Clinical trials: Open Nephrectomy
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nephrectomy, Lung Diseases
Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients
Patients with respiratory disease have an increased risk of developing complications perioperatively. The use of regional anesthesia decreases this risk with better postoperative outcome.
- Conditions
- Nephrectomy, Lung Diseases, Anesthesia
- Trial name
- NCT03324490
- Testing
- Thoracic Spinal Anesthesia, Thoracic Epidural Anesthesia, Bupivacaine 0.5% (hyperbaric)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nazmy Edward Seif
Post Operative Pain, Open Nephrectomy
Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy
Effective postoperative pain management following open nephrectomy remains a significant clinical challenge. Inadequate pain control after this procedure may lead to impaired respiratory function, delayed mobilization, prolonged…
- Trial name
- NCT07556536
- Testing
- Serratus Intercostal Plane Block, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Fayoum University Hospital
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Clear Cell RCC
Perioperative Trial With IO/TKI for Multi-stage Clear Cell Renal Cell Carcinoma
The IO/TKI regimens which combines Immune checkpoint inhibitors (IO) with Tyrosine Kinase Inhibitors (TKI) have become the standard first-line option for advanced ccRCC.
- Trial name
- TRIPLE-PATH (NCT07571551)
- Testing
- Toripalimab, Lenvatinib
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jinling Hospital, China
Pain, Postoperative, Postoperative Complications
Comparison of Quadratus Lumborum Block and Erector Spina Plane Block in Nephrectomy
Postoperative pain is important due to the limitation of physical functions, delay in recovery of quality of life, long-term opiate use, length of hospital stay, increased care costs and early postoperative pain trigger chronic…
- Trial name
- NCT04459624
- Testing
- Erector Spina Plane Block, Quadratus Lumborum Block 2
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Eskisehir Osmangazi University
Nephrectomy, Pain Scores
Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block
This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.
- Conditions
- Nephrectomy, Pain Scores, Paravertebral Block, External Oblique Intercostal Block
- Trial name
- NCT07071012
- Testing
- Bupivacaine, morphine, paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Hacettepe University
Nephrectomy, Prostatectomy
Safety and Performance Assessment of a First Four Arms on Demand Open Robotic Solution for Assisted PN, RN and RP
The purpose of this clinical investigation was to evaluate the safety and performance of the Bitrack System and its corresponding ElectroSurgical Endoscopic (ESE) instruments and Non-ElectroSurgical Endoscopic (NESE) instruments…
- Trial name
- NCT06119568
- Testing
- Robot assisted laparoscopic Radical/simple nephrectomy (RN), Partial nephrectomy (PN) or Radical Prostatectomy (RP).
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Rob Surgical Systems S.L.
Open Nephrectomy Surgery
Rhomboid Intercostal and Subserratus Plane Block Versus Quadratus Lumborum Block in Management of Postoperative Pain After Open Nephrectomy
Rhomboid intercostal block (RIB) and Rhomboid intercostal block with sub-serratus plane block (RISS) are the two types of plane blocks used for postoperative analgesia after abdominal surgeries.
- Trial name
- Nephrectomy (NCT06983249)
- Testing
- Rhomboid intercostal and Sub-serratus nerve block in nephrectomy, Quadratus lumborum nerve block in nephrectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Kidney Neoplasms
The Use of Self Retaining Sutures in Open and Laparoscopic Partial Nephrectomy
The objective of this study is to assess whether using a different type of suture (barbed sutures) during partial nephrectomy results in fewer postoperative complications than with traditional sutures (non-barbed).
- Trial name
- NCT01413607
- Testing
- Quill knotless tissue-closure device, 2-0 absorbable vicryl suture
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Ricardo Rendon
Postoperative Delirium (POD) After Nephrectomy
A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic Nephrectomy
A prospective comparative clinical trial of postoperative delirium incidence in open versus laparoscopic nephrectomy
- Trial name
- NCT07892898
- Testing
- Open Nephrectomy, Laparoscopic Nephrectomy
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Renal Cell Carcinoma
Comparison of Postoperative Analgesic Efficacy of the Erector Spina Plane Block and Quadratus Lumborum Block in Open Nephrectomy: a Prospective Randomized Clinical Study
patients who will undergo elective open nephrectomy will be divided into three groups; the control (PCA), the erector spina plane block, and the quadratus lumborum block.
- Trial name
- NCT05810571
- Testing
- preoperative remifentanil consumption, postopeartive controlled anlagesia with morphine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Pre- and Postoperative Analgesia, Spinal Anesthesia
Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma
The study aim to study whether spinal anesthesia (using: bupivacain, morfin och klonidin) can be better than epidural anesthesia during and after open surgery for renal cell carcinoma.
- Conditions
- Pre- and Postoperative Analgesia, Spinal Anesthesia, Renal Cell Carcinoma
- Trial name
- ASA (NCT02030717)
- Testing
- klonidin, epidural anesthesia
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Umeå University
Rhomboid Intercostal Block
Rhomboid Intercostal and Subserratus Plane (RISS) Block on Postoperative Painafter Open Nephrectomy Surgery
Rhomboid intercostal block (RIB) is a new interfascial plane block describe by Elsharkawy et al. in 2016. The region described is understood because the triangle of auscultation that's bounded medially by inferior a part of the…
- Trial name
- NCT05301075
- Testing
- Rhomboid Intercostal and Sub-Serratus block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Kidney Transplantation
Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation
This study will evaluate the differences between open surgical kidney donation and laparoscopic kidney donation on kidney donors and recipients.
- Trial name
- NCT00100516
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
the Patients With Partial Nephrectomy
Assessment of Acute Renal Injury During Partial Nephrectomy Using Neutrophil Gelatinase-associated Lipocalin (NGAL): Prospective Comparative Study Between Open, Video-assisted Minilaparotomy, Laparoscopic, and Robotic-assisted Laparoscopic Surgery
Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of acute kidney injury.
- Trial name
- NCT01891032
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Postoperative Pain Management
A Comparative Study Between Different Volumes During Erector Spinae Block for Pain Control
Since its first description by Forero et al. there have been many articles and case reports including an increasingly number of indications for the ESP block: chronic and acute pain treatment, rib fractures management in the…
- Trial name
- NCT04371341
- Testing
- erector spinae block by 0.25% bupivacaine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Renal Cell Carcinoma (Kidney Cancer)
Radical Nephrectomy With vs Without Template Lymph Node Dissection in High-Risk Renal Cell Carcinoma (T-LND RCC)
The goal of this clinical trial is to learn if a more thorough lymph node removal surgery, called "Template Lymph Node Dissection," can help prevent cancer from returning and help patients live longer, compared to removing only a…
- Trial name
- RECLND (NCT07321197)
- Testing
- Template Lymph Node Dissection, Selective Lymph Node Resection
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University Second Hospital
Renal Tumor
A Comparative Study Between Open and Robotic Partial Nephrectomy in Treatment of High Complex Renal Tumors.
To compare safety and efficacy between open and robotic partial nephrectomy in treatment of organ confined complex renal tumors (R.E.N.A.L score more than 7) as regarding surgical results, morbidity, clinical as well as…
- Trial name
- NCT04537247
- Testing
- partial nephrectomy for complex renal tumor
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Kidney Tumors, CKD
Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery
This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection…
- Conditions
- Kidney Tumors, CKD, Salt Substitute, Nephrectomy
- Trial name
- NCT07062952
- Testing
- Salt substitute
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jinling Hospital, China