Clinical trials: Opioids
Neonatal Opiate Withdrawal Syndrome
Optimizing Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome (OPTimize NOW): A Symptom-Based Dosing Approach
This clinical trial will help us learn more about how to best care for babies with Neonatal Opioid Withdrawal Syndrome, also called NOWS.
- Trial name
- OPTimize NOW (NCT05980260)
- Testing
- Symptom-based Dosing Approach, Scheduled Opioid Taper Approach
- Where
- 23 sites in United States
- Volunteers
- 626 people
- Sponsor
- HELP for NOWS Consortium
Pain
A Pharmacokinetic and Safety Study of Osmotic Release Oral System (OROS) Hydromorphone in Non-Opioid Tolerant Chinese Participants With Cancer
The purpose of this study is to assess the single dose pharmacokinetic profile (explores what a drug does to the body) and safety of Osmotic Release Oral System (OROS) hydromorphone in chinese participants with cancer (abnormal…
- Trial name
- NCT01824524
- Testing
- Hydromorphone
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Substance Abuse
Substance Abuse Treatment for High Risk Chronic Pain Patients on Opioid Therapy
Chronic back pain patients are often dismissed from a pain center or a primary care practice when they are noncompliant with opioid therapy, instead of being offered treatments to reduce misuse and to improve compliance.
- Trial name
- NCT00988962
- Testing
- cognitive behavioral training
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Brigham and Women's Hospital
Acute Pathology of the Locomotor System
Impact of a Personalized Medication Plan on Duration of Treatment With Potent Opioids in Acute Non-cancer Musculoskeletal Pain.
The aim of this study is to evaluate whether patients who benefit from a personalized pharmaceutical plan (PPP) during their hospitalization, allowing them to be informed and sensitized, are treated for a shorter period of time…
- Trial name
- PPPCARE II (NCT05905146)
- Testing
- personalized pharmaceutical plan
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Substance-Related Disorders
Abuse Liability of Controlled-Release Oxycodone Formulations
The objective of this study is to examine the abuse liability of a single 40mg dose of 2 controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent recreational opioid users by assessing the…
- Trial name
- NCT02101840
- Testing
- Apo-Oxycodone CR®, OxyNEO®
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Pain, Chronic, Opioid Use Disorder
Pain and Opioid Management in Older Adults
The extent and depth of the ongoing opioid crisis are well known and many interventions are under way in the United States and other countries to alleviate its devastating impact on individuals and the society.
- Trial name
- RISE-OK (NCT05037682)
- Testing
- Dissemination and Implementation Research
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- University of Oklahoma
Nicotine Use Disoder, Opioid Use Disorder
Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder
This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes.
- Trial name
- FLAVOR (NCT07594717)
- Testing
- Sweet-cooling, Sweet non-cooling EC flavor, Tobacco flavor EC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Prisma Health-Upstate
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Congenital Heart Defect, Congenital Heart Disease
Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER) Study
The erector spinae plane block is a novel regional anesthetic technique that allows for analgesia of the thorax and abdomen with a peripheral nerve block.
- Conditions
- Congenital Heart Defect, Congenital Heart Disease, Anesthesia, Local, Opioid Use
- Trial name
- NCT03611374
- Testing
- Bilateral Erector Spinae Plane Block (ESPB)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
Chronic Pain, Prescription Opioid Misuse
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
The primary aim of this implementation-effectiveness trial is to examine the effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) and patient-centered chronic pain management visits in primary care as interventions…
- Conditions
- Chronic Pain, Prescription Opioid Misuse, Substance-Related Disorders, Pain
- Trial name
- NCT06387290
- Testing
- Mindfulness Oriented Recovery Enhancement, Patient-Centered Chronic Pain Management Visits
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Organ Dysfunction, Organ Support
Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction
Acute pancreatitis may cause early respiratory, cardiovascular, or renal dysfunction and may require intensive care and organ support.
- Conditions
- Organ Dysfunction, Organ Support, Acute Pancreatitis (AP)
- Trial name
- TEA-APOD (NCT07697690)
- Testing
- Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia
- Volunteers
- 150 people
- Sponsor
- First People's Hospital of Chenzhou
Pain
Opioid and Cannabinoid Pharmacokinetic Interactions
We are conducting a study to assess whether smoking marijuana affects the safety of prescribed opioids in patients treated for chronic pain.
- Trial name
- NCT00308555
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
ACL Reconstruction (ACLR) With a Bone-patellar Tendon-bone (BPTB) Autograft
Cryoneurolysis in Anterior Cruciate Ligament Reconstruction (ACLR)
The purpose of this research study is to assess whether cryoneurolysis will help control pain after ACLR surgery and decrease the need of opioid medications.
- Trial name
- NCT07731178
- Testing
- Pacira Iovera Cryoneurolysis device
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Back Pain, Neck Pain
A Naturalistic Experiment Evaluating the Impact of Medicaid Treatment Reimbursement Changes on Opioid Prescribing and Patient Outcomes Among Patients With Back Pain
Back on Track is a quasi-experimental, mixed-methods study of a unique natural experiment that will answer the question: what is the comparative effectiveness of different payer or health-system strategies that aim to prevent…
- Trial name
- Back on Track (NCT03393143)
- Where
- United States
- Volunteers
- 2,748 people
- Sponsor
- Kaiser Permanente
Opioid Dependence
Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population
The primary objective of this study is to compare overall patient preference for either Suboxone® sublingual film 8/2 or Zubsolv® sublingual tablets 5.7/1.4.
- Trial name
- NCT02038790
- Testing
- Suboxone Sublingual Film, Zubsolv sublingual tablets
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Indivior Inc.
Opioid Consumption, Postoperative
Postoperative Opioid Consumption of Serratus Posterior Superior Intercostal Plane Block Versus Thoracic Paravertebral Block
Previous studies found that paravertebral and thoracic epidural continuous infusions of opioid-free local anaesthetic were found to be comparable, but paravertebral analgesia (PVA) was associated with less respiratory…
- Trial name
- NCT07613697
- Testing
- Serratus Posterior Superior Intercostal Plane Block (single injection), Thoracic Paravertebral block (single injection)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Implicite Memorization
Dreams or Implicite Memorization Under OFA
The Dreams study is an observational study aimed at evaluating the incidence of connected awareness after intubation, intraoperative explicit and implicit memorization, and postoperative well-being in patients receiving general…
- Trial name
- Dreams (NCT06822660)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Pain and Anterior Cruciate Ligament Reconstruction
Effectiveness of Dry Needling and STM on Pain Management for Anterior Cruciate Ligament Reconstruction (ACLR)
The purpose of this study is to determine if dry needling (DN) and soft tissue mobilization (STM) is superior to standard treatment protocol for affecting pain, pain medication usage and measurements of range of motion (ROM)…
- Trial name
- NCT03506685
- Testing
- Dry needling and STM
- Where
- United States
- Sponsor
- Keller Army Community Hospital
Postoperative Pain, Sternotomy
Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is associated with significant intraoperative and postoperative pain, often requiring substantial opioid administration.
- Conditions
- Postoperative Pain, Sternotomy, Opioid Consumption, Intraoperative Pain Control
- Trial name
- NCT07315308
- Testing
- Deep Parasternal Intercostal Plane Block, Standard Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Spinal Curvatures
Amantadine Sulphate Usage in Spine Deformities Corrective Surgeries Patients
During the surgical procedure of scoliosis correction, large surgery extent and long-lasting strong nociceptive stimulation lead to postoperative pain formation of greater intensity compared with other orthopedic interventions.
- Trial name
- NCT03178708
- Testing
- Group A amantadine sulfate, Group B ringer lactate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University