Clinical trials: Open-label
Peripheral Neuropathy Pain
PK and Food Effect of Pregabalin Study After Dosing in Healthy Male Volunteers
This study is to assess the pharmacokinetics of Pregabalin controlled release formulation after multiple dosing as compared to Pregabalin immediate release formulation and the food effect of high fat diet after single dosing in…
- Trial name
- NCT02783638
- Testing
- YHD1119, Lyrica
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Drug Interaction
A Drug-Drug Interaction Study Between ATI-2173 and Tenofovir Disoproxil Fumarate in Healthy Subjects
This study is a single-center, open-label, 2-cohort, multiple dose, fixed-sequence, DDI study in healthy adult subjects. Healthy volunteers will be administered multiple oral doses of ATI-2173 in combination with tenofovir…
- Trial name
- NCT05137548
- Testing
- ATI-2173 50 mg, Tenofovir 300Mg Oral Tablet
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Antios Therapeutics, Inc
Healthy
Study to Evaluate the Pharmacokinetic Characteristics and Safety of IN-C004 in Healthy Volunteers
To evaluate the pharmacokinetic characteristics and safety of IN-C004 in healthy volunteers
- Trial name
- NCT04654078
- Testing
- IN-C004 with water, IN-C004 without water, K-CAB tab. with water
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Healthy
A Comparative Study to Evaluate Two Air-Activated Adhesive Backed Heat Patches
A disposable, air-activated, adhesive backed heat patch is being evaluated. Study terminated -O subjects.
- Trial name
- NCT02080143
- Testing
- Thermal Adhesion Patch
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Healthy
GLS-5700 in Dengue Virus-Naïve Adults
The clinical trial will assess the safety, tolerability, and immunogenicity of GLS-5700. GLS-5700 is a synthetic DNA plasmid vaccine against the Zika virus.
- Trial name
- NCT02809443
- Testing
- GLS-5700
- Where
- 3 sites in United States, Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GeneOne Life Science, Inc.
Healthy Participants
A Study to Understand the Effect of Low-Fat and High-Fat Meals on the Medicine Called PF-07284890 in Healthy Adults
The purpose of the study is to evaluate the effect of a low-fat and high-fat meal on the medicine called PF-07284890 following three single doses PF-07284890.
- Trial name
- NCT05349864
- Testing
- PF-07284890 Treatment A, PF-07284890 Treatment B, PF-07284890 Treatment C
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Contraception
An Open-label Study to Evaluate Contraceptive Efficacy and Safety of the Transdermal Contraceptive System of Norelgestromine and Ethinyl Estradiol
The purpose of this study is to evaluate the contraceptive efficacy, safety, cycle control, compliance, and subject satisfaction of the transdermal contraceptive system, norelgestromine and ethinyl estradiol (NLGM / EE).
- Trial name
- NCT00307632
- Testing
- Norelgestromine (NLGM)/ethinyl estradiol (EE)
- Where
- 12 sites in Brazil, Mexico
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag Farmaceutica Ltda.
Formulation Bridging, Food Effect
A Formulation Bridging and Food Effect Study of PBI-200 in Healthy Volunteers
This is a single-dose, two-part, crossover formulation bridging and food effect study to assess the effect of formulation and food on the absorption and bioavailability of PBI-200 in normal, healthy volunteers.
- Trial name
- NCT05690932
- Testing
- PBI-200 Tablet, PBI-200 Capsule, PBI-200 Suspension
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pyramid Biosciences
Asthma, Chronic Obstructive Pulmonary Disease
Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy Volunteers
An open-label, single dose Pharmacokinetic (PK) comparability study to demonstrate comparable drug exposure following Subcutaneous benralizumab administration by using accessorized pre-filled syringe (APFS) or autoinjector (AI)…
- Trial name
- NCT02968914
- Testing
- Benralizumab
- Where
- 2 sites in Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Relative Bioavailability of Dabigatran and Digoxin in Healthy Male and Female Volunteers
To investigate the bioavailability of dabigatran with and without concomitant administration of digoxin and the bioavailability of digoxin with and without concomitant administration of dabigatran etexilate
- Trial name
- NCT02171052
- Testing
- Dabigatran etexilate, Digoxin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
A Study to Assess the Relative Bioavailability of JNJ-42756493 Tablets
The purpose of this study is to assess the relative bioavailability of 2 prototype G-025 tablets compared with the current G-018 tablet.
- Trial name
- NCT02466815
- Testing
- JNJ-42756493 Current Clinical Formulation (G-018), JNJ-42756493 Prototype Formulation I (G-025), JNJ-42756493 Prototype Formulation II (G-025)
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Severe Acute Respiratory Syndrome Coronavirus 2 Infection
A Strain Change Study for SARS-CoV-2 rS Vaccines
The present study aims to investigate the safety and immunogenicity of the Novavax JN.1 subvariant vaccine SARS-CoV-2 rS adjuvanted with Matrix-M (NVX CoV2705) in previously vaccinated adults.
- Trial name
- COVID-19 (NCT06409663)
- Testing
- NVX-CoV2705 Vaccine
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Novavax
Healthy
The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults
This is a drug interaction study to evaluate the PF-06751979 at steady state on the pharmacokinetics of oral midazolam single doses in fixed sequences including single dose midazolam alone in period 1 followed by multiple doses…
- Trial name
- NCT03126721
- Testing
- midazolam, PF-06751979
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteer
A Phase I PK Study of Balcinrenone/Dapagliflozin in Healthy Chinese Participants
This study is intended to evaluate the PK, safety, and tolerability of balcinrenone/dapagliflozin given as a single dose capsule to healthy Chinese participants.
- Trial name
- NCT06651021
- Testing
- balcinrenone/dapagliflozin
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Phase 1 Single Ascending Dose Study to Evaluate Safety, Tolerability and Pharmacokinetics of KBP-5074
This single ascending dose (SAD) study in healthy subjects will evaluate the safety, tolerability and pharmacokinetics of KBP-5074.
- Trial name
- NCT02228733
- Testing
- KBP-5074
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Follicular Lymphomas
ZR2 Versus R2 Regimen in the Treatment of Newly Diagnosed Follicular Lymphoma
Primary Objective: To compare the complete response rate (CR rate) after induction treatment between the ZR2 regimen and the R2 regimen.<br/><br/>Secondary Objectives: To compare the objective response rate (ORR) after induction…
- Trial name
- NCT07505849
- Testing
- Zanubrutinib+R2, R2
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KeshuZhou
Renal Impairment, Healthy Volunteers
A Study of TAK-279 in Adults With or Without Kidney Problems
The main aim of this study is to find out how the body processes 1 dose of TAK-279 (pharmacokinetics) in participants with kidney problems compared to participants without kidney problems.
- Trial name
- NCT05992155
- Testing
- TAK-279
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Takeda
Hypertension
Bioequivalence Study of Doxazosin 4 Mg Orally-Disintegrating Tablet With Or Without Water To Doxazosin 4 Mg Japanese Marketed Immediate Release Tablet Under Fasted Condition
To test bioequivalence of Doxazosin 4 Mg Orally-disintegrating Tablet with Or Without Water to Doxazosin 4 Mg Japanese Marketed Immediate Release Tablet Under Fasted Condition
- Trial name
- NCT01389609
- Testing
- Doxazosin 4 mg Japanese marketed IR tablet, Doxazosin 4 mg ODT with water, Doxazosin 4 mg ODT without water
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Eastern Equine Encephalitis
Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine
This study is being conducted to collect safety and immunogenicity data for the Eastern Equine Encephalitis (EEE) vaccine.
- Trial name
- NCT02654509
- Testing
- Eastern Equine Encephalitis Vaccine, Inactivated, Dried, TSI-GSD 104
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Healthy Volunteers
Comparison of Brivaracetam Oral Tablet (10 mg, 50 mg, 75 mg and 100 mg) and Brivaracetam Injection (100 mg) in Healthy Volunteers
To investigate the bioavailability/bioequivalence of Brivaracetam oral tablets (10 mg, 50 mg, 75 mg and 100 mg) and Brivaracetam intravenous injection (100 mg) in healthy volunteers.
- Trial name
- NCT01796899
- Testing
- Brivaracetam 10 mg oral tablet, Brivaracetam 50 mg oral tablet, Brivaracetam 75 mg oral tablet
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UCB Pharma SA
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