Clinical trials: Open-angle Glaucoma
Primary Open-angle Glaucoma, Glaucoma
Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma
The glycocalyx is a fibrillary lining structure that covers the inner surface of blood vessels. Composed of glycoproteins and polysaccharides, it is an essential determinant of vascular endothelial physiology: it limits…
- Trial name
- GLAUCALYX (NCT05264818)
- Testing
- Glycocheck, Ophthalmological examinations
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Glaucoma, Ocular Hypertension
This Follow-up Extension Study is Aimed to Monitor the Long-term IOP-lowering Performance/Efficacy and Safety of the MINT® Procedure in Open Angle Glaucoma Eyes.
This follow-up extension study is planned to invite all patients who underwent the MINT® surgery and completed Month 24 Visit in the prior MMS EEU-7 study.
- Conditions
- Glaucoma, Ocular Hypertension, Open-Angle Glaucoma
- Trial name
- NCT07081347
- Testing
- MINT Minimally Invasive Nasal Trabeculostomy
- Where
- Armenia
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Sanoculis Ltd
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Advanced Glycation End Products as a Biomarker for Accelerated Ageing
Globally primary open angle glaucoma (POAG) affects over 60 million people. The exact pathogenesis of POAG is poorly understood. A significant risk factor for glaucoma is advancing age.
- Conditions
- Primary Open Angle Glaucoma, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT02863224
- Where
- United Kingdom
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Anesthesia, Intraocular Pressure
Establishment of an Anaesthetic Protocol for Examinations for Children With Glaucoma or Suspected Glaucoma
Correct measurement of the intraocular pressure of children with glaucoma or suspected glaucoma is essential for diagnosis and therapy.
- Conditions
- Anesthesia, Intraocular Pressure, Glaucoma, Suspect, Pediatric Glaucoma
- Trial name
- eyeBIS (NCT03972852)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Glaucoma Open-Angle, Glaucoma Eye
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective (for patients operated and data recorded before 2018) and prospective (for data collected after 2018) in…
- Conditions
- Glaucoma Open-Angle, Glaucoma Eye, Glaucoma; Drugs, Glaucoma, Angle-Closure
- Trial name
- NCT04381611
- Where
- Switzerland
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dr. Kaweh Mansouri
Subject With Primary Open-angle Glaucoma (POAG)
A Prospective Evaluation of Open-Angle Glaucoma Subjects on Two Topical Hypotensive Medications Treated With One Suprachoroidal Stent
The purpose of this study is to assess the efficacy and safety of one iStent supra stent in the reduction of intraocular pressure associated with primary open-angle glaucoma.
- Trial name
- NCT01252914
- Testing
- iStent Supra Stent
- Where
- Armenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle, Healthy
Sensing Contact Lens-based Device for 24-hour Monitoring of Intraocular Pressure
Glaucoma is characterized by irreversible vision loss through the progressive death of optic nerve fibers unless timely diagnosis and adequate treatment are provided.
- Trial name
- NCT03689088
- Testing
- Goldfish, Tonometry
- Where
- Poland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sensimed AG
Glaucoma, Open-Angle
Feasibility Clinical Evaluation of the Calibreye System
To evaluate the safety and feasibility of the Calibreye System in patients with open angle glaucoma.
- Trial name
- NCT05885022
- Testing
- Calibreye System
- Where
- 4 sites in India, Mexico and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Myra Vision Inc.
Morbidity of Primary Open Angle Glaucoma
Matching Glaucoma With Impaired Cognition
Glaucoma is the leading cause of irreversible blindness in the world. The current study is designed to find the underlying relationship between impairment of topological perception and incidence of glaucoma.
- Trial name
- MAGIC (NCT03695224)
- Testing
- Topological perception test
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Open Angle Glaucoma
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
The purpose of this study is to evaluate the effectiveness of a new laser (called Micropulse Laser Trabeculoplasty or MLT) in the treatment of glaucoma compared to the conventional laser presently used which is called selective…
- Trial name
- NCT01956942
- Testing
- Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- David Belyea
Primary Open-angle Glaucoma
Effects of Primary Open-angle Glaucoma on Visual-motor Coordination
Commonly used visual function assessments in glaucoma diagnosis and treatment-such as visual acuity, visual field, and contrast sensitivity-do not directly capture the impact of the disease on patients' daily abilities.
- Trial name
- NCT06692205
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma Open-Angle
Social History and Glaucoma Progression
The objective of this study is to predict of glaucoma progression. By imaging of the retinal nerve fiber layer RNFL, optic nerve head (ONH) and macular measurements using spectral-domain OCT (SD-OCT) instruments
- Trial name
- OCT (NCT06434155)
- Where
- Egypt
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Assiut University
Primary Open Angle Glaucoma
Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT04396002
- Testing
- Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Malay Glaucoma Eye Study II Navigation, Mobility and Reading Ability in Primary Glaucoma
With the improvement of health system, the life span of Asians has increased tremendously especially in Malaysia. As an early preparation to be an 'aging country' in 2023, Malaysia needs to prepare infrastructure and policy to…
- Trial name
- MaGESII (NCT04736264)
- Testing
- Visual rehabilitation module: navigation and mobility, Visual rehabilitation module: exercise, Visual rehabilitation module: reading
- Where
- Malaysia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Effect of Drug
Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.
It is a randomised, double-blinded clinical trial in which consenting participants who meet the inclusion criteria would be randomised into 2 groups.
- Trial name
- NCT05606796
- Testing
- Latanoprost 0.005% Ophthalmic Solution
- Where
- Nigeria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uzoma Chinyei Joan
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH
Cataract, Primary Open-angle Glaucoma
Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
- Trial name
- NCT03889652
- Testing
- Oct scans
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Glaucoma, Open-Angle, Eye Diseases
The Flashing Light-Induced Pupil Response (FLIPR) Glaucoma Study
This study is designed to investigate whether the pupil response to slowly flashing colored lights is significantly altered in patients with glaucoma, as compared to a control group of subjects without glaucoma.
- Trial name
- FLIPR (NCT01857440)
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ohio State University
POAG, Primary Open Angle Glaucoma
A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma
The purpose of the study is to provide evidence that the efficacy of Xalatan will be superior to Apo-latanoprost and Co-latanoprost in the reduction of intraocular pressure in patients with primary open angle glaucoma.
- Conditions
- POAG, Primary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT02792803
- Testing
- Xalatan, Apo-Latanoprost, Co-Latanoprost
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. David Yan
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki