Clinical trials: Obstructive Sleep Apnea
Obstructive Sleep Apnea, Obesity
Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese
This study evaluates the effectiveness of intraoral appliance in the treatment of obstructive sleep Apnea Syndrome in class III obese in comparison to an adjustable silicone appliance.
- Trial name
- NCT03517150
- Testing
- mandibular advancement device
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea
Surgical Treatment for Patients With Obstructive Sleep Apnea by Using Da Vinci SP Surgical System
This prospective, interventional, non-randomized, single arm, clinical trial will investigate feasibility and safety of trans-oral robotic surgery using da Vinci SP Surgical System in Taiwan for the surgical treatment of OSA.
- Trial name
- NCT06766760
- Testing
- Da Vinci SP Surgical System, Model SP1098
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Obstructive Sleep Apnea of Adult
Change in Tongue Strength and Fatigue After Upper Airway Stimulation Therapy
Upper airway stimulation (UAS) is an effective surgical alternative for patients with obstructive sleep apnea (OSA) who fail continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT03980158
- Where
- Germany
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity receiving positive airway pressure (PAP)…
- Trial name
- NCT07794397
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Sleep Apnea, Obstructive
Myofunctional Training for Obstructive Sleep Apnea Patients After Transoral Robotic Surgery
Background: Obstructive Sleep Apnea Syndrome (OSA) is a kind of sleep disorder. The symptoms are intermittent, partial or complete upper airway collapse, seriously impacting oxygen saturation and oxidative stress.
- Trial name
- NCT04876482
- Testing
- transoral robotic surgery, oral appliance, using continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 81 people
- Sponsor
- National Cheng-Kung University Hospital
The Effects of Obstructive Sleep Apnea on Blood Pressure Measurement
Blood Pressure and Obstructive Sleep Apnea
Bidirectional and causal relationship exists between obstructive sleep apnea (OSA) and hypertension in a dose-response manner, independent of confounding variables such as age, smoking, and body mass index.
- Trial name
- NCT06027424
- Where
- Taiwan
- Volunteers
- 2,037 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Stroke, Transient Ischemic Attack
SLEep APnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke
Obstructive sleep apnea (OSA) is common after stroke/TIA and, left untreated, is associated with recurrent vascular events, poor functional outcomes, and long-term mortality.
- Conditions
- Stroke, Transient Ischemic Attack, Obstructive Sleep Apnea
- Trial name
- SLEAP SMART (NCT02454023)
- Testing
- Portable sleep monitor (ApneaLink Air), In-laboratory polysomnography
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre
Mild Obstructive Sleep Apnea Syndrome
Continuous Positive Airway Pressure and Oral Appliances Treatments in Mild Obstructive Sleep Apnea
Treatment response of mild obstructive sleep apnea (OSA) to continuous positive airway pressure (CPAP) therapy and oral appliance (OA) is still controversial.
- Trial name
- OSAS (NCT01461486)
- Testing
- Continuous Positive Airway Pressure (CPAP), Oral Appliance (BRD)
- Where
- Brazil
- Volunteers
- 79 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Obstructive Sleep Apnea, Malocclusion
Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet
This research aims to provide pediatric patients with polysomnography (a sleep study) before and after orthodontic treatment to determine if the extraction of upper premolars for treating excessive overjet results in an increase…
- Trial name
- NCT04946201
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mohamed Bazina
Hypertension, Sleep Apnea
Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
Obstructive sleep apnea (OSA) is a highly prevalent condition in hypertensive patients. The renin-angiotension-aldosterone-system (RAAS) has a central role in blood pressure control.
- Trial name
- LosartanPAP (NCT00701428)
- Testing
- Losartan, CPAP
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Skaraborg Hospital
Obstructive Sleep Apnea, IgA Nephropathy
The Effect of OSA on Severity and Prognosis of Patients With IgAN
This study aims to investigate the influence of obstructive sleep apnea hypopnea syndrome (OSA) on the severity and prognosis of patients with IgA nephropathy (IgAN), and to evaluate the therapeutic effect of continuous positive…
- Trial name
- NCT06393036
- Testing
- Continuous Positive Airway Pressure
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation
Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019.
- Trial name
- NCT07047092
- Testing
- Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP)
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcoidosis, Sleep Apnea, Obstructive
Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status
Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide without known pathogenesis, and the role of comorbidities has not been fully assessed in the scientific literature.
- Conditions
- Sarcoidosis, Sleep Apnea, Obstructive, Fatigue
- Trial name
- SARCOIDOSAS (NCT03926832)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Asthma, Obstructive Sleep Apnea Syndrome
CPASMA: Is There an Improvement in Asthma in Patients With Both Asthma and OSAS Treated With CPAP?
The CPASMA trial is a descriptive, prospective, multicentre clinical trial, with a before/after Continuous Positive Airway Pressure (CPAP) assessment in participating patients.
- Trial name
- CPASMA (NCT01374932)
- Testing
- CPAP
- Where
- 10 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Cimera
Obstructive Sleep Apnea
Rapid Maxillary Expansion for Residual Pediatric
Randomized Controlled Trial comparing Rapid Maxillary Expansion with Standard Clinical Practice in patients with residual pediatric Obstructive Sleep Apnea Syndrome after adenotonsillectomy.
- Trial name
- ERMES (NCT02947464)
- Testing
- Standard clinical practice, Standard clinical practice + Rapid Maxillary Expansion
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Hypertension
Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- nebhctz (NCT02710071)
- Testing
- Nebivolol, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Evaluation of Acclimate Feature for Positive Airway Pressure (PAP) Therapy
The purpose of the study is to evaluate if using the Acclimate feature at the beginning of Positive Airway Pressure (PAP) therapy results in patients using their PAP therapy at least as long as they would standard therapy.
- Trial name
- NCT01421654
- Testing
- S9 Elite with Acclimate, S9 Elite
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ResMed
Obstructive Sleep Apnea, Heart Failure
Mandibular Advancement Device for Treatment of Obstructive Sleep Apnea and Its Impact on Cardiac Remodeling
Primary aim: The MOSAIC trial aims to assess the impact of a mandibular advancement device (MAD) on Apnea-Hypopnea Index (AHI) in Asian patients with Heart Failure with reduced Ejection Fraction (HFrEF) and obstructive sleep…
- Trial name
- MOSAIC (NCT02948894)
- Testing
- Mandibular advancement device
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National University of Singapore
Obstructive Sleep Apnea
Impact of Telemonitoring to Improve Adherence in Continuous Positive Airway Pressure (CPAP)-Treated Patients
Improvement in CPAP adherence can be obtained by usingTelemonitoring. T4P® is a telemonitoring unit added on CPAP device allowing to obtain a daily report of usage duration, mask leaks, pressure and apnea-hypopnea index.
- Trial name
- NCT02773953
- Testing
- T4PTelemonitoring, CPAP
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre