Clinical trials: Obsessive-compulsive Disorders and Symptoms
Obsessive-compulsive Disorders and Symptoms in Children
Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children
This study will use magnetic resonance imaging (MRI) to assess the function and structure of overlapping task control circuits in children with a range of Obsessive-Compulsive symptoms (OCS).
- Trial name
- NCT03584945
- Testing
- Cognitive Behavioral Therapy, Community Referral as appropriate
- Where
- 2 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"
The investigators are examining whether difficulties with cognitive control (i.e., the ability to stop one's thought process and shift attention) is a common problem across three types of repetitive, negative thinking: obsessions…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT03414619
- Testing
- Cognitive Control Tasks and Script Driven Imagery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder and Symptoms
Brief Anxiety Sensitivity Treatment for Obsessive Compulsive Symptoms
Obsessive-compulsive disorder (OCD), characterized by recurrent obsessions and/or compulsions, is a disabling psychiatric condition affecting approximately 2-3% of the population.
- Trial name
- COAST (NCT02635178)
- Testing
- Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Florida State University
Posttraumatic Stress Disorder, Somatization
Intervention Through EMDR and CBT With Women Victim of Childhood Sexual Abuse. A Randomized Controlled Trial.
This study evaluates the effectiveness of two types of therapy for the treatment of sexual abuse psychological impact on a sample of Spanish women.
- Conditions
- Posttraumatic Stress Disorder, Somatization, Obsessive-Compulsive Disorder, Depression
- Trial name
- NCT04813224
- Testing
- TRAUMA CENTERED EMDR-BASED TREATMENT and TRAUMA-FOCUSED CBT-BASED TREATMENT
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Internacional de Valencia
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Panic Disorder
Evaluating the Effects of Stress in Pregnancy
This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy.
- Conditions
- Depression, Panic Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00525226
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Social Anxiety, Generalized Anxiety
Imagery Rescripting and Imaginal Exposure for Anxiety Symptoms
This study will recruit 460 participants who self-report high symptoms of anxiety. Participants will be randomly assigned to one of 4 groups: one analog intervention of Imagery Rescripting (IR) for memories, an analog…
- Conditions
- Social Anxiety, Generalized Anxiety, Obsessive-Compulsive Symptom, Panic
- Trial name
- NCT05292807
- Testing
- Imaginal exposure for memories, Imaginal exposure for future events, Imagery rescripting for memories
- Where
- Israel
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Hebrew University of Jerusalem
Obsessive Compulsive Disorder
Neural Mechanisms of CBT Response in Hoarding Disorder
The purpose of this research is to measure changes in brain activity with functional magnetic resonance imaging (fMRI) before and after cognitive-behavioral therapy for compulsive hoarding.
- Trial name
- NCT01956344
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Hoarding Disorder, Virtual Reality Based Therapy
Non-Immersive Virtual Environments for the Treatment of Hoarding Disorder
This experimental trial investigates whether Virtual Reality Exposure (VRe) helps individuals reduce the difficulty of discarding personal possessions. It will also evaluate the psychological state impacts of the intervention.
- Conditions
- Hoarding Disorder, Virtual Reality Based Therapy, General Population (no Specific Condition or Disease)
- Trial name
- HD&VR (NCT07160543)
- Testing
- Imagination Exposure, Non-immersive Virtual Reality Exposure
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Padova
Adult ALL, Post-traumatic Stress Disorder
Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
The Eye Movement Desensitization and Reprocessing Protocol (EMDR) was first developed by Francine Shapiro in 1987 and can be adapted for online and in presence administration.
- Conditions
- Adult ALL, Post-traumatic Stress Disorder, Obsessive-Compulsive Disorder, Disgust
- Trial name
- MDL (NCT06110702)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Behavior, Depressive Disorder
Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time
This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric…
- Conditions
- Behavior, Depressive Disorder, Anxiety Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- CABxtime (NCT06705179)
- Testing
- Behavioral task performance
- Where
- 2 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- California Institute of Technology
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Romano-Ward Syndrome, Long QT Syndrome
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.
The objectives of the study are to investigate if KCNQ1 mutation in Romano-Ward long QT patients can be associated with changes in insulin regulation and with psychological features of compulsivity, impulsivity and behavioural…
- Conditions
- Romano-Ward Syndrome, Long QT Syndrome, Compulsive Behavior, Healthy Individuals
- Trial name
- PRIME (NCT04715256)
- Testing
- Cognitive assessment of obsessive-compulsive and impulsive behaviours, Genomic analysis, Glucoregulation assessment
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biotrial
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Background: PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors.
- Trial name
- NCT03507218
- Where
- 8 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Impulsive Behavior, Impulse Disorders
Clinical Response of Impulsivity After Brain Stimulation in Parkinson's Disease
The objective of this prospective observational cohort study is to answer the following clinically important questions: 1. In patients with a pre-operative history of ICBs, what is the likelihood of improvement or deterioration…
- Conditions
- Impulsive Behavior, Impulse Disorders, Gambling, Pathological, Eating, Binge
- Trial name
- CRIPS (NCT04811807)
- Testing
- Subthalamic Nucleaus Deep brain stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King's College London
Obsessive Thoughts
Study of the Efficacy of GGRO: a Novel Cognitive Training App
The aim of the present study was to evaluate the efficacy of GGRO reducing OCD related maladaptive beliefs and OCD symptoms. Specifically, a randomized controlled trial with crossover design was carried out in non-clinical…
- Trial name
- GGRO (NCT03571464)
- Testing
- GGRO Mobile App
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Tourette Syndrome, Obsessive-Compulsive Disorder
Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what…
- Conditions
- Tourette Syndrome, Obsessive-Compulsive Disorder, Sensory Disorders
- Trial name
- SenST-Plus (NCT04335175)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD)
Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder
This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder.
- Conditions
- Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD), Obsessive Compulsive Behavior, Substance Abuse Disorder
- Trial name
- NCT07395453
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University