Clinical trials: Opiate Overdose
Opioid-Use Disorder (OUD)
SafetyNet Program for Opioid Use Disorder (OUD)
The principal aim of this study is to determine whether a novel biopsychosocial intervention following opioid overdose (OD) affects 1) the frequency of secondary opioid OD events and 2) the proportion of individuals who remain…
- Trial name
- NCT04253782
- Testing
- Team Intervention
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Opioid Overdose (Trial 3 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT07875569
- Testing
- Opioid Overdose Prevention Training
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Opioid Overdose, Opiate Overdose
Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose
The goal of this clinical trial is to compare naloxone to nalmefene for the treatment of opioid overdose in adults. The main questions it aims to answer are: Does nalmefene lower the number of doses of medicine participants need…
- Trial name
- NCT06408714
- Testing
- Nalmefene Injection, Naloxone Injection
- Where
- United States
- Sponsor
- University of New Mexico
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Opioid Overdose
Opioids and Police Safety Study
Overdose deaths are currently the largest cause of accidental death in the US and opioid-related overdose deaths constitute the overwhelming majority of these deaths.
- Trial name
- OPS (NCT05008523)
- Testing
- Opioids and Police Safety Occupational Risk Reduction Training (OPS), Opioids and Police Safety Occupational Risk Reduction Training (COVID)
- Where
- United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- New York University
Opioid Use, Cognitive Change
Cognitive Functioning in Opioid Use Disorder
This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning.
- Conditions
- Opioid Use, Cognitive Change, Opioid-use Disorder
- Trial name
- NCT05001789
- Testing
- CogMed
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Overdose
An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses
The purpose of this study is to pilot and implement a peer mentor intervention focused on overdose prevention and care. The intervention consists of 3 sessions.
- Trial name
- NCT04212364
- Testing
- Peer Education, Narcan Nasal Product
- Where
- United States
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Morphinan Opioid Overdose
Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
- Trial name
- NCT01293058
- Testing
- Intranasal naloxone, Intravenous
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Pain, Drug Overdose
Primary Care Intervention to Reduce Prescription Opioid Overdoses
The high rate of adverse events, including overdose, resulting from opioid pain medication use threatens the quality and safety of pain care in the Veterans Health Administration (VHA) and elsewhere and is a critical public…
- Conditions
- Pain, Drug Overdose, Opioid Use Disorders
- Trial name
- POST (NCT02464410)
- Testing
- Motivational intervention, Psycho-educational control, Long-term opioid therapy informed consent
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- VA Office of Research and Development
Opioid Overdose, Opioid-use Disorder
User Acceptability of a Device-Based Opioid Overdose Intervention
This pilot study evaluates the needs of opioid users for a device-based intervention for opioid overdoses. The results of this one-time short questionnaire will inform development of a novel naloxone delivery device.
- Conditions
- Opioid Overdose, Opioid-use Disorder, Substance Use Disorders
- Trial name
- NCT04530591
- Testing
- Survey, Interview
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Pennsylvania
Opioid-Use Disorder, Opioid Overdose
Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose
This pilot study will evaluate the feasibility and clinical utility of extended-release injectable buprenorphine (XR-BUP) for the treatment of opioid use disorder (OUD) among individuals at high-risk for overdose (OD).
- Trial name
- FASTER-BUP (NCT04815590)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- BC Centre on Substance Use
Opioid Overdose
Naloxone Nasal Spray Pharmacokinetic Study
This study aims to compare the pharmacokinetics of naloxone when administered as the Mitovie nasal spray (Test Product) and as a solution for injection (Comparator Product) administered intranasally using a mucosal atomization…
- Trial name
- NCT01622504
- Testing
- MVP005, Naloxone hydrochloride solution for injection with mucosal atomization device
- Where
- Jordan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mitovie Pharma Ltd
Opioid Overdose
Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program
The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has implemented Relay, a novel program that engages and intervenes with individuals in the ED following an opioid OD and for the next 90 days, with the goal…
- Trial name
- NCT04317053
- Testing
- RELAY
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- NYU Langone Health
Substance-Related Disorders
Benzodiazepines in Opiate Replacement Therapy
Drug-related deaths (DRD) are a significant and increasing public health problem in Scotland. Benzodiazepines and BZD-type substances (BZD) are increasingly implicated in DRD.
- Trial name
- BENZORT (NCT04622995)
- Testing
- Benzodiazepine
- Where
- United Kingdom
- Volunteers
- 46,899 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Opioid Overdose
Blood Naloxone Levels Following Intradermal Injection in Humans
The main purpose of this study is to evaluate pharmacokinetics/pharmacodynamics of intradermal administration of naloxone in healthy adult subjects.
- Trial name
- NCT05876572
- Testing
- intradermal naloxone, microneedle injection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Substance Use, Mental Health Issue
Community Driven Substance Use Recovery for High Opioid Overdose Areas
The main goal of this current study is to develop and optimize methods for increasing access to, uptake of, and engagement in MAT (Medication Assisted Treatment) among communities of color.
- Conditions
- Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
- Trial name
- IMANI U (NCT05260047)
- Testing
- IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage
- Where
- 8 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Overdose, Opioid Use
Machine-Learning Prediction and Reducing Overdoses With EHR Nudges
The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction…
- Conditions
- Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
- Trial name
- mPROVEN (NCT06806163)
- Testing
- EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care
- Where
- United States
- Volunteers
- 1,350 people
- Sponsor
- University of Pittsburgh
Opioid Overdose
Improving Availability of Intranasal Naloxone
While there is a lifesaving medication called naloxone that can reverse the deadly effects of opioid overdose, patients often fail to fill the prescription at the pharmacy when it is prescribed.
- Trial name
- NCT05877118
- Testing
- Enhanced Overdose Education (EOE), Standard education
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Hartford Hospital
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD