Clinical trials: Open Surgery
Chronic Periodontitis With Infra-bony Defects
Effect of Hyaluronic Acid in the Treatment of Periodontal Pockets
The aim of this study is to evaluate the effect of hyaluronic acid in the surgical treatment of periodontal pockets in people with gum disease. This research consists of clinical and radiographic studies.
- Trial name
- NCT02170857
- Testing
- Hyaluronic Acid
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Renal Cancer, Partial Nephrectomy
Complications Associated With Partial Nephrectomy for Renal Cancer
This paper evaluates the initial complications and the complications two years postoperatively necessitating re-hospitalisation for three surgical procedures for renal tumour partial nephrectomy .
- Trial name
- NCT05168761
- Testing
- partial nephrectomy
- Volunteers
- 7,664 people
- Sponsor
- Central Hospital, Nancy, France
Carpal Tunnel Syndrome
Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release
The use of electrocautery for surgical skin incision in general surgery is known to decrease post-operative pain. This study compares the use of scalpel and electrocautery for surgical skin incision in open carpal tunnel release…
- Trial name
- OCTR-Electro (NCT02791529)
- Testing
- Electrocautery, Scalpel
- Volunteers
- 16 people
- Sponsor
- Turku University Hospital
Cirrhosis, Liver
Rotational Thromboelastometry Guided Blood Component Use in Children With Cirrhosis Undergoing Invasive Procedures: A Randomized Controlled Trial
Blood products are commonly used before invasive procedures in patients with end-stage liver diseases despite cirrhosis being a thrombophilic state.
- Trial name
- NCT04460222
- Testing
- Rotational Thromboelastometry to guide blood product transfusion pre invasive procedure, Conventional transfusion methods to guide blood product transfusion pre invasive procedure
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Primary Hyperparathyroidism
Evaluation of Non Specific Symptoms and Quality of Life Before and After Surgery for Mild Primary Hyperparathyroidism
The purpose of this study is to evaluate the evolution of the non specific symptoms for 116 patients with mild primary hyperparathyroidism before and 3, 6 and 12 months after surgery.
- Trial name
- NCT01776502
- Where
- 4 sites in France
- Volunteers
- 116 people
- Sponsor
- Nantes University Hospital
Gastroesophageal Reflux
Esomeprazole (NEXIUM) vs. Surgery
The study investigates the efficacy of long-term treatment of esomeprazole compared to anti-reflux surgery in the control of gastroesophageal reflux disease by assessing time to treatment failure.
- Trial name
- LOTUS (NCT00251927)
- Testing
- esomeprazole, Laparoscopic fundoplication (surgery)
- Where
- 59 sites in Austria, Belgium and 10 more
- Volunteers
- 626 people
- Sponsor
- AstraZeneca
Laparotomy, Incisional Hernia
Clinical Performance and Safety of Suture-TOOL
The goal of this single arm intervention study is to investigate the safety and performance of a suturing device for closure of the midline incision after open abdominal surgery.
- Conditions
- Laparotomy, Incisional Hernia, Wound Infection, Closure Technique
- Trial name
- NCT05695157
- Testing
- Suture-TOOL
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Suturion AB
Surgical Acute Wounds
Comparison of Efficacy on Healing, and Safety of Two Dressings Urgotul and TulleGras MS on Surgical Acute Wounds.
Evaluation of non-inferiority on healing rates of two dressings Urgotul and TulleGras MS in the treatment of surgical acute wounds.
- Trial name
- NCT02322710
- Testing
- Urgotul: Low-adherent dressing, TulleGras M.S.: Vaseline gauze
- Where
- 33 sites in France
- Volunteers
- 208 people
- Sponsor
- Mylan Inc.
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Nipple-sparing Mastectomy, Immediate Prosthesis Reconstruction
Endoscopic and Robotic NSM with Immediate Prosthesis Breast Reconstruction
Breast cancer is the most common malignant tumor in women. Surgical treatment is the most important treatment for early breast cancer. Breast cancer resection is considered to be a destructive operation.
- Conditions
- Nipple-sparing Mastectomy, Immediate Prosthesis Reconstruction, Endoscopic Surgery, Robotic Surgery
- Trial name
- EnRoNSM (NCT06748677)
- Where
- China
- Volunteers
- 484 people
- Sponsor
- Peking University People's Hospital
Perianal Fistula, Crohn Disease
Fistulodesis Pilot Study for Closure of Perianal Fistulae
In this pilot study a new surgical treatment approach for perianal fistulae, called Fistulodesis, is performed. The study aims to assess effectiveness, safety and tolerability of the Fistulodesis procedure.
- Trial name
- NCT03322488
- Testing
- Fistulodesis
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
HIV
Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
The World Health Organization and UNAIDS cite that male circumcision can reduce the lifetime risk of HIV infection by 60% in high risk areas such as Sub Saharan Africa.
- Trial name
- NCT01284088
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Rwanda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Cholecystectomy, Hernia, Abdominal
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
The goal of this study is to identify the genes as well as their association with Nalbuphine. This will help the investigator to identify opioid vulnerability in Pakistani population in the postoperative patients and will…
- Conditions
- Cholecystectomy, Hernia, Abdominal, Appendectomy, Open Colorectal Surgery
- Trial name
- Nal (NCT06996561)
- Testing
- Nalbuphine Injection, Next Generation Sequencing, whole exome sequencing
- Where
- Pakistan
- Volunteers
- 263 people
- Sponsor
- Dr. Asma Abdus Salam
Ankle Fractures, Surgery
Immediate Weight-Bearing Ankle Study
This single-centre historical control group comparative study will compare outcomes of surgically-treated rotational ankle fractures and the current routine practice of early protected weightbearing and range of motion with…
- Trial name
- NCT03032653
- Testing
- Late Rehabilitation, Early Rehabilitation
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Fraser Orthopaedic Research Society
Lumbar Spine Degeneration
Study Using the SpinalStim Device Following Lumbar Fusion Surgery
This study examines the effect of adjunctive use of the SpinalStim bone growth stimulator on lumbar fusion rate in high risk subjects who have had lumbar fusion surgery.
- Trial name
- NCT03176303
- Testing
- SpinalStim
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Orthofix Inc.
Infra and Juxtarenal Abdominal Aortic Aneurysms
Laparoscopic Versus Open Abdominal Aortic Aneurysm (AAA) Exclusion
In many countries the gold standard for treating abdominal aortic aneurysms is still open surgery with a long incision. In patients with suitable anatomy alternatively an endovascular approach can be chosen.
- Trial name
- LapAorta (NCT00821145)
- Testing
- conventional surgery, laparoscopic AAA resection, laparoscopic stapler anastomosis
- Sponsor
- Augusta Hospital Duesseldorf
Colon Tumor
Right-sided Colon Tumor, Laparoscopic Versus Open Surgery, in an ERAS Protocol
Register study. Patients who had been operated for right-sided colon tumor or benign adenoids between year 2011 to 2012. The study compare open surgery with laparoscopic surgery in an ERAS (Enhanced Recovery After Surgery)…
- Trial name
- NCT01831245
- Where
- 3 sites in Sweden
- Volunteers
- 125 people
- Sponsor
- Karolinska Institutet
Rectal Cancer Surgery, Middle and Low Rectal Cancer
Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer Surgery
The goal of this clinical trial is to determine whether closing the pelvic floor peritoneum during laparoscopic radical resection of mid-low rectal cancer can reduce the incidence of postoperative ileus.
- Conditions
- Rectal Cancer Surgery, Middle and Low Rectal Cancer, Intestinal Obstruction, Ileus
- Trial name
- TOWER-1 (NCT07432542)
- Testing
- Pelvic floor peritoneum reconstruction
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Sun Yat-sen University
Cancer, Pain
Study of the Efficacy of Kalinox® 170 Bar in Adult Oncology
In the oncology practice, The National Union of the Centres of Fight Against the Cancer recently published the Standards, Options and Recommendations for the coverage of the pains provoked during the invasive gestures of a short…
- Trial name
- NCT00646945
- Testing
- 50% Oxygen/50% Nitrous oxide premix (Kalinox 170 bar), 50% Oxygen/50% Nitrogen premix
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Air Liquide Santé International
Shoulder Pain
A Study Comparing Two Methods of Placing an Interscalene Nerve Catheter for Postoperative Pain Control in Patients Who Undergo Open Shoulder Surgery.
This is a randomized, double-blinded, prospective study designed to compare two approaches (in the plane of the ultrasound beam and out of the plane of the ultrasound beam) to placing an interscalene nerve block and catheter for…
- Trial name
- NCT01696188
- Testing
- interscalene nerve catheter
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Thomas Jefferson University