Clinical trials: Opioid Use Disorders
Thoracic Diseases, Postoperative Pain
Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
The Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial is a single center, double-blind, randomized, active-comparator controlled clinical trial to assess the analgesic efficacy of intercostal nerve block by…
- Conditions
- Thoracic Diseases, Postoperative Pain, Opioid Use
- Trial name
- NCT03508830
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Arthropathy of Knee, Osteo Arthritis Knee
Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement
The main purpose of this study is to look at whether meditation techniques can help reduce pain and opioid use after surgery.
- Conditions
- Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation
- Trial name
- NCT05669066
- Testing
- Mindful meditation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Opioid Use Disorder, Staff
Methadone Patient Access to Collaborative Treatment
The trial of Methadone Patient Access to Collaborative Treatment (MPACT) will establish the impact of the intervention on patient outcomes of methadone treatment retention and in treatment overdose.
- Conditions
- Opioid Use Disorder, Staff, Patients
- Trial name
- MPACT (NCT06556602)
- Testing
- MPACT
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Opioid Use Disorder
Healthy Aging Through Movement
This study aims to examine the effectiveness of a supervised aerobic exercise program for persons with Opioid Use Disorder (OUD). Participants will be enrolled in a 12-week supervised aerobic exercise intervention.
- Trial name
- HELM (NCT05772884)
- Testing
- Supervised Exercise Intervention
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Opioid-use Disorder
Comparison of Naloxone Pharmacokinetics
Intranasal (IN) naloxone administration is an effective alternative to intravenous (IV) or intramuscular (IM) naloxone by emergency medical services for opioid overdoses and has been used successfully for this purpose as reported…
- Trial name
- NCT03386591
- Testing
- Naloxone, Mucosal atomization device and syringe, Narcan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Opioid Dependence With Current Use (Disorder)
Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement
There is growing recognition of the need for approaches to initiate treatment wherever patients touch the health care system, including the Emergency Department (ED).
- Trial name
- NCT05897788
- Testing
- Text Message Check-ins, Contingency Management
- Where
- United States
- Volunteers
- 1,808 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Use, Post-operative Pain
Opioid Use After Laparoscopic Salpingectomy
The purpose of this study is to evaluate patient-reported post-operative pain scores following minimally invasive tubal sterilization procedures to determine if a multimodal, non-opioid pain control regimen is non-inferior to a…
- Conditions
- Opioid Use, Post-operative Pain, Sterility, Female
- Trial name
- NCT06434233
- Testing
- Acetaminophen, Ibuprofen, Oxycodone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-use Disorder, Pregnancy Related
Perinatal Care and Medication Assisted Treatment: Carbon/Emery Counties
The purpose of this study is to enhance perinatal opioid use disorder (OUD) treatment in a rural setting by developing an evaluated curriculum of perinatal OUD provider education.
- Trial name
- NCT04448015
- Testing
- Perinatal Opioid Use Disorder Education and Enhanced Perinatal Care
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid-use Disorder, Opioid Withdrawal
Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
The objective of this study is to evaluate whether tAN via the tragus (vagal) and auriculotemporal (trigeminal) nerve pathways results in a clinically meaningful reduction in opioid withdrawal symptoms.
- Trial name
- NCT04731935
- Testing
- Sparrow Therapy System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Chronic Pain, Chronic Insomnia
NiteCAPP_HELPS_WD: Improving Sleep and Reducing Opioid Use in Chronic Pain Patients
This project addresses the highly significant problem of developing effective strategies for facilitating withdrawal from opioid medications.
- Conditions
- Chronic Pain, Chronic Insomnia, Opioid Use
- Trial name
- NCT05226026
- Testing
- NiteCAPP HELPS, Tapered Withdrawal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of MCAM in Healthy Adult Participants
The goal of this clinical trial is to test the safety and to see if there are any side effects of the investigational drug, MCAM. The main aim is to measure blood levels of the study drug after oral administration.
- Trial name
- NCT07602335
- Testing
- MCAM
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Arthropathy of Knee, Arthropathy of Hip
Does the Use of Intrathecal Morphine Increase the Length of Hospital Stay in Fast Track Orthopedic Procedures?
This is a clinical trial of intrathecal morphine for patients Patient with primary as well as revision knee and hip arthroplasty under regional anesthesia. This study would include a total of 134 patients.
- Trial name
- NCT05105074
- Testing
- Intrathecal Morphine
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Opioid Use Disorder
Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System
The research team is investigating Opioid Use Disorder (OUD), a disorder characterized by dysregulated dopaminergic tone, to evaluate the mechanisms of adjunctive treatment with calcitriol.
- Trial name
- NCT06261905
- Testing
- [11C]-PHNO, Calcitriol, PET Scan
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Bariatric Surgery Candidate, Pain, Postoperative
Efficacy of External Oblique Intercostal Block in Laparoscopic Bariatric Surgery
Laparoscopic bariatric procedures nowadays are employed under ERAS protocol as an ambulatory surgery. Pain after laparoscopic procedures arises significantly from port site incisions in the anterior abdominal wall, and shoulder…
- Conditions
- Bariatric Surgery Candidate, Pain, Postoperative, Narcotic Use, Analgesia
- Trial name
- NCT05592522
- Testing
- External oblique intercostal block, Oblique subcostal TAP block, Posterior Rectus sheath block
- Where
- Saudi Arabia
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Al Mashfa Medical Center
Pain, Postoperative, Obesity, Morbid
Effect of Bilateral Rectointercostal Fascial Plane Block on Postoperative Pain After Laparoscopic Sleeve Gastrectomy
This randomized controlled study aims to evaluate the effectiveness of the bilateral rectointercostal fascial plane (RIB) block for postoperative pain management in patients undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Pain, Postoperative, Obesity, Morbid, Laparoscopic Sleeve Gastrectomy (LSG), Opioid Use
- Trial name
- NCT07253610
- Testing
- Bilateral Rectointercostal Fascial Plane Block, Intravenous Patient-Controlled Analgesia (IV PCA) with Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samsun University
Opioid Use Disorder, Depressive Disorder
Ketamine for OUD and Comorbid Depression (OUDCD)
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge.
- Trial name
- NCT05051449
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore