Clinical trials: Opioid-free Anesthesia
Obesity, Pain, Postoperative
Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
The opioid consumption has exploded in the western world, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could…
- Trial name
- OS-PCC (NCT03756961)
- Testing
- Dexmedetomidine, Person-centred care (PCC), Esketamine
- Where
- 2 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Göteborg University
Opioid-free Anesthesia
COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA
This study is a randomized, double-blind controlled clinical trial designed to evaluate the effects of opioid-free anesthesia (OFA) compared with opioid-based anesthesia (OBA) in adult patients undergoing elective abdominal…
- Trial name
- OFA-OBA (NCT07310524)
- Testing
- Non Opioid Analgesics
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Muhammad Rahman Efendi Nasution
Opioid-Free Anesthesia, Laparoscopic Sleeve Gastrectomy
Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy
The purpose of the intraoperative use of opioids is to reduce the amount of sedative medication and to ensure effective analgesia.
- Conditions
- Opioid-Free Anesthesia, Laparoscopic Sleeve Gastrectomy, Postoperative Vomiting, Postoperative Recovery
- Trial name
- NCT06305221
- Testing
- Opioid-free Analgesics (esketamine, dexmedetomidine), Opioid Anesthetics (sufentanil and remifentanil)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Beijing Friendship Hospital
Anesthesia, Local, Surgery
Regional Anesthesia Block in Fibula Free Flap Reconstruction
Despite many recent advances in pain management, post-operative pain is widely considered to be poorly managed. Furthermore, the mainstay of current pain management is opioids, for which there is strong evidence of ill effects…
- Conditions
- Anesthesia, Local, Surgery, Opioid Use, Pain, Postoperative
- Trial name
- NCT03906838
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Intravenous Anesthesia
Opioid Based Anaesthesia vs Opioid Free Anesthesia in Cleft Lip, Palate ,Alveolus Surgery.
Peri-operative opioid administration has long been one of the three pillars of 'balanced anaesthesia',over the span of just a few years,opioids were widely used in perioperative analgesia because of pain as the fifth vital…
- Trial name
- NCT04081909
- Testing
- Fentanyl，Remifentanil, Ketamine,Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Analgesics, Opioid, Anesthesia, General
Asleep Fiberoptic vs Direct Laryngoscopy Effect on Hemodynamic Stability Using Opioid Free Anesthesia Induction
The goal of this clinical trial is to compare heart rate between the fiberoptic and direct oral intubation using opioid free anesthesia induction.
- Conditions
- Analgesics, Opioid, Anesthesia, General, Heart Rate, Blood Pressure
- Trial name
- NCT06487988
- Testing
- direct conventional laryngoscopy, fiberoptic guided intubation
- Where
- Lebanon
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Anesthesia
Opioid Free Anesthesia and Continuous Post-operative Pulse Oximetry Monitoring in the Obese Patient
Anaesthesia has three major components, analgesia, muscle relaxation and hypnosis. For a long time, opioids have been covering the analgesia function.
- Trial name
- NCT03124680
- Testing
- Opioid free, opioid group
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Université Libre de Bruxelles
Anesthesia, Opioid Use
PROUD Study - Preventing Opioid Use Disorders
The objective of this study is to pilot an opioid free anesthetic protocol for patients undergoing total hip replacement.
- Trial name
- NCT04766996
- Testing
- Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Analgesic Drug Dependence, Colectomy
Opioid Free Anesthesia vs. Opioid Anesthesia Techniques.
A comparison of post-operative opioid use in Laparoscopic Colectomy patients receiving Opioid or Opioid-free Anesthesia.
- Trial name
- OFA vs OA (NCT03367988)
- Testing
- Opioid Anesthesia, Opioid-free Anesthesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Supratentorial Neoplasms
Opioid Free VS Opioid Anesthesia for Craniotomies
Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia…
- Trial name
- NCT04941040
- Testing
- Opioid free anesthetics, Opioid Anesthetics
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Supra-tentorial Tumor
A Comparative Study Between Opioids Free Anesthesia and Opioid Anesthesia in Patients With Supratentorial Tumor Resection
Anesthesia for cranial surgeries is charactarized by periods of unpleasant stimuli interspersed with periods of low stimulation, which may compromise hemodynamic regulation.
- Trial name
- NCT06791811
- Testing
- OFA, OA
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Kasr El Aini Hospital
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Deviated Septum, Opioid Free Anesthesia
Opioid Free Versus Opioid Based General Anesthesia in Septoplasty Under Nociception Level Guidance
Prospactive observational Clinical study
- Trial name
- NCT07786727
- Testing
- OFA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Functional Endoscopic Sinus Surgery
Opioid Free Anesthesia in ENT Surgery
Opioid Free Anesthesia (OFA) - which has been applied mainly in bariatric surgery - has begun to receive more and more attention and to obtain fanatical supporters versus conventional anesthesia.
- Trial name
- NCT04105946
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Colorectal Cancer
Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding…
- Trial name
- NCT06042816
- Testing
- Free-opioid anesthesia, opioid anesthesia
- Where
- Vietnam
- Volunteers
- 49 people
- Sponsor
- Vietnam Military Medical University
Hip Arthropathy
Impact of Opioid Free Anesthesia on Outcome After Hip Arthroplasty by Direct Anterior Approach.
all patients with a first anterior arthroplasty, give their informed consent to be randomized to control or study protocol. control means no high steroid dose, opioids for anesthesia; paracetamol, NSAIDs and opioids as analgesia.
- Trial name
- NCT03663426
- Testing
- study group, control
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- AZ Sint-Jan AV
Cognitive Dysfunction, Opioid Free Anesthesia
Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries
In this study, the patients undergoing pituitary surgery in our clinic have examined in two groups. In the first group, anesthesia maintenance was provided with remifentanil and propofol infusion.
- Trial name
- NCT06793150
- Testing
- Remifentanil, dexmedetomidin
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kocaeli University
Opioid-free Anesthesia, Geriatric Population
Opioid-free Anesthesia and Quality of Recovery After General Anesthesia
This study aimed to evaluate the effect of an opioid-free anesthesia protocol on postoperative recovery quality in patients aged 65 years and older undergoing major surgery.
- Trial name
- NCT06846333
- Volunteers
- 60 people
- Sponsor
- Selcuk University
Thoracic Surgery, Analgesics, Opioid
Opioid Free Anesthesia in Thoracic Surgery
Proper assessment of pain and adequate analgesia in thoracic surgery is a challenging issue for medical practitioners. Basic aspects of thoracic anaesthesia are general anesthesia, intubation with double lumen tube and separation…
- Conditions
- Thoracic Surgery, Analgesics, Opioid, Anesthesia, Conduction
- Trial name
- NCT04355468
- Testing
- Opioid Anesthesia, Opioid Free Anaesthesia
- Where
- Poland
- Volunteers
- 66 people
- Sponsor
- Medical University of Silesia
PONV, Opioid Use
Opioid Free Versus Opioid Balanced Anesthesia
OPIOID FREE VERSUS OPIOID BALANCED ANAESTHESIA IN MIDDLE EAR SURGERY AIM OF THE WORK Primary aim: To compare between opioid and opioid free anaesthesia on post-operative nausea and vomiting in middle ear surgery Secondary aim…
- Trial name
- NCT03809949
- Testing
- Fentanyl Opioid anesthesia, Saline Nonopioid anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- University of Alexandria