Clinical trials: Opioid Use Disorders
Drug Overdose
Social Network Overdose Prevention and Education Intervention
The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators…
- Trial name
- NCT06327061
- Testing
- Network overdose prevention, Standard of care health education
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Opioid-use Disorder, Opioid-related Disorders
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
The RECOVER Study will examine clinical, environmental and socioeconomic factors in recovery from opioid use disorder (OUD) over a 24-month period following exit from a Phase III clinical program for a buprenorphine…
- Trial name
- RECOVER® (NCT03604861)
- Testing
- Not applicable - no defined intervention
- Where
- 35 sites in United States
- Volunteers
- 534 people
- Sponsor
- Indivior Inc.
Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
Cerebral Physiology of NOWS
This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the womb, compared to newborns who have not had any exposure.
- Conditions
- Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome, Opioid Use Disorder, Intrauterine Exposure
- Trial name
- NIRS for NOWS (NCT07610746)
- Testing
- FD-NIRS and DCS
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Achalasia
Post Operative Pain Control of POEM Procedure
Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for esophageal achalasia with a natural orifice transluminal endoscopic procedure and far less invasive than the standard surgical or laparoscopic Heller myotomy…
- Trial name
- NCT04177342
- Testing
- Fentanyl, Oxycodone
- Volunteers
- 196 people
- Sponsor
- Chen Wannan
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Opioid Use Disorder (OUD)
Mapping Ibogaine Neural Dynamics in Opioid Use Disorder
This study aims to understand how ibogaine treatment may change brain activity and symptoms in people with moderate-severe opioid use disorder (OUD), as defined by the DSM-5.
- Trial name
- MIND-OUD (NCT07226570)
- Testing
- Observational study with MRI/EEG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Opioid Use Disorder
Expanding Medication-Assisted Therapies in Central Asia
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the…
- Trial name
- ExMAT CA (NCT05579470)
- Testing
- NIATx
- Where
- 4 sites in United States, Kazakhstan and 2 more
- Volunteers
- 900 people
- Sponsor
- Yale University
Chronic Pain, Drug Dependence of Morphine Type
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal
The proposed clinical trial will address the problem of opioid withdrawal. Opioids are essential for pain-relief in the short term, but their continued use is associated with a host of adverse effects.
- Conditions
- Chronic Pain, Drug Dependence of Morphine Type, Symptom, Withdrawal
- Trial name
- NCT04939623
- Testing
- Probenecid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Persistent Post-surgical Pain, Acceptance and Commitment Therapy
Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT
A large number of veterans suffer from distress-based conditions, such as anxiety and depression, putting them at high risk of experiencing persistent pain and prolonged opioid use following surgery.
- Conditions
- Persistent Post-surgical Pain, Acceptance and Commitment Therapy, Substance Use Disorder
- Trial name
- PreACT (NCT02437188)
- Testing
- ACT (Acceptance and Commitment Therapy)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Barbara A Rakel
Substance Use Disorders (SUDs)
Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
Background: A Timeline Follow-Back (TLFB) is a tool that helps researchers track how much of a substance a person uses. Different versions of the tool are used to track the use of alcohol, cigarettes, and cannabis.
- Trial name
- NCT06995885
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Chronic Pain
Integrated Services for Pain: Interventions to Reduce Pain Effectively
Long-term pain -or pain that lasts for months or years-is one of the most common health problems in the United States. Clinicians often prescribe opioids which can help ease pain in the short term, but evidence does not support…
- Trial name
- INSPIRE (NCT03454555)
- Testing
- Shared Decision Making, Motivational Interviewing and Cognitive Behavioral Therapy for Chronic Pain
- Where
- 3 sites in United States
- Volunteers
- 543 people
- Sponsor
- RTI International
Heroin Abuse, Opioid Use Disorder
Neuroimaging and CBD for Opioid Use Disorder
The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone.
- Conditions
- Heroin Abuse, Opioid Use Disorder, Substance-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT04567784
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yasmin Hurd
Opioid-use Disorder, Substance Use Disorders
Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
This project will develop and test quality measures for and a facilitation model to help addictions treatment clinics increase use of medicines for opioid use disorders, retain clients longer in care, and help more people move…
- Trial name
- NCT04632238
- Testing
- Metrics-driven quality improvement (MDQI)
- Where
- 4 sites in United States
- Volunteers
- 7,950 people
- Sponsor
- NYU Langone Health
Opioid Use Disorder
Semaglutide for Helping Opioid Recovery
The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching…
- Trial name
- SHORE (NCT06639464)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital
Opioid-use Disorder
Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
The focus of this study is to examine the effectiveness of imFREE relative to mHealth ED in facilitating treatment retention and adherence and reducing opioid use among adults with OUD initiating BUP treatment.
- Trial name
- UCimFREE (NCT04808479)
- Testing
- imFREE mCBT, mHealth ED
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of California, Los Angeles
Chronic Pain, Pain, Musculoskeletal
Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment
This study will use multiple methods to assess the feasibility of conducting a fully powered multisite clinical trial to test the effectiveness of integrating mindfulness-based interventions into physical therapy for patients…
- Conditions
- Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
- Trial name
- PT-IN-MIND (NCT05875207)
- Testing
- Mindfulness based practice, Control/Standard Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pain, Postoperative, Opioid Use
Spinal Anesthesia and Peri-operative Opioid Consumption in Open Abdominal Prostatectomy
Retrospective analysis to assess the impact of spinal anesthesia on peri-operative opioid consumption during open abdominal prostatectomy.
- Conditions
- Pain, Postoperative, Opioid Use, Analgesia
- Trial name
- SAPOC (NCT03565705)
- Testing
- Open abdominal prostatectomy
- Where
- Germany
- Volunteers
- 636 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Opioid-use Disorder, Cocaine Use Disorder
Cariprazine for Comorbid Cocaine and Opioid Use Disorder
This is a phase IIa, randomized, placebo-controlled pilot study designed to examine whether low-dose cariprazine (1.5mg/d) impacts cocaine use in medically-stable OUD patients with co-occurring CocUD who have already been taking…
- Trial name
- NCT05063201
- Testing
- Cariprazine 1.5 MG
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kyle Kampman