Clinical trials: Occipital Nerve Block
Migraine
Research Study of Greater Occipital Nerve Block As A Treatment For Prolonged Migraine Attacks
Greater Occipital Nerve Blocks (GONB) are a common procedure used for the treatment of headache. The GONB procedure involves a series of injections into the greater occipital nerve (a spinal nerve located at the back of your…
- Trial name
- NCT00329732
- Testing
- 0.5% bupivicaine and 2% lidocaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Thomas Jefferson University
Migraine, Headache
Amitriptyline vs GON and SON Blocks in Migraine
Comparison of efficacy and safety of amitriptyline and nerve blocks
- Trial name
- NCT04750967
- Testing
- Lidocaine 1% Injectable Solution, Amitriptyline
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Neck Pain, Myofacial Pain Syndrome
Efficacy of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients With Neck Pain
Study Title: Evaluation of the Effectiveness of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients with Neck Pain Due to Upper Trapezius Trigger Points: A Single-Blind Randomized Controlled Trial Purpose…
- Conditions
- Neck Pain, Myofacial Pain Syndrome, Trigger Point Pain, Myofascial, Trigger Points
- Trial name
- NCT07058636
- Testing
- 2% Lidocaine HCl + saline, Steroid+lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Migraine Disorders, Medication Overuse Headache
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Migraine is among the leading causes of disability worldwide. Inappropriate use of acute medications in the setting of primary headache, particularly migraine can result in a debilitating condition known as medication overuse…
- Conditions
- Migraine Disorders, Medication Overuse Headache, Greater Occipital Nerve Block
- Trial name
- GONB_MOH (NCT07568496)
- Testing
- Lidocaine 2% and Methylprednisolone 80 mg
- Where
- 3 sites in Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Headache, Migraine
Treatment Response to GON Pulsed Radiofrequency in Elderly Patients With Chronic Migraine
Headache disorders are highly prevalent in older adults, yet their management remains challenging due to comorbidities, polypharmacy, and the paucity of evidence derived from geriatric populations.
- Trial name
- FRAIL-GON (NCT07363083)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine, Chronic Migraine, Headache
A Study Investigating the Efficacy of GON Blocks.
Greater occipital nerve block ("GON block") is carried out extensively in the treatment of chronic migraine, but more research is required to understand the effectiveness of the procedure.
- Trial name
- NCT04017741
- Testing
- Combined Depo-Medrone and Lidocaine, Sodium Chloride 0.9% Inj
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Barts & The London NHS Trust
Medication-overuse Headache, Treatment
Treatment Response in Patients With Medication-Overuse Headache
The aim of this study to evaluate pre-injection patient-related factors that may influence treatment response in patients with medication-overuse headache who underwent ultrasound-guided greater occipital nerve block.
- Conditions
- Medication-overuse Headache, Treatment, Headache, Greater Occipital Nerve Block
- Trial name
- NCT07487649
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan 1. Murat State Hospital
Episodic Migraine
Efficacy of Nerve Blocks for Episodic Migraine
The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose…
- Trial name
- NCT05734625
- Testing
- Bupivacaine HCl 0.5% Injectable Solution, Methylprednisolone 40 MG Injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Headache, Occipital Nerve Block
Steroids in Occipital Nerve Block for Treatment of Headache
Currently there is limited evidence of benefit for the addition of steroids to occipital nerve blocks for treatment of headache, and not all steroids have been explored.
- Trial name
- NCT05732532
- Testing
- Bupivacaine, Lidocaine, Dexamethasone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Migraine
A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache
Subjects are scheduled to undergo a Greater Occipital Nerve Block (GONB) as treatment for your chronic daily headache (CDH). GONB has been used for many years in the treatment of headaches.
- Trial name
- NCT00203294
- Testing
- lidocaine, bupivicaine and saline, lidocaine plus bupivicaine plus triamcinolone (steroid)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Thomas Jefferson University
Headache, Cervicogenic Headache
Greater Occipital Nerve Pulsed Radiofrequency in Cervicogenic Headache
The effect of GON PRF treatment applied with USG-guided proximal technique in patients who do not respond to conservative treatments for cervicogenic headache
- Conditions
- Headache, Cervicogenic Headache, Occipital Nerve Block, Pulsed Radiofrequency
- Trial name
- GONPRFCEH (NCT06764433)
- Testing
- GONPRF, Proximal GONPRF
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine Disorders
Greater Occipital Nerve (GON) Block Effectivity in the Treatment of Chronic Migraine: 6 Months Follow up
This study evaluates effectiveness of greater occipital nerve blocks with bupivacaine compared to placebo in chronic migraine patients.
- Trial name
- GON (NCT02578719)
- Testing
- bupivacaine, saline
- Sponsor
- Bozok University
Post-Dural Puncture Headache
Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH
Management of postdural puncture headache (PDPH) has always been challenging for anesthesiologists. PDPH not only increases the misery of the patient, but the length of stay and overall cost of treatment in the hospital also…
- Trial name
- NCT05235256
- Testing
- bilateral sphenopalatine ganglion block, bilateral greater occipital nerve block, lidocaine plus dexamethasone
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Post-Dural Puncture Headache
Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache
Dural puncture during neuroaxial procedures is the most frequent major complication that causes the development of post-dural puncture headache (PDPH) in 16%-86% of cases.
- Trial name
- NCT06470854
- Testing
- Nebulized Dexmedetomidine, Bilateral greater occipital nerve block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Migraine
Greater Occipital Nerve Block Versus Pulse Radiofrequency in Migraine
The aim of the study is to evaluate the clinical efficacy of the repeated greater occipital nerve(GON) blokcs with GON pulse radiofreaquency (PRF)
- Trial name
- GON-B/PRF (NCT06345326)
- Testing
- Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Adiyaman University Research Hospital
Chronic Migraine
GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache.
- Trial name
- DHC-GON-1 (NCT02686983)
- Testing
- Betamethasone and local anesthetic
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Jakob Møller Hansen, MD.
Migraine Disorders
Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in Migraine Headache Prophylaxis
The goal of this randomized controlled study in Thailand. is to find if there is a role of local anesthetic greater occipital nerve block at Cervical spine level 2 under ultrasound guide in prophylaxis of episodic migraine and…
- Trial name
- NCT06432127
- Testing
- Bupivacaine
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Mahidol University
Greater Occipital Nerve Block, Medical Treatment
Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment
The aim of this work is to assess the efficacy of ultrasound guided greater occipital nerve block either by local anesthetic or by botulinum toxin in comparison to medical treatment in prevention of chronic migraine.
- Conditions
- Greater Occipital Nerve Block, Medical Treatment, Chronic Migraine
- Trial name
- NCT06122545
- Testing
- Greater Occipital Nerve Block, Medical Treatment, bupivacaine or onabotulinum toxin A injection.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Migraine Headache
Greater Occipital Nerve Block for Migraine Prophylaxis
Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized…
- Trial name
- NCT00915473
- Testing
- bupivicaine, normal saline, methylprednisolone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic