction (OPTIMAL)
The purpose of the study is to investigate the clinical outcomes, safety and cost-effectiveness of intravascular OCT imaging in patients with acute myocardial infarction undergoing percutaneous coronary intervention (PCI).
- Trial name
- OPTIMAL (NCT03084991)
- Where
- 20 sites in China
- Volunteers
- 4,500 people
- Sponsor
- Harbin Medical University
Diabetic Retinopathy, Periodontitis
Periodontitis Severity in Patients With Diabetic Retinopathy
The aim of this observational study is to investigate the relationship between periodontal disease severity and retinal layer thickness in patients diagnosed with diabetic retinopathy (DR), using optical coherence tomography…
- Trial name
- NCT07137013
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Dry Eye Syndromes
Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography
Dry eye is a common condition that affects vision and quality of life in patients. Dry eye clinical research is limited to follow up of disease progression.
- Trial name
- NCT01479790
- Testing
- EyeGiene
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Skin Diseases, Healthy Skin
An Observational Study to Assess Objective Skin Pigmentation Variation.
Accurate assessment of skin pigmentation is essential in dermatology for properly diagnosing and managing a wide range of skin conditions.
- Trial name
- SKIN-IMAGING (NCT07091604)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Coronary Artery Disease
Invasive Measurement of Axial Plaque Stress, the Pilot Study
In this study, the investigators sought to evaluate the feasibility of estimating external hemodynamic stress acting plaque with the use of invasively measured hemodynamic data from pressure wire pullback tracing.
- Trial name
- REASSURE (NCT02388399)
- Testing
- Device
- Where
- 4 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Normal Tension Glaucoma
Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG
The purpose of this study is to evaluate the effect of Ginkgo biloba extract (GBE) on the number of blood vessels in the back of the eye as well as the amount of blood flow at the nailfold(where the fingernail meets the skin) of…
- Trial name
- NCT03761992
- Testing
- Gingko Baloba
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Robert Ritch, MD, LLC.
Dry Eye Syndromes
Assessment of TFT by OCT in Healthy Subjects and Subjects With DES
Dry eye syndrome (DES) is a highly prevalent ocular condition with potential severe consequences for affected patients. DES can be either caused by decreased tear production or increased tear evaporation, both leading to an…
- Trial name
- NCT02585414
- Where
- Austria
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Erectile Dysfunction Following Radical Prostatectomy
Study of Retinal and Choriocapillary Vascular Changes in Patients Undergoing Tadalafil 20mg
This study evaluates the retinal and choriocapillary vascular features in patients under the effects of Tadalafil 20mg using optical coherence tomography angiography.
- Trial name
- NCT04164355
- Testing
- Tadalafil 20 MG
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Multiple Sclerosis
Assessment of NfL and GFAP Levels, Atrophy of the Macula GCC by OCT and Whole Brain Atrophy by MRI to Predict Evolution of Neurological Disability in MS Patients
The investigators hypothesize that serum neurofilament-light chain (NfL) levels at baseline and decrease of the macular ganglion cell complex (GCC) thickness at one year vs.
- Trial name
- NFL OCT (NCT04860947)
- Testing
- Brain MRI, Spinal Cord MRI, Retinal imaging
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coronary Artery Disease, Angina Pectoris
PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX)
The aim of the study is to compare post-interventional fractional flow reserve (FFR) value between optical coherence tomography(OCT)-guided and angiography-guided strategy for treatment of complex coronary lesion.
- Trial name
- NCT05493904
- Testing
- OCT-guided PCI, Angiography-guided PCI, Drug-eluting stent
- Where
- 4 sites in South Korea
- Volunteers
- 320 people
- Sponsor
- Chonnam National University Hospital
Effects of the External Testosteron Intake Over the Choroids of the Patients With Androgen Deficiency
Effects of External Testosteron Intake on the Choroid: Enhance-depth Imaging Optical Coherence Tomography Study
According to the results Ciloğlu et al., CSC is related to elevated total testosterone levels. Testosterone may play a role in predisposing males to CSC.
- Trial name
- NCT04342247
- Testing
- external testosteron
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neon Hospital
Basal Cell Carcinoma
Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma
Optical coherence tomography (OCT) is an imaging technique which shows the internal structure of living tissue (in vivo). It is safe, quick and painless to perform, and does not damage the tissue in any way.
- Trial name
- NCT01603810
- Testing
- OCT
- Where
- United Kingdom
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Coronary Atherosclerosis, Endothelial Dysfunction
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography
The investigator's hypothesis is that local activation of the endogenous Lp-PLA2 plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and…
- Conditions
- Coronary Atherosclerosis, Endothelial Dysfunction, Coronary Small Vessel Disease
- Trial name
- NCT01642173
- Testing
- Optical Coherence Tomography (C7 XR Dragonfly )
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Choroid Disease, Diabetes Mellitus
Measuring Choroidal Thickness Using Optical Coherence Tomography
To compare the choroidal thickness in eyes of diabetic patients with eyes of age matched controls using optical coherence tomography.
- Trial name
- NCT06272851
- Testing
- optical coherence tomography
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Ischemic Heart Disease
Yonsei OCT (Optical Coherence Tomography) Registry for Evaluation of Efficacy and Safety of Coronary Stenting
Optical coherence tomography (OCT) has been recently studied for evaluation of coronary stenting. Because of high resolutions, several reports have shown that OCT is appropriate for evaluating neointimal tissue after coronary…
- Trial name
- NCT02099162
- Testing
- coronary stents
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Yonsei University
Healthy
OCT Reference Database
To collect data for a reference database.
- Trial name
- NCT01986478
- Where
- 5 sites in United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.