Clinical trials: Ocular Infections, open to volunteers
Corneal Neovascularization
Corneal Crosslinking for Treatment of Corneal Neovascularization
The study objective is to assess safety and efficacy of photo-activation of riboflavin for treatment of corneal neovascularization with or without concomitant inflammation and/or infection.
- Trial name
- NCT04787471
- Testing
- 30 minute photoactivation of riboflavin 0.1%, 10 minute photoactivation of riboflavin 0.1%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Price Vision Group
Uveitis, Aqueous Humor
Metagenomics for Ocular Inflammation
The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available…
- Conditions
- Uveitis, Aqueous Humor, Infection
- Trial name
- NCT06974162
- Testing
- Metagenomic sequencing of aqueous humor, Ocular Imaging
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Conjunctivitis, EBV Infection
Investigating Epstein-Barr Virus Associated Conjunctivitis
Conjunctivitis means inflammation of the conjunctiva, the thin transparent layer over the white of the eye and under the eyelids.
- Trial name
- EBV Conj (NCT06689397)
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Chronic Myeloproliferative Disorders, Cognitive/Functional Effects
Registry of Older Patients With Cancer
RATIONALE: Gathering information about older patients with cancer may help the study of cancer in the future. PURPOSE: This research study is gathering information from older patients with cancer into a registry.
- Conditions
- Chronic Myeloproliferative Disorders, Cognitive/Functional Effects, Leukemia, Lymphoma
- Trial name
- NCT01137825
- Where
- 7 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Hepatitis B, Chronic
Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION]
This is a Phase II Investigator-Initiated Study to understand the vaccinal effect of HBsAg monoclonal Ab VIR-3434 in chronic hepatitis B infection.
- Trial name
- NCT06216470
- Testing
- VIR-3434
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Central Nervous System Inflammation, MOG-IgG Associated Disease
Azathioprine in MOGAD
MOG-IgG associated disease (MOGAD) is a rare inflammatory disease of the central nervous system recently described. Initially reported as monophasic, data from incident cohorts suggests that around 50% of adult patients with…
- Trial name
- MOGwAI (NCT05349006)
- Testing
- Azathioprine
- Where
- 17 sites in France
- Volunteers
- 126 people
- Sponsor
- Hospices Civils de Lyon
Corneal Ulcer
Follow-up Compliance for Corneal Ulcer Patients With SMS Reminder
Corneal ulcer is defined as the loss of corneal epithelium with underlying stromal infiltration and suppuration, accompanied by signs of inflammation, with or without hypopyon1.
- Trial name
- NCT07377513
- Testing
- SMS reminder
- Where
- Nepal
- Volunteers
- 310 people
- Sponsor
- Seva Canada Society
Uveitis, Infectious Uveitis
Genetics of Uveitis
In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify…
- Trial name
- NCT02357238
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chronic Myeloproliferative Disorders, Leukemia
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT01137643
- Testing
- biologic sample preservation procedure, cytology specimen collection procedure
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Eye Care, Nursing Care
Effects of Two Different Eye Care Practices on Eye Complications in Mechanically Ventilated Intensive Care Patients
This study was designed as a prospective, randomized controlled experimental study aiming to compare different approaches to eye care in intensive care patients receiving mechanical ventilation.
- Conditions
- Eye Care, Nursing Care, Intensive Care Unit
- Trial name
- NCT07070843
- Testing
- Control Group: Standard Eye Care Group, Intervention Group 1: Eye Care Using an Eye Care Kit, Intervention Group 2: Eye Care According to an Eye Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Istanbul Saglik Bilimleri University
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Fungal Keratitis, Corneal Ulcer
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
The goal of this clinical trial is to learn if adjunctive topical Cyclosporine A eye drops combined with standard of care topical Natamycin treatment improves vision outcomes in patients with fungal keratitis.
- Trial name
- FANCY (NCT06658002)
- Testing
- Cyclosporine A
- Where
- 2 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Endophthalmitis
Nanopore Sequencing in Ophthalmology
In this pilot study, the feasibility of the Oxford Nanopore MinION to identify pathogens from vitrectomy samples in eyes with endophthalmitis shall be assessed.
- Trial name
- NCT05372861
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Cataract Surgery, Ocular Infections
Efficacy of EPD-09-25 for Eyelid Hygiene Before and After Eye Surgery.
This is an interventional, open-label, two-arms clinical trial, randomized 1:1 (EPD treatment or no eyelid hygiene treatment) in patients scheduled for eye surgery (cataract surgery).
- Trial name
- NCT07418333
- Testing
- EPD Eyelid wipes
- Volunteers
- 100 people
- Sponsor
- VISUfarma SpA
Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma
Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers
The study involves enrollment of patients with sebaceous carcinoma, Merkel's carcinoma, Porocarcinoma, Melanoma, and squamous cell Ca of the ocular surface and adnexa both primary and relapsed after surgical and/or…
- Conditions
- Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma, Ocular Surface Squamous Neoplasia, Merkel Cell Carcinoma, Unspecified
- Trial name
- BLS (NCT05797415)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Periodontal Diseases, Periodontal Diseases Inflammation
Retinal and Choroidal Changes in Periodontal Disease
Advanced PeriodontitisIn this cross-sectional study, the relationship between periodontal disease severity and retinal and choroidal structural changes was evaluated using SD-OCT.
- Conditions
- Periodontal Diseases, Periodontal Diseases Inflammation, Retinal Thickening
- Trial name
- NCT07856901
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zeliha Başak Çakır Erdil
Herpes Simplex Keratitis, Corneal Neovascularization
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action.
- Trial name
- NCT07329686
- Testing
- Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
CMV Retinitis
Evaluation of Safety and Efficacy of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.
The goal of this exploratory clinical study is to evaluate the safety and efficacy of Cytomegalovirus-Specific T cells (LB-DTK-CMV) to treat patients diagnosed with antiviral-resistant and refractory cytomegalovirus retinitis.
- Trial name
- NCT07679412
- Testing
- LB-DTK-CMV
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- LucasBio
Graves Disease, Graves' Disease in Remission
Graves' Disease Induced by Epstein-Barr Virus Lytic Reactivation
Previous studies have proved that the lytic reactivation of latent Epstein-Barr virus (EBV) was significantly associated with the onset of Graves'disease (GD), however, the morbidity of GD and recurrence rate of hyperthyroidism…
- Conditions
- Graves Disease, Graves' Disease in Remission, Epstein-Barr Virus
- Trial name
- NCT06426758
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiao-Ming Mao