Clinical trials: Opiate Dependence
Opioid-Related Disorders
Neurobiology of Opioid Dependence: 4 - 4
The purpose of this study is to determine the effect of chronic naltrexone pre-treatment on the response to yohimbine in healthy volunteers.
- Trial name
- NCT00000195
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- Yale University
Chronic Pain
Effectiveness of Buprenorphine/Naloxone
Long-term use of opioids for chronic pain is a growing health and social problem, mainly because of the risk of dependence. Buprenorphine/naloxone is used as substitution therapy for opioid dependence.
- Trial name
- NCT02882412
- Testing
- observational
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Opioid Dependence
Using mHealth to Aid Opioid Medication Adherence Pilot Study
The purpose of this study is to evaluate the usability of an interactive smartphone application (app) designed to engage and support patients receiving bup/nal.
- Trial name
- NCT02017041
- Testing
- Medsignals, smartphone app
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Care Team Solutions
Opiate Dependence, HIV Infections
Integrating Buprenorphine Into HIV Treatment
We hypothesize that integrating drug treatment into HIV treatment will improve HIV outcomes as well as drug treatment outcomes in heroin users. This study will test this hypothesis by randomizing patients to two groups.
- Trial name
- NCT00241930
- Testing
- Integrating drug treatment into HIV services
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Organization to Achieve Solutions in Substance Abuse (OASIS)
Opioid Dependence
A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist Hydromorphone
This study adopted a randomized, double-blind study design to evaluate the antagonistic effect, safety and pharmacokinetics of Naltrexone (opioid receptor antagonist) implantation after Hydromorphone (opioid receptor agonist)…
- Trial name
- NCT07014644
- Testing
- 1.5g Naltrexone Implant
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Shenzhen Sciencare Medical Industries Co., Ltd.
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Opioid Use Disorder, Major Depressive Disorder (MDD)
Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
This study will compare transcranial magnetic stimulation (TMS) with sham TMS in people with opioid use disorder who are taking buprenorphine and have major depressive disorder with ongoing depressive symptoms.
- Trial name
- NCT07842601
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kentucky
Hyperalgesia, Opioid-Related Disorders
Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia
Individuals who reduce or stop use of opioid medications are at risk for developing hyperalgesia, which is an increased sensitivity to pain.
- Trial name
- NCT00218374
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, Substance-related Disorders
Prescription Opioid Addiction Treatment Study (POATS)
The purpose of this study is to determine whether treatment outcome for subjects dependent on prescription opioid analgesics can be improved by adding individual drug counseling to the prescription of buprenorphine/naloxone with…
- Conditions
- Opiate Dependence, Substance-related Disorders, Opioid-related Disorders
- Trial name
- NCT00316277
- Testing
- Standard Medical Management (SMM) of Prescription Opiate Abuse, Enhanced Medical Management (EMM) of Prescription Opiate Abuse
- Where
- 12 sites in United States
- Volunteers
- 653 people
- Sponsor
- Mclean Hospital
Opioid Use, Opioid Dependence
Safe Return and Disposal of Unused Opioids
The opioid epidemic in the United States has become a clear health and safety concern for our children and families. Opioids given to our patients for the treatment of pain that go unused after the immediate post operative period…
- Conditions
- Opioid Use, Opioid Dependence, Opioid Abuse, Unspecified
- Trial name
- NCT03352479
- Testing
- Opioid Return
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Opioid Use, Opioid Dependence
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge
Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy.
- Conditions
- Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
- Trial name
- EQUIPPED (NCT05221866)
- Testing
- Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Opioid Use
Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
The primary aim of this study is to evaluate the administration of rectal acetaminophen to current and standard anesthesia and analgesia protocol in oocyte retrievals would reduce postoperative utilization of opioids (Tylenol…
- Trial name
- NCT03732469
- Testing
- Acetaminophen, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Cocaine Addiction, Opioid Addiction
sTMS for Substance Use-disordered Veterans
The purpose of this study is to determine if synchronized transcranial magnetic stimulation is safe and tolerable in individuals with cocaine, opioid, or alcohol use disorders.
- Conditions
- Cocaine Addiction, Opioid Addiction, Alcohol Addiction
- Trial name
- NCT04336293
- Testing
- sTMS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
HIV, Opioid Dependence
Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject Drugs
To improve ART initiation among people who inject drugs, the investigators propose to develop and pilot a multi-component Integrated Methadone and Antiretroviral Therapy strategy (IMAT) in Dar es Salaam, Tanzania.
- Trial name
- IMAT (NCT02167425)
- Testing
- IMAT
- Volunteers
- 800 people
- Sponsor
- Pangaea Global AIDS Foundation
Opioid Dependence, Substance-Related Disorders
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
The purpose of this study is the safety and efficacy of Buprenorphine/Naloxone in the treatment of opioid dependence. A compassionate use study.
- Trial name
- NCT00015340
- Testing
- Buprenorphine/naloxone
- Where
- 5 sites in United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Opioid Abuse or Dependence
CEDRN: Opioid Registry
Unregulated opioids remain a leading driver of preventable mortality and potential years of life lost in Canada. Emergency departments (EDs)-open 24/7 and frequently accessed by people who use drugs-offer critical opportunities…
- Conditions
- Opioid Use Disorder, Opioid Abuse or Dependence, Opioid Withdrawal, Polysubstance Drug Use (Indiscriminate Drug Use)
- Trial name
- CEDRN OUD (NCT07466784)
- Where
- Canada
- Volunteers
- 7,200 people
- Sponsor
- University of British Columbia
Opioid Abuse, Opioid Addiction
The Discriminative Effects of Tramadol in Humans
This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram.
- Conditions
- Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
- Trial name
- NCT00499746
- Testing
- tramadol, Hydromorphone, Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Chronic Pain, Opioid Use
Cognitive Function and Addiction Under Opioid Tapering
This study evaluates the effects of opioid dose reduction in the treatment of chronic pain in adults. Participants were divided in two groups: 1) patients that reduced opioid dose and 2) patients that kept the same opioid dose…
- Trial name
- NCT03365817
- Testing
- Opioids taper off, Opioid stable treatment
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Opioid Dependency
Re-Treatment Study of Probuphine in Opioid Addiction
Probuphine (buprenorphine implant) is an investigational implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence.
- Trial name
- NCT01262261
- Testing
- Probuphine (buprenorphine implant)
- Where
- 18 sites in United States
- Volunteers
- 85 people
- Sponsor
- Titan Pharmaceuticals