Clinical trials: Open Abdomen
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Ventral Hernia, Ventral Incisional Hernia
Open Preperitoneal Mesh Versus Retromuscular Mesh Versus Suture Repair for Abdominal Wall Hernias
Randomized clinical trial comparing open preperitoneal mesh, retromuscular mesh and suture repair for ventral hernias less than 3 cm diameter
- Conditions
- Ventral Hernia, Ventral Incisional Hernia, Umbilical Hernia
- Trial name
- NCT03255239
- Testing
- Ventral hernia repair
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital Universitaire Taher Sfar
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hepatic Cirrhosis, Liver Fibrosis
A Study of Experimental Medication BMS-986036 Given to Healthy Participants
This is a study of experimental medication BMS-986036 given to healthy participants.
- Conditions
- Hepatic Cirrhosis, Liver Fibrosis, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
- Trial name
- NCT03445208
- Testing
- BMS-986036
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Ultrasonography, Educational Techniques
Near-peer Tutoring Compared With a Standard Faculty-led Course for Undergraduate Training in Abdominal Ultrasound.
Background: Ultrasound has become clinical skill widely used in most medical disciplines. Institutions are changing their curricula to implementing basic ultrasound knowledge, often supplementing traditional teaching with…
- Trial name
- SIGNATURE (NCT04114812)
- Testing
- Blended learning, Standard course
- Where
- 3 sites in Switzerland
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Bern
Incisional Ventral Hernia
Cytokine Response to Abdominal Wall Reconstruction
This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure.
- Trial name
- NCT07422584
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Inguinal Hernia, Indirect, Children, Only
Inflammatory Stress Response in Pediatric Inguinal Hernia Repair
Today there are various surgical techniques for inguinal hernia. In this study, investigators want to compare the ''PIRS'' operating technique laparoscopy and modified "Marcy" operating technique with open inguinal access.
- Conditions
- Inguinal Hernia, Indirect, Children, Only, Inflammatory Response, Surgery
- Trial name
- NCT03203343
- Testing
- Operation - PIRS, Operation - MARCY
- Where
- Croatia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Acute Appendicitis
Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPAC (NCT01022567)
- Testing
- Appendicectomy, Ertapenem
- Where
- 6 sites in Finland
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pre-Eclampsia, Placenta Diseases
Trial of Early Screening Test for Pre-eclampsia and Growth Restriction
A study of aspirin use in pregnancy to prevent high blood pressure and growth restriction of the fetus
- Conditions
- Pre-Eclampsia, Placenta Diseases, Eclampsia Preeclampsia, Fetal Growth Retardation
- Trial name
- TEST (NCT03674606)
- Testing
- Low dose aspirin
- Where
- 2 sites in Ireland
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Inguinal Hernia
Trial of Laparoscopic Compared to Open Inguinal Hernia Repair in Children Younger Than 3 Years
Laparoscopic techniques have been applied widely to the management of various common pediatric surgical diseases. Current evidence lacks sufficient quality to justify the widespread adoption of the laparoscopic approach to the…
- Trial name
- NCT00716768
- Testing
- Laparoscopic Inguinal Hernia Repair, Open Inguinal Hernia Repair
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Healthy
Lipid and Adipokine Profiles Following Subcutaneous Injection of ATX-101 Into Abdominal Fat Tissue
Open Label Study to Evaluate the Serum Lipid and Adipokine Profiles Following Subcutaneous Injection of ATX-101 into Abdominal Fat Tissue
- Trial name
- NCT01319916
- Testing
- ATX-101
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Abdominal Aortic Aneurysm
Screening for Abdominal Aortic Aneurysms in the General Practice by Ultraportable Ultrasound
Abdominal aortic aneurysm (AAA) is a localized dilatation of a segment of the aorta artery in its abdominal portion. It affects 1.7% of men aged 65 years and older.
- Trial name
- DACEP (NCT05617326)
- Testing
- AAA screening by a GP, AAA screening by a radiologist
- Where
- 6 sites in France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Central Abdominal Bulging
An Open-Label Study to Evaluate Retreatment With LIPO-202
Evaluate the safety of three 8-week courses of treatment with LIPO-202 in non-obese patients who have central abdominal bulging. Efficacy measurements will also be collected.
- Trial name
- NCT02397525
- Testing
- LIPO-202
- Where
- 8 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Neothetics, Inc
Inguinal Hernia, Chronic Pain
Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair
Groin hernia repair is a common procedure performed in approximately 2,000 patients per one million inhabitants. Severe chronic pain following groin hernia repair is seen in 2-5% of the patients indicating that a large number of…
- Trial name
- Trigger-open (NCT02065219)
- Testing
- Bupivacaine
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Total Abdominal Hysterectomy
Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
The Hypothesis of this study is that performing total abdominal hysterectomy using the newer electrocoagulation forceps, specifically, the gyrus open seal forceps, curved, compared to the traditional clamp \& suture technique…
- Trial name
- NCT00484835
- Testing
- Performing abdominal hysterectomy using gyrus electrocoagulation forceps
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern Health
İnguinal Hernia
Quality of Life Effects of Laparoscopic and Open Surgery in Inguinal Hernia Treatment
Inguinal hernia is the most common type of hernia, presenting with swelling and pain in the groin area as clinical signs of abdominal wall hernias. The gold standard treatment for symptomatic inguinal hernias is surgery.
- Trial name
- NCT06988293
- Testing
- inguinal hernia repair
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Hernia, Inguinal
Comparing Bi-level and Single-level ESP Block for Open Inguinal Hernia Repair
The goal of this clinical trial is to compare the effects of single-level and bi-level erector spinae plane block in open inguinal hernia repair surgery.
- Trial name
- NCT06155253
- Testing
- Erector spinae plane block
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Healthy
Open Label, Randomized Study of Low Concentration Ioforminol Injections for Use in Abdominal CECT in Healthy Volunteers
To optimize both the Ioforminol concentration and dosage(s) for CECT of the abdomen. To evaluate the safety and tolerability of low concentration Ioforminol Injections. Study recruits healthy volunteers.
- Trial name
- NCT01672996
- Testing
- Ioforminol 160 mgI/mL, Ioforminol 200 mgI/mL, Iopamidol 300 mgI/mL
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Healthy
Compare Bioavailability of RO7239361 After Subcutaneous Injection
Randomized study in healthy men and women. Assess the similarity of RO7239361 when injected into the arm, thigh, or the stomach. Collect data on safety of RO7239361.
- Trial name
- NCT03100630
- Testing
- RO7239361
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Febrile Morbidity
Vaginal Douching and Painting in Women Who Underwent Total Abdominal Hysterectomy
Comparison of the effectiveness of povidone-iodine douching and painting for reducing febrile morbidity after total abdominal hysterectomy
- Trial name
- NCT03537313
- Testing
- Vagina douching, Vagina painting
- Where
- Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand