Clinical trials: Open Surgery
Esophageal Cancer, Gastric Cancer
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
Cancer of the food pipe (oesophagus) and stomach are increasingly common. Currently, most patients with cancer of the oesophagus and stomach are treated with surgery with or without additional chemotherapy or radiotherapy.
- Trial name
- SARONG-II (NCT06115629)
- Testing
- Surveillance protocol
- Where
- 13 sites in Germany, Ireland and 3 more
- Volunteers
- 952 people
- Sponsor
- University of Dublin, Trinity College
Non Palpable Cervical Lesions Suspicious for Metastasis
Ultrasound-Guided Hook-Wire Localization for Excision of Non-palpable Cervical Lesions Suspicious for Metastasis
The goal of this randomized controlled trial is to determine whether ultrasound-guided hook-wire localization improves surgical efficiency and accuracy compared with ultrasound-guided surgery alone for the excision of…
- Trial name
- NCT07672912
- Testing
- Ultrasound-guided hook-wire localization, Ultrasound-guided surgical excision alone
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Rusana Bark
Melanoma
A Study To Assess The Safety Of Administering CP-675,206 As A One Hour Infusion In Patients With Surgically Incurable Advanced Melanoma
This will show if CP-675,206 can be administered safely as an intravenous infusion lasting one hour. CP 675,206 already has been administered to 835 subjects over 1.0 - 7.5 hours.
- Trial name
- NCT00585000
- Testing
- CP-675,206
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- AstraZeneca
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Chronic Thromboembolic Pulmonary Hypertension
A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery and/or Interventional Treatment
Selexipag is available in many countries for the treatment of pulmonary arterial hypertension (PAH). Due to the similarities between PAH and chronic thromboembolic pulmonary hypertension (CTEPH) and the observed efficacy of other…
- Trial name
- SELECT (NCT03689244)
- Testing
- Selexipag
- Where
- 162 sites in United States, Argentina and 29 more
- Volunteers
- 128 people
- Sponsor
- Actelion
Systemic Inflammatory Response Syndrome
Immunophenotyping of Patients With Postoperative SIRS
The purpose of this study is to develop an immune-phenotype based prediction of postoperative SIRS in patients undergoing open heart surgery.
- Trial name
- NCT02957175
- Testing
- Immunophenotyping
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Coronary Artery Disease
Multicentre Radial Artery Patency Study: Results of Patency Beyond 5 Years After Coronary Artery Bypass Surgery
Bypass surgery is often required to treat severe coronary heart disease. Either arteries or veins can be used as bypass grafts. We wish to compare the long-term durability of the saphenous vein from the leg to that of the radial…
- Trial name
- RAPS - 5 years (NCT00187356)
- Testing
- Radial Artery and Saphenous Vein Grafts Randomized to either right coronary or left circumflex coronary artery territories
- Where
- 13 sites in Canada, New Zealand
- Volunteers
- 269 people
- Sponsor
- Sunnybrook Health Sciences Centre
Surgery, Pneumonia
Multicenter Infection Surveillance Study Following Open Heart Surgery
The main goals of the study are as follows: (1) to determine the correlation between pain management using continuous infusion of local anesthetics and the incidence of pneumonia and surgical infection in cardiac surgery…
- Conditions
- Surgery, Pneumonia, Surgical Site Infection
- Trial name
- NCT00673712
- Testing
- Continuous Sternal Block, Opioid based analgesia
- Where
- 8 sites in United States
- Volunteers
- 647 people
- Sponsor
- Halyard Health
Spine Surgery
SpinePal Open Pilot
SpinePal is a self-guided digital intervention developed for patients undergoing spine surgery. The goal of this study is to learn if SpinePal is acceptable to people undergoing spine surgery.
- Trial name
- NCT07737912
- Testing
- SpinePal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Trustees of Dartmouth College
Intraocular Melanoma, Melanoma (Skin)
Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00025181
- Testing
- MART-1 antigen, gp100 antigen, incomplete Freund's adjuvant
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Southern California
Cardiac Surgery, Diuresis
Natriuresis-guided Depletion After Cardiac Surgery
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical.
- Conditions
- Cardiac Surgery, Diuresis, Congestion, Venous, Sodium Depletion
- Trial name
- EASY-CS (NCT07077772)
- Testing
- Furosemide intravenous titration based on natriuresis, Furosemide intravenous titration based on clinical examination
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pancreatic Adenocarcinoma Resectable, Non Metastatic
Evaluation of the Efficacy and Safety of Neoadjuvant Therapy in Patients With Surgically Resectable Pancreatic Adenocarcinoma.
This is an open master platform trial, which includes multi neo-adjuvant treatment trials, multi-center, national. This platform trial evaluates the major pathological response rate (mPR) after surgery.
- Conditions
- Pancreatic Adenocarcinoma Resectable, Non Metastatic, ECOG Performance Status Score of 0 or 1
- Trial name
- POWER (NCT07808567)
- Testing
- GnP, FOLFIRINOX
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Huge Hepatocellular Carcinoma (HCC) (≥10cm)
Safety and Efficacy of GSMs-TACE Combined With Surgical Resection in Treatment of Huge Hepatocellular Carcinoma (HCC) (≥10cm)
A Single center, Open, Randomized Controlled Trial Evaluating the Safety and Efficacy of GSMs-TACE combined with Surgical Resection in Treatment of Huge Hepatocellular Carcinoma (HCC) (≥10cm).
- Trial name
- NCT04619329
- Testing
- GSMs-TACE, Surgical Resection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Open Nephrectomy Surgery
Rhomboid Intercostal and Subserratus Plane Block Versus Quadratus Lumborum Block in Management of Postoperative Pain After Open Nephrectomy
Rhomboid intercostal block (RIB) and Rhomboid intercostal block with sub-serratus plane block (RISS) are the two types of plane blocks used for postoperative analgesia after abdominal surgeries.
- Trial name
- Nephrectomy (NCT06983249)
- Testing
- Rhomboid intercostal and Sub-serratus nerve block in nephrectomy, Quadratus lumborum nerve block in nephrectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Patients Undergoing Clean Surgery
OPSITE Post-Op Visible Wound Dressings in Treatment of Surgical Incisions
OPSITE Post-Op Visible is a tri-layer dressing made up of a low adherent wound contact layer, lattice shaped absorbent pad and a top film that is waterproof and a bacterial barrier and is coated with a water-based adhesive.
- Trial name
- OPOV (NCT01577225)
- Testing
- OPSITE POST-OP VISIBLE, Tape and Gauze
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- Smith & Nephew Medical (Shanghai) Ltd
Postoperative Pain, Hernia
A Safety and Efficacy Study of SABER®-Bupivacaine for Pain Following Hernia Repair
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Conditions
- Postoperative Pain, Hernia, Surgery
- Trial name
- NCT00974350
- Testing
- SABER-Bupivacaine
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 124 people
- Sponsor
- Durect
Confusion, Inflammation
Confusion in the Elderly After Colon Surgery
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
- Conditions
- Confusion, Inflammation, Acute Phase Reaction, Surgery
- Trial name
- NCT01623297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York Hospital Queens
Cancer of Cervix, Laparoscopic Surgery
Minimally Invasive Therapy Versus Open Radical Hysterectomy for Management of Early Stage Cervical Cancer
Radical hysterectomy and pelvic lymph node dissection (+/- aortic lymph node dissection) is the standard treatment for early stage cervical cancer.
- Trial name
- MITOR (NCT04999696)
- Testing
- radical hysterectomy
- Where
- Taiwan
- Volunteers
- 820 people
- Sponsor
- Chang Gung Memorial Hospital
Analgesia
ESP Versus PIFB for Analgesia in Open Cardiac Surgery: a Randomized Control Trial
This clinical trial compares analgesia efficiency and recovery outcomes between two different fascial plane block techniques (ESPB vs.PIFB) in cardiac surgery patients participant population/health conditions].
- Trial name
- NCT06322810
- Testing
- Erector spinae plane block (ESPB), Pecto-intercostal fascial plane blok (PIFB)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Chronic Pain
A Prospective Trial for the Effectiveness of the Use of Spinal Cord Stimulation (SCS) in Failed Knee Surgery
A study for patients who have chronic postoperative pain who had knee replacement surgery. If qualified, a 14 day trial and an implantation of spinal cord stimulator for control of pain will be administered.
- Trial name
- NCT01912924
- Testing
- Spinal cord stimulator (Boston Scientific)
- Where
- United States
- Sponsor
- Coastal Orthopedics & Sports Medicine