Clinical trials: Oligospermia
Infertility, Male, Sperm Count, Low
Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.
It has been described that 11% of men with semen values within the normal range established by the World Health Organization (WHO) have sperm DNA fragmentation.
- Trial name
- ZYMOT2 (NCT06384794)
- Testing
- Sperm capacitation through the ZyMōt®Sperm Separation Device®, Swim-up
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Oligoasthenoteratozoospermia
Severe Male Factor Infertility Management
This study is the first to evaluate the effect of oral supplementation with antioxidants combined with lifestyle modification for severe male factor partner of couples undergoing ICSI.
- Trial name
- OAT (NCT02752555)
- Testing
- Antioxidant (l-cratinine) + modifiable lifestyle factors
- Where
- 3 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Idiopathic Infertility
Effect of Pentoxifylline and Zinc Co-administration in Patients With Oligoasthenoteratozoospermia
The aim of this study is to investigate the impact of co-administration of Pentoxifylline and Zinc sulfate on oxidative stress, apoptosis, and inflammation, sperm capacitation and parameters in infertile men.
- Trial name
- OAT (NCT05156684)
- Testing
- Pentoxifylline, zinc, zinc + pentoxifylline
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Arak University of Medical Sciences
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Infertility, Male
NAPO - Novel Approach for Oligospermia
This randomized controlled trial aims to assess whether treatment with denosumab can improve semen quality in infertile men selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker, and with severely…
- Trial name
- NAPO (NCT06300229)
- Testing
- Denosumab, sodium chloride
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Martin Blomberg Jensen
Idiopathic Oligoasthenoteratozoospermia, Male Infertility
Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.
This is a randomized clinical trial evaluating the efficacy of Letrozole, L-Carnitine, and their combination on sperm quality, oxidative stress, and ART outcomes in men with idiopathic oligoasthenoteratozoospermia.
- Trial name
- NCT07669402
- Testing
- Letrozole 2.5mg, L-carnitine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Azoospermia, Nonobstructive, Teratospermia
Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®
The study is open to patients with severe forms of male infertility (non-obstructive disorders of spermatogenesis, including azoospermia).
- Conditions
- Azoospermia, Nonobstructive, Teratospermia, Oligospermia, Men Infertility
- Trial name
- MARS (NCT06869863)
- Testing
- Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months.
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Oligoasthenoteratozoospermia, Male Infertility
Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
Objective of the study is to compare the efficacy of tamoxifen alone \& tamoxifen with antioxidant on semen quality of infertile male with abnormal parameters (sperm count, motility, vitality, morphology) .Infertility is defines…
- Trial name
- NCT05200663
- Testing
- Tab Tamoxifen 10 mg, Tab Tamoxifen 10mg,Cap vitamin E 400mg
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Male Infertility
Administration of Antioxidants to Infertile Men and Sperm Quality
The purpose of this randomized clinical trial is to assess the effect of oral antioxidant administration to infertile men, by evaluating semen variables, sperm DFI and levels of ROS.
- Trial name
- NCT04256278
- Testing
- Spermotrend
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Cylinical Embryo, Oligospermia
Sperm Pathology Samples and Morphokinetics
The embryo kinetics may be a new prognostic factor for choosing the embryos with the highest implantation potential. In order to identify the factors that may affect the rate of embryo cleavage, there are many studies about…
- Trial name
- NCT02155179
- Where
- 2 sites in Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- IVI Madrid