Clinical trials: Opioid Use Disorders
Opioid Use Disorder
Adaptive Decision Support for Addiction Treatment Master
This study refines and optimizes the EMBED* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with…
- Trial name
- ADAPT (NCT06799117)
- Testing
- EMBED CDS, Nurse prompt to complete COWS, Provider Prompt
- Where
- 3 sites in United States
- Volunteers
- 1,912 people
- Sponsor
- Yale University
Opioid-Related Disorders
Informational App Development for mHealth for Patient Self-Management of Opioid Use Disorder
This study will evaluate the feasibility of an app that provides drug information to people in recovery from opioid use disorder. This study is designed to test the prototype app, not to determine health outcomes.
- Trial name
- KIOS-I (NCT05859035)
- Testing
- KIOS Informational App
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Biomedical Development Corporation
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Marijuana Use, Opioid Use
Reinforcing Effects of Marijuana and Opioids
The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for…
- Trial name
- NCT05485012
- Testing
- Marijuana, Opioid
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Opioid Abuse
AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm
The opioid epidemic is the largest man-made public health crisis the United States has faced. The objective of Trial 2 of the Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-2) study, is…
- Trial name
- AESOPS-2 (NCT04758637)
- Testing
- Overdose Notification
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Southern California
Opioid Use Disorder, Fentanyl
Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation
The goal of this pragmatic randomized controlled trial is to compare treatment outcomes of two strategies for initiating buprenorphine treatment (low-dose initiation and direct-to-inject) in adults with opioid use disorder (OUD)…
- Trial name
- COPILOT (NCT07469501)
- Testing
- Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Opioid Use Disorder
Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).
- Trial name
- NCT07158853
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Post Operative Pain Control, Narcotic Use
Sprix for Postoperative Pain Control Following Gynecologic Surgery
The ongoing opioid epidemic has altered both how physicians prescribe narcotics and patients' perceptions of those prescriptions.
- Conditions
- Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress
- Trial name
- NCT04444830
- Testing
- Sprix
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Oritavancin for Staphylococcus Aureus Infections in Opioid Users
This will be a pilot single-arm study consisting of 15 participants evaluating the use of oritavancin in the final consolidation phase (last two weeks of treatment) of systemic infections with Staphylococcus aureus (S.
- Trial name
- NCT03761953
- Testing
- Oritavancin Injection
- Where
- United States
- Sponsor
- University of Pennsylvania
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
The purpose of this study is to evaluate the relative impact a medical drug (methadone) or behavioral counseling program (Holistic Health Recovery Program) or both (methadone and Holistic Health Recovery Program) has on reducing…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- Harapan (NCT02396979)
- Testing
- Methadone, Holistic Health Recovery Program
- Volunteers
- 300 people
- Sponsor
- Yale University
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Substance Use Disorders, Prenatal Care
Routine Pregnancy Screening for Women on Opioid Substitution Therapy
Women who take opioid substitution therapy have higher rates of unintended pregnancy, more pregnancies, and a higher risk of pregnancy complications than the general population.
- Conditions
- Substance Use Disorders, Prenatal Care, Pregnancy Outcome
- Trial name
- PREG-O (NCT03489174)
- Testing
- Monthly Pregnancy Screening, Usual Care
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- McMaster University
Opioid Use Disorder, Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2
This study is stage 2, round 2 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of ED physicians following standard of care for the administration of…
- Trial name
- NCT07602218
- Testing
- Refined EMBED CDS, Provider alert to order consultation with addiction counselor
- Where
- 3 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
Heroin Dependence, Opioid Use Disorder
Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence
This research deals with behaviors that are part of opioid dependence. The purpose is to study how stress and medication dose can affect opioid drug use.
- Trial name
- BOS (NCT03015246)
- Testing
- Extended release morphine, Buprenorphine/Naloxone low dose, Buprenorphine/Naloxone moderate dose
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Wayne State University
Tobacco-flavored EC, Sweet-Cooling EC
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
- Conditions
- Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
- Trial name
- SWITCH (NCT07202039)
- Testing
- Brief individual counseling sessions
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Prisma Health-Upstate
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain, Postoperative, Opioid Use
Spinal Anesthesia and Peri-operative Opioid Consumption in Open Abdominal Prostatectomy
Retrospective analysis to assess the impact of spinal anesthesia on peri-operative opioid consumption during open abdominal prostatectomy.
- Conditions
- Pain, Postoperative, Opioid Use, Analgesia
- Trial name
- SAPOC (NCT03565705)
- Testing
- Open abdominal prostatectomy
- Where
- Germany
- Volunteers
- 636 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Pain, Depression
Digital Tools for Coping With Chronic Pain
Chronic pain is becoming increasingly more prevalent worldwide. High rates of co-morbid psychological distress are also commonly found among individuals living with chronic pain.
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- NCT03234439
- Testing
- myStrength
- Where
- 12 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- MyStrength, Inc.
Opioid Use, Opioid-use Disorder
Evaluating the Impact of the Bridge Clinic in Patients With Opioid Use Disorder
This study aims to determine whether referral to the Bridge Clinic reduces overall index hospital length of stay when compared to direct referral to a long-term outpatient addiction provider for patients with active opioid use…
- Trial name
- NCT04084392
- Testing
- Bridge Clinic, Usual Care
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- Vanderbilt University Medical Center
Opioid Use Disorder
KIOS Mobile App Evaluation
Evaluation of a mobile medical app (KIOS) vs. treatment as usual for the treatment of opioid use disorder (OUD).
- Trial name
- NCT06212557
- Testing
- KIOS App, KIOS App education, Treatment as usual
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio