Clinical trials: Optical Coherence Tomography
Diabetic Macular Edema, Pars Plana Vitrectomy
Compare the Efficacy of VItrectomy Combined With DExamethasone Implant Versus With Aflibercept in DME Patients Diagnosed by Intraoperative OCT (the VIDEO Study): Study Protocol for a Randomized Controlled Trial
Diabetic macular edema (DME) is the main cause of severe vision loss in diabetic retinopathy. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) and Ozurdex are two safe and effective ways to treat DME.
- Conditions
- Diabetic Macular Edema, Pars Plana Vitrectomy, Dexamethasone Intravitreal Implant, Intraoperative Optical Coherence Tomography
- Trial name
- NCT05990829
- Testing
- Ozurdex, Aflibercept
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tianjin Medical University Eye Hospital
Vascular Calcification* / Diagnostic Imaging, Atherectomies, Coronary
Calcium Reduction by Orbital Atherectomy in Western Europe
In calcified lesions, optimal stent placement and expansion may prove to be challenging. Lesion preparation is necessary to facilitate optimal stenting in calcified lesions, for which orbital atherectomy can used.
- Conditions
- Vascular Calcification* / Diagnostic Imaging, Atherectomies, Coronary, Tomography, Optical Coherence, Coronary Intervention, Percutaneous
- Trial name
- CROWN (NCT06035783)
- Testing
- Orbital Atherectomy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Optical Coherence Tomography, Artificial Intelligence
Repeatability and Stability of Healthy Skin Features on OCT
A test-retest study on the stability and repeatability of healthy skin features on OCT
- Conditions
- Optical Coherence Tomography, Artificial Intelligence, Radiomics
- Trial name
- NCT05517889
- Testing
- Optical coherence tomography
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma, Optical Coherence Tomography
AI-aided Optical Coherence Tomography for the Detection of Basal Cell Carcinoma
Basal cell carcinoma (BCC) is the most common form of cancer among the Caucasian population. A BCC diagnosis is commonly establish by means of an invasive punch biopsy (golden standard).
- Trial name
- NCT05817279
- Testing
- Optical coherence tomography
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma, Tomography, Optical Coherence
Structural Description of Skin Biopsies With Dynamic Full-field Optical Coherence Tomography on Suspected Basal Cell Carcinoma Lesions, a Pilot Study (DOCTOBA)
Basal cell carcinoma (BCC) are the most frequent skin cancers. Their incidence is constantly increasing. BCC diagnosis is first clinically suspected and then confirmed following histological examination of either a skin biopsy or…
- Trial name
- DOCTOBA (NCT05608902)
- Testing
- Dynamic full-field optical coherence tomography analysis of skin biopsy or resection
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Tomography, Optical Coherence, Kidney Transplantation
Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Kidney Transplant Recipients (HARBOR)
Banff classification stands as gold standard and international consensus for the identification, diagnosis and categorization of renal allograft pathology.
- Trial name
- HARBOR (NCT05635136)
- Testing
- Dynamic full-field optical coherence tomography analysis of kidney transplant biopsy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Macular Holes, Optical Coherence Tomography
Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness Idiopathic Macular Holes < 600 μm With Air Versus 10% SF6 Tamponade
State of the art treatment for idiopathic macular holes consists of pars plana vitrectomy, internal limiting membrane staining with a blue colouring dye, internal limiting membrane peeling and filling of the vitrectomized space…
- Trial name
- NCT05223205
- Testing
- Air, 10% SF6 and 90% air
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Tomography, Optical Coherence, Bronchoscopy
Measure Airway Compliance by Endobronchial Optical Coherence Tomography
Optical Coherence Tomography （OCT）is a novel, non-invasive, high resolution special optical imaging techniques. In airway, Measure airway area and airway wall thickness is the most usage of Endobronchial Optical Coherence…
- Conditions
- Tomography, Optical Coherence, Bronchoscopy, Respiratory Disease, Airway Remodeling
- Trial name
- NCT05692362
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Intracranial Atherosclerosis, Optical Coherence Tomography
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
- Conditions
- Intracranial Atherosclerosis, Optical Coherence Tomography, Plaque, Atherosclerotic, Artery Stenosis
- Trial name
- OCT-ICAS (NCT05550077)
- Testing
- Optical Coherence Tomography, Percutaneous transluminal angioplasty and stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- jiaoliqun
Glaucoma, Primary Open Angle, Ocular Blood Flow
The Effect of Topical Brimonidine on the Ocular Hemodynamics in Patients of POAG Using OCTA
Topical Brimonidine is a well-established topical antigalucoma, ocular hypotensive therapeutic that has been in use since 1996. Brimonidine stands out among other topical ocular hypotensives in that it has a neuroprotective…
- Conditions
- Glaucoma, Primary Open Angle, Ocular Blood Flow, Optical Coherence Tomography Angiography
- Trial name
- NCT05474716
- Testing
- Brimonidine tartrate 0.2% ophthalmic solution
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Fayoum University
Multiple Sclerosis, Pathologic Processes
Disability, MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination
Knowledge of the evolution of multiple sclerosis (MS) and its long-term prognostic factors is essential to guide the therapeutic management.
- Conditions
- Multiple Sclerosis, Pathologic Processes, Tomography, Optical Coherence, Magnetic Resonance Imaging
- Trial name
- DB-SEP15 (NCT03268096)
- Testing
- Cerebral MRI and Optical Coherence Tomography
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cutaneous Tumor, Optical Coherence Tomography
Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)
This project aims to validate ex vivo the use of the OCTAV® prototype integrating the "dermoscope" function before an in vivo application, by comparing images obtained by the OCTAV® prototype integrating the "dermoscope" function…
- Conditions
- Cutaneous Tumor, Optical Coherence Tomography, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- DERMOCTAV (NCT05340543)
- Testing
- Confocal optical coherence tomography - OCTAVE
- Where
- France
- Volunteers
- 150 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
Basal Cell Carcinoma, Optical Coherence Tomography
Optical-Coherence Tomography for the Non-invasive Diagnosis and Subtyping of Basal Cell Carcinoma
Rationale: To date, the diagnosis and subtyping of basal cell carcinoma (BCC) is verified with histopathology which requires a biopsy.
- Conditions
- Basal Cell Carcinoma, Optical Coherence Tomography, Deep Learning, Artificial Intelligence
- Trial name
- OCT-BCC (NCT05041777)
- Testing
- Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 963 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Optical Coherence Tomography
A Single Center Registry of Coronary OCT
This registry started January 1,2020 to collect patients who recieve coronary OCT imaging in Hainan General Hospital.All enrolled patients will receive 1 year followed-up.
- Conditions
- Coronary Artery Disease, Optical Coherence Tomography, Registry
- Trial name
- NCT04855500
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hainan People's Hospital
Chronic Total Occlusion of Coronary Artery, Optical Coherence Tomography
Post-stenting Assessment of Reendothelialization With OFDI After CTO Procedure (PERFECTO)
The objective of PERFECTO is to assess the reendothelialization at 3 months after successfully CTO percutaneous intervention (PCI) with new generation drug eluting stent (DES) by OFDI analysis.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Optical Coherence Tomography, Ischemic Cardiomyopathy, Neointimal Hyperplasia
- Trial name
- PERFECTO (NCT03209843)
- Testing
- Percutaneous recanalization of chronic total occlusion
- Where
- 7 sites in France
- Volunteers
- 122 people
- Sponsor
- Poitiers University Hospital
Basal Cell Carcinoma, Optical Coherence Tomography
(Cost)-Effectiveness of Optical Coherence Tomography (OCT) in Basal Cell Carcinoma (BCC)
A multi-centre randomized non-inferiority trial investigating the (cost-)effectiveness of Optical Coherence Tomography (OCT) versus regular punch biopsy in the diagnosis and subtyping of Basal Cell Carcinoma (BCC).
- Trial name
- ROCTI (NCT03848078)
- Testing
- Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 598 people
- Sponsor
- Maastricht University Medical Center
Tomography, Optical Coherence, Myocardial Revascularization
The FAST OCT Study
This trial is designed to associate angiography-based fractional flow reserve (3D-angio-based FFR) values with optical coherence tomography findings in pre- and post-percutaneous coronary intervention in patients with non-ST…
- Conditions
- Tomography, Optical Coherence, Myocardial Revascularization, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT04683133
- Testing
- Optical coherence tomography assessment
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Optical Coherence Tomography Glaucoma
"Predicting Glaucoma Progression With Optical Coherence Tomography Structural and Angiographic Parameters".
to predict of glaucoma progression. By imaging of the retinal nerve fiber layer RNFL, optic nerve head (ONH) and macular measurements using spectral-domain OCT (SD-OCT) instruments ,and detection of optic disc perfusion changes…
- Trial name
- NCT04646122
- Testing
- Optical Coherence Tomography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Percutaneous Coronary Intervention, Myocardial Revascularization
FANTOM ENCORE Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study
Prospective, multicentre, non-randomized, investigator-initiated study aiming to assess the safety and efficacy of the Fantom Encore sirolimus-eluting bioresorbable scaffold (BRS).
- Conditions
- Percutaneous Coronary Intervention, Myocardial Revascularization, Tomography, Optical Coherence
- Trial name
- NCT04591938
- Testing
- Fantom Encore Bioresorbable scaffold implantation
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 50 people
- Sponsor
- Joost Daemen