Clinical trials: Oocyte Maturation
HCG Day Follicle Diameter, Reproduction Results
Comparison of Follicle Diameter on hCG Day and Follicle Diameters on OPU (Oocyte Pick up) Day and the Effect of Follicle Diameters on Embryo Development and Pregnancy Outcomes
Evaluation of follicle diameters on human chorionic gonadotrophin(hCG) day and oocyte pick up (OPU) day of follicles developing after gonadotropin treatment, the relationship between follicle diameter and maturation in oocytes…
- Trial name
- NCT04679688
- Testing
- descriptive
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova…
- Trial name
- NCT00986687
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- UConn Health
Controlled Ovarian Stimulation, Progesterone Variation on Trigger Day
Progesterone Variation on the Final Day of Oocyte Maturation.
The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retrieval before the ovulation triggering, by…
- Conditions
- Controlled Ovarian Stimulation, Progesterone Variation on Trigger Day, Circadian Rhythm, Oocyte Donors
- Trial name
- NCT03366025
- Testing
- Serum progesterone measure
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
OVARIAN STIMULATION
Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity
Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes.
- Trial name
- NCT06839274
- Testing
- transvaginal Ultrasound
- Where
- United Arab Emirates
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Embryo Development
Culture Media and Blastocyst Development
The aim of this non-interventional study is to compare the blastulation rate per fertilized oocyte in two different single step culture media commercially available (GEMS and Irvine culture media).
- Trial name
- NCT03497052
- Testing
- In vitro culture in medium 1, In vitro culture in medium 2
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clinica Valle Giulia
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Progesterone Resistance
Step Down FSH Approach and Late Follicular Phase in Progesterone Level
Step-down approach and late follicular phase progesterone level
- Trial name
- FSH (NCT03356964)
- Testing
- follicle stimulating hormone
- Where
- United Arab Emirates
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Endometrial Receptivity, Ovarian Hyperstimulation Syndrome
Gene Expression Profile After Gonadotropin Releasing Hormone (GnRH) Agonist Trigger of Oocyte Maturation
The purpose of this study is to compare gene expression profiles in endometrial biopsies during the window of implantation after triggers of oocyte maturation using GnRH agonist or hCG and compared with their natural cycles in…
- Trial name
- NCT01606709
- Testing
- GnRH agonist, hCG
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- UConn Health
Vascular Endothelial Growth Factor Overexpression
Differential Regulation of VEGF, Cadherin, Angiopietin 2 by Trigger Oocyte Maturation With GnRHa vs hCG in Donors
Introduction OHSS still remains a complication of assisted reproduction treatments. hCG administration to trigger final oocyte maturation will release vascular mediators, being VEGF and other proteins such as VE-Cadherin or…
- Trial name
- NCT00848185
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility, Pregnancy, Multiple
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization
The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.
- Trial name
- EMECH (NCT02530892)
- Testing
- EmbryoHug
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stanford University
Embryo Development
Effect of Abstinence Duration on Embryo Development
The aim the investigators study is to analyze the embryo development if oocytes of the participants are injected with sperm from a longer or shorter (2 hours) abstinence duration.
- Trial name
- NCT03323892
- Testing
- second masturbation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Ovarian Reserve
CD133 Transplantation to Generate Oocytes in Poor Ovarian Reserve
Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developped nevertheless none of them optimal: the number of…
- Trial name
- NCT01966536
- Testing
- CD133+ cells transplantation into ovarian artery of one ovary
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Infertility
Results Following the Vitrification of Human Oocytes Using 2 Methodologies
The investigators are going to compare embryo developmental rates of human eggs following freezing in two different freezing methods.
- Trial name
- NCT01033474
- Where
- Peru
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Reproductive Sciences
Oocyte Competence
Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes).
- Trial name
- NCT03683290
- Testing
- Image acquisition and analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Ovarian Hyperstimulation Syndrome
Endometrial Receptivity After GnRH Agonist Triggering
Conventional luteal phase support after human chorionic gonadotrophin (hCG) triggering in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) provides adequate pregnancy rates and live birth rates…
- Trial name
- ERAMAD (NCT01500863)
- Testing
- hCG, triptorelin, Triptorelin, estradiol valerate, micronized vaginal progesterone
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Ovarian Stimulation, Human Chorionic Gonadotropin
The Effect of Dual Trigger (GnRH Agonist + hCG) for Final Maturation in Oocyte Donors With History of a Previous Cycle With Suboptimal Response to GnRH Agonist Only Trigger
The goal of this clinical trial is to compare GnRH-agonist trigger with dual GnRH-agonist and HCG trigger in oocyte donors. The main questions it aims to answer are: Maturation rate (Metaphase II/ Total number of COCs collected)…
- Conditions
- Ovarian Stimulation, Human Chorionic Gonadotropin, Oocyte Donors
- Trial name
- NCT06142708
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), GnRH-agonist only trigger
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embryolab Fertility Clinic
Infertility, Female
CAPA In-vitro Oocyte Maturation (CUHK Medical Centre Limited)
In vitro oocyte maturation (IVM) is a mild-approach assisted reproductive technology (ART). Because of its simplicity, the more favorable financial implications (reduced cost) for patients, and the lower health risk profile of…
- Trial name
- NCT07083427
- Testing
- CAPA-IVM
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin
GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
The aim of this study is to analyze the effectiveness of GnRh antagonist in the treatment of early ovarian hyperstimulation syndrome.
- Conditions
- Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin, Oocyte Maturation
- Trial name
- NCT01268761
- Testing
- GnRH antagonist (Cetrorelix)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Female
CAPA In-vitro Oocyte Maturation
In vitro oocyte maturation (IVM) is a mild-approach assisted reproductive technology (ART). Because of its simplicity, the more favorable financial implications (reduced cost) for patients, and the lower health risk profile of…
- Trial name
- NCT06984081
- Testing
- CAPA IVM
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Infertility
Follicular Flushing Versus Direct Aspiration
The purpose of this study is to investigate the impact of follicular flushing on the oocyte recovery rate, oocyte maturity, fertilization rate, and embryo development and utilization as compared to direct aspiration (no flushing)…
- Trial name
- NCT03354858
- Testing
- Follicular flushing
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eugonia