Clinical trials: Open Repair
Immune System
Safety and Pharmacokinetics of IMT504, an Immunomodulator and Tissue Repair Inducer
Phase 1 open-label dose-escalation study to evaluate the safety and pharmacokinetics of IMT504 Phosphorothioate Oligonucleotide, an immunomodulator and tissue repair inducer, in healthy volunteers.
- Trial name
- ECDA000/02 (NCT06312423)
- Testing
- Oligonucleotides, Phosphorothioate
- Where
- Argentina
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ministry of Public Health of the Province of La Rioja
Vaginal Atrophy
A Clinical Clinical Observation of CO2 Fractional Laser in Female Vaginal Repair
1. Vaginal atrophy is the most common indication in the treatment of vaginal rejuvenation. Its main manifestation is vaginal relaxation syndrome, which may be the early symptom of female pelvic floor dysfunction.
- Trial name
- NCT04492176
- Testing
- CO2 fractional laser（ACUPULSE,Lumenis）
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Post-Operative Pain
Transversus Abdominus Plane Catheters for Open Inguinal Hernia Repair
This study is designed to evaluate pain control of continuous transversus abdominis plane (TAP) blocks placed for open inguinal hernia repair.
- Trial name
- NCT02741492
- Testing
- Transversus Abdominis Plane Block
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Inguinal Hernia
Can Ideal Mesh Size be Standardized in Open Inguinal Hernia Repair
Two hundred consecutive unilateral inguinal hernia patients will be included in the study. Patients will be recorded by measuring the distance between the pubic tubercle and the deep inguinal ring, the distance between the…
- Trial name
- NCT04280094
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Perforated Peptic Ulcer
Open vs Laparoscopic Repair of Perforated Peptic Ulcer
comparison between outcomes of both open and laparoscopic repair of perforated peptic ulcer
- Trial name
- NCT05767320
- Testing
- open repair(exploration), abdominal laparoscopy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inguinal Hernia
Length of Hospital Stay in Laparoscopic Transabdominal Preperitoneal Vs. Open Mesh Repair in Inguinal Hernia: A Randomised Controlled Trial
To compare the mean length of hospital stay in laparoscopic trans abdominal preperitoneal repair versus open mesh repair in patients undergoing inguinal hernia repair with mesh.
- Trial name
- NCT05159232
- Testing
- hospital stay
- Where
- Pakistan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Memon Medical Institute
Tooth, Impacted, Wound Heal
Effect of Low Level Laser Therapy After Wisdom Tooth Removal
The aim is to test the effect of low level laser therapy on the relief of symptoms after wisdom tooth removal.
- Conditions
- Tooth, Impacted, Wound Heal, Quality of Life
- Trial name
- NCT04437316
- Testing
- Use of Low level Laser after wisdom tooth removal
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ventral Incisional Hernia
Open Complex Ventral Incisional Hernia Repair Using Biosynthetic Material for Midline Fascial Closure Reinforcement
Prospective, multicenter, observational study to evaluate performance of GORE® BIO-A® Tissue Reinforcement when used to reinforce midline fascial closure in single-staged open complex ventral incisional hernia repair.
- Trial name
- COBRA (NCT01325792)
- Testing
- GORE® BIO-A® Tissue Reinforcement
- Where
- 9 sites in United States, Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Incisional Hernia, Aortic Aneurysm
Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair
The goal of this retrospective observational study is to evaluate whether prophylactic mesh reinforcement during abdominal wall closure can prevent incisional hernias (IH) in patients undergoing open abdominal aortic aneurysm…
- Trial name
- NCT06762561
- Testing
- Prophylactic retromuscular mesh reinforcement
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hôpital Fribourgeois
Tendon Tear, Tendinopathy
Eendoscopic Versus Open Flexor Hallucis Longus Transfer in Managing Various Tendon Achilles Disorders
A well-established protocol for the treatment or augmentation a wide range of Achilles disorders including chronic Achilles tendon (AT) rupture, Achilles insertional tendinopathy, Haglund syndrome and among others, is a Flexor…
- Conditions
- Tendon Tear, Tendinopathy, Achilles Tendon Ruptures, Achilles Injuries Tendon
- Trial name
- NCT06639308
- Testing
- Endoscopic Flexor Hallucis longus tendon transfer to tendon achilles, Open Flexor Hallucis longus transfer to tendon achilles
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Foot Ulcers
Safety Study of Topical Human FGF-1 for Wound Healing
The purpose of the study is to see if FGF-1 is safe when applied topically to the surface of a wound.
- Trial name
- NCT00916292
- Testing
- FGF-1 141
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Phage Pharmaceuticals, Inc.
Periodontal Diseases
Application of L-PRF in Periodontal Surgery
The study will compare the clinical outcomes of the two procedures, open flap debridement (OFD) compared to open flap debridement with leukocyte and platelet-rich fibrin (L-PFR) as well as differences in patient postoperative…
- Trial name
- NCT06296498
- Testing
- Leukocyte Platelet-rich fibrin, Standard of care OFD
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
To Compare ILI/IHG Block to Wound Infiltration for Pain Relief After Hernia Repair
To Compare Ilioinguinal/Iliohypogastric Block to Wound Infiltration for Pain Relief After Hernia Repair in Adults
This study was conducted to assess the postoperative painscores in patients undergoing open inguinal hernia repair between two groups receiving either U/S guided ilioinguinal/iliohypogastric nerves block with Ropivacaine or wound…
- Trial name
- NCT04462510
- Testing
- Block/Local infiltration
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Wound Heal
Microlyte Dressing in the Management of Wounds
The purpose of this pilot study is to assess the efficacy of Microlyte Ag wound dressing when used in complex skin wounds. Microlyte Ag is a class-II medical device cleared by the FDA for prescription and over the counter use in…
- Trial name
- Microlyte (NCT03204851)
- Testing
- Wound Healing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mission Health System, Asheville, NC
Distal Radius Fracture
Opiate Sparing Protocol Randomized Controlled Trial in Open Distal Radius Fracture Repair
A comparison of oral morphine equivalents between an opiate sparing cohort and an opiate based cohort following open reduction internal fixation of a distal radius fracture.
- Trial name
- NCT05215236
- Testing
- Opiate Sparing, Opiate Based
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Shoulder Pain
Evaluating the Efficacy of PECS II Block Versus Axillary Ring Block in Rotator Cuff Repair Patients
Our current standard of care is to perform an interscalene peripheral nerve block for patients receiving rotator cuff repair surgery as it is an effective opioid-free alternative for post-operative pain control.
- Trial name
- NCT04930393
- Testing
- Nerve Block - either PECS II or axillary ring
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Abnormally Healing Wounds, Scars
Safety of Adipose-Derived Stem Cell Stromal Vascular Fraction
A single-arm, open-labeled, single-center, descriptive and exploratory safety trial using ADSC-SVF-002. ADSC-SVF-002 is an autologous adipose derived stem cell (ADSC)-containing stromal vascular fraction (SVF) obtained from…
- Conditions
- Abnormally Healing Wounds, Scars, Soft Tissue Defects
- Trial name
- NCT02590042
- Testing
- ADSC-SVF-002
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AdiSave Inc.
Hernia, Inguinal
Comparing Bi-level and Single-level ESP Block for Open Inguinal Hernia Repair
The goal of this clinical trial is to compare the effects of single-level and bi-level erector spinae plane block in open inguinal hernia repair surgery.
- Trial name
- NCT06155253
- Testing
- Erector spinae plane block
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
İnguinal Hernia
Quality of Life Effects of Laparoscopic and Open Surgery in Inguinal Hernia Treatment
Inguinal hernia is the most common type of hernia, presenting with swelling and pain in the groin area as clinical signs of abdominal wall hernias. The gold standard treatment for symptomatic inguinal hernias is surgery.
- Trial name
- NCT06988293
- Testing
- inguinal hernia repair
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Effect of Test Articles on the Healing of a Wound Artificially Induced by Liquid Nitrogen Spray
Study to Determine if Fibrin Affects the Ability of a Wound to Heal
The objective of this study is to evaluate the potential inhibitory effects of HP802-247 Vehicle on wound closure (healing), by comparing mean days to closure of superficial (partial-thickness) thermal wounds against similar…
- Trial name
- NCT01253135
- Testing
- Fibrin, White Petrolatum
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Healthpoint