Clinical trials: Opioid Use Disorder
Opioid Use Disorder, Cannabis Use
Cannabis Effects on Opioid Self-Administration
The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial.
- Trial name
- NCT07668635
- Testing
- Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shanna Babalonis, PhD
Substance Use Disorder (SUD), Opioid Use Disorders
Recovery Management Checkup Scalability and Sustainability Hybrid Experiment
Individuals who are involved in the criminal-legal system (CLS) are at high risk of drug-related overdose; they also face significant barriers to engaging in substance use disorder (SUD) treatment and recovery support services.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorders, Stimulant Overdose, Overdose Risk
- Trial name
- RMC-SS (NCT07873944)
- Testing
- Recovery Management Checkups (RMC) delivered by community-based agencies (RMC adopters), Recovery Management Checkups (RMC) delivered by staff under the research team (RMC by research staff)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Chestnut Health Systems
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT04587791
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Opioid Use Disorder, Mental Health Disorder
Supporting Treatment Access and Recovery in COD
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team…
- Trial name
- STAR-COD (NCT05138614)
- Testing
- Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Massachusetts, Worcester
Major Depressive Disorder, Opioid Use Disorder
Cortical rTMS as a Treatment for Depression
Depression is a leading cause of disability worldwide with a 19% lifetime prevalence in the United States. Dysfunctional reward processing is one of the core features of depression.
- Conditions
- Major Depressive Disorder, Opioid Use Disorder, Suicidality
- Trial name
- NCT05487911
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Opioid Use Disorder
Integrating MOUD in Nonmedical Community Settings (Better Together)
A multisite effectiveness-implementation study will be conducted in four sites to evaluate interventions to improve engagement and retention in MOUD with buprenorphine treatment persons with Opioid Use Disorder (OUD) in urban…
- Trial name
- NCT06416020
- Testing
- HC-MOUD Only, BT-MOUD with Buprenorphine
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Howard University
Opioid Use Disorder
Semaglutide for Helping Opioid Recovery
The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching…
- Trial name
- SHORE (NCT06639464)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital
Opiod Use Disorder
EEG Biomarkers for OUD: Diagnostic, Prognostic, and Predictive Applications
The US is suffering from a national opioid epidemic characterized by significant costs, overdoses, and deaths. Conventional Opioid Use Disorder (OUD) treatments (i.e., pharmacological and psychosocial interventions) are…
- Trial name
- NCT07085351
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Use Disorder, Opioid Withdrawal
Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder
IBO-CARE is a single-site Phase 1/2a study evaluating the safety, tolerability, feasibility and preliminary outcomes of medically supervised ibogaine with 12 months of recovery support in adults with moderate-to-severe opioid use…
- Conditions
- Opioid Use Disorder, Opioid Withdrawal, Substance Use Disorders
- Trial name
- IBO-CARE (NCT07871877)
- Testing
- Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, My-E-Health SENTINEL Digital Monitoring and Human-Gated Escalation Platform
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Clive Michelsen
Opioid Use Disorder, Sleep
The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
Opioid use disorder (OUD) is a chronic relapsing disorder and is well-known for its high-risk rate of overdoses and death. In OUD, sleep and circadian disruptions are highly prevalent, interfere with opioid maintenance treatment…
- Conditions
- Opioid Use Disorder, Sleep, Circadian Rhythms, fMRI Research
- Trial name
- NCT06832007
- Testing
- AYO light glasses (experimental), AYO light glasses (comparator)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Opiate-Related Disorders, Opiate Use Disorder
MedSMA℞T Mobile ED
The goal of this clinical trial is to learn if a new smartphone-based intervention can help with factors related to opioid misuse in parents and adolescent/early adult children.
- Conditions
- Opiate-Related Disorders, Opiate Use Disorder, Opioid
- Trial name
- NCT06848504
- Testing
- MedSMA℞T Mobile
- Where
- 3 sites in United States
- Volunteers
- 244 people
- Sponsor
- Olufunmilola Abraham
Opioid Use Disorder
Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic
This exploratory project will assess the acceptability and feasibility of monthly extended-release subcutaneous buprenorphine (BRIXADI; XR-B) to treat opioid use disorder (OUD) among persons in the community receiving care on a…
- Trial name
- NCT07176351
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Opioid Use Disorders, Cannabis Use
Cannabis and Opioid Use Disorder, Study 2
This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks.
- Trial name
- NCT07661446
- Testing
- Inhaled Cannabis, Intranasal Opioid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Kentucky
Opioid Use Disorder
Supporting Treatment for Opioids and Recovery Capital (STORC) - R61 Phase
We are studying whether training an identified support person and providing patient navigation (i.e. a peer recovery specialist assisting you with finding the right support) after delivery can increase "recovery capital"-the…
- Trial name
- STORC R61 (NCT07787039)
- Testing
- STORC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Friends Research Institute, Inc.
Opioid Use Disorder
Measurement Based Care in Opioid Treatment Programs
The goal of this HEAL Initiative study is to enhance the measurement, quality, and equity of care delivered in 20 community opioid treatment programs (OTPs) by creating and using measurement-based care (MBC) tools and systems.
- Trial name
- NCT06965010
- Testing
- Measurement-based care, Measurement As Usual
- Where
- United States
- Volunteers
- 3,650 people
- Sponsor
- University of Pittsburgh
Opioid Use Disorder
Towards Testing the Effectiveness of Recovery Community Centers (RCCs)
The goal of this pilot randomized clinical trial is to prepare for a larger randomized clinical trial (RCT) and collect some early data to learn if the intervention can help people who use medications for opioid use disorder…
- Trial name
- NCT07010978
- Testing
- Recovery Community Center Participation, Enhance Treatment as Usual
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Massachusetts General Hospital
Opiod Use Disorder
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System
This study, called the Chicago Data-driven Opioid use disorder Screening, Engagement, Treatment and Planning (C-DOSETaP) System, tests a new system of clinical care for patients with opioid use disorder (OUD) across a large…
- Trial name
- C-DOSETaP (NCT07498322)
- Testing
- OUD screening, MOUD, Continuity of care
- Where
- United States
- Volunteers
- 271,031 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Opioid Use Disorder
A Study of Brenipatide in Participants With Opioid Use Disorder
The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone.
- Trial name
- RENEW-Op-1 (NCT07420283)
- Testing
- Brenipatide, Buprenorphine
- Where
- 61 sites in United States, Canada and 2 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions
Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery
Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for…
- Conditions
- Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions, Orthopaedic Trauma, Orthopaedic Surgery
- Trial name
- MIRROR (NCT07486505)
- Testing
- Mindfulness Based Intervention, Educational Recording
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University