Clinical trials: Opiate Overdose
Opioid Overdose
Pharmacokinetic Evaluation of Intranasal Nalmefene Using Three Dosing Regimens
This study is to compare the pharmacokinetics (how the body absorbs, breaks down and eliminates drug from your body) of nalmefene when given as a single dose intranasally (IN;into the nose), as a single dose in each nostril and…
- Trial name
- NCT05219669
- Testing
- Nalmefene Hydrochloride
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Opiant Pharmaceuticals Inc
Overdose, Implementation as Usual
Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone)
The goal of this clinical trial is to compare the effectiveness of a multi-faceted implementation strategy, the Systems Analysis and Improvement Approach for Naloxone (SAIA-N), in syringe service programs (SSPs).
- Trial name
- SAIA-N (NCT05886712)
- Testing
- Naloxone, Usual intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- RTI International
Drug Overdose
Nasal Naloxone for Narcotic Overdose
The goal of this study is to determine if nasal naloxone is inferior to standard care for naloxone administration in a pre-hospital setting.
- Trial name
- NCT01912573
- Testing
- Intranasal (IN) naloxone, Intravenous (IV) naloxone, Intramuscular (IM) naloxone
- Where
- 3 sites in United States
- Volunteers
- 236 people
- Sponsor
- Judith Feinberg
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Opioid Overdose
European Cohort Study of the Effectiveness of Take Home Naloxone
This study aims to assess the effectiveness of take-home naloxone (THN) to reverse opioid overdose when administered by lay persons in a real world setting.
- Trial name
- NalPORS (NCT05072249)
- Testing
- Naloxone
- Where
- 6 sites in Denmark, Sweden and 1 more
- Volunteers
- 6,000 people
- Sponsor
- King's College London