Clinical trials: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy
Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients
The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD).
- Conditions
- Obsessive-Compulsive Disorder, Virtual Reality Exposure Therapy, Virtual Reality Cognitive Training, Cognitive Behavior Therapy
- Trial name
- OCD-VRET1 (NCT07245134)
- Testing
- Exposure Therapy (Virtual Reality), Cognitive flexibility training, Standard CBT program without VR interventions
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Obsessive Compulsive Disorder
Precision Analytic Research Methods in OCD
Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments.
- Trial name
- NCT07011901
- Testing
- Exposure and Response Prevention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obsessive-Compulsive Disorder, Psychiatric Disorder
Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
The purpose of this randomized, sham-controlled study is to evaluate the effectiveness of DBS therapy in individuals suffering from severe OCD and to investigate DBS treatment with functional [18F]FDG-Brain-PET.
- Trial name
- OCDBS (NCT05577598)
- Testing
- Implantation of a DBS therapy system
- Where
- Austria
- Volunteers
- 8 people
- Sponsor
- Medical University of Vienna
Obsessive-Compulsive Disorder
Metacognitive Therapy for Patients With Obsessive-Compulsive Disorder
Cognitive behavior therapy is the most effective treatment of obsessive-compulsive disorder. However, the majority of treated patients remain symptomatic.
- Trial name
- NCT01483339
- Testing
- Metacognitive Therapy, Exposure and Response Prevention
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Philipps University Marburg
Panic Disorder, Social Anxiety Disorder
Evaluation of Primary Care Behavioral Health (PCBH) With the Addition of Self-help CBT - A Randomized Multicenter Trial
In this multicenter study, the investigators want to find out if an addition of an diagnostic assessment and possibility of treatment with guided self-help CBT can increase the treatment effects of PCBH on patient functioning and…
- Conditions
- Panic Disorder, Social Anxiety Disorder, Depression, Hypochondriasis
- Trial name
- KAIROS (NCT04900064)
- Testing
- Brief interventions, Self-help CBT
- Where
- 4 sites in Sweden
- Volunteers
- 1,242 people
- Sponsor
- Linnaeus University
Obsessive-compulsive Disorders and Symptoms, Obsessive Thoughts
Internet-delivered CBM-C for OC-symptoms
A factorial randomised controlled trial comparing internet-delivered combined cognitive bias modification intervention (iCBM-C) versus internet-delivered CBM-interpretation intervention (iCBM-I), internet-delivered CBM-attention…
- Conditions
- Obsessive-compulsive Disorders and Symptoms, Obsessive Thoughts, Obsessive Compulsive Behavior
- Trial name
- NCT04575805
- Testing
- Internet-delivered Combined Cognitive Bias Modification (iCBM-C), Internet-delivered Cognitive Bias Modification-Interpretation (iCBM-I), Internet-delivered Cognitive Bias Modification-Attention (iCBM-A)
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Dokuz Eylul University
Obsessive Compulsive Disorder
N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD)
Several lines of evidence implicate glutamatergic dysfunction in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine, also known as N-methylglycine, is an endogenous antagonist of glycine transporter-I (GlyT-I)…
- Trial name
- NCT01031927
- Testing
- N-methyl glycine
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Skin-Picking
Skin Picking Approach Avoidance Task
Pathological skin picking (PSP) is conceptualized as a behavioral addiction. Research has shown that behavioral addictions (e.g., problematic alcoholism or smoking) can be reduced using a cognitive retraining tool called…
- Trial name
- SPAAT (NCT04099537)
- Testing
- Computerized cognitive training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Wisconsin, Milwaukee
OCD
The Imaging Genetic Study of the Core Family of Obsessive-compulsive Disorder (OCD) Patient
To investigate the structural/functional abnormalities and the possible genetic endophenotypes of Obsessive-compulsive disorder (OCD) patients and their core families.
- Trial name
- NCT01298622
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kunming Medical University
Obsessive-Compulsive Disorder in Children
Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children
This study aims to examine the effects of a game-like program called cognitive control training (CT) for children with obsessive compulsive disorder (OCD).
- Trial name
- NCT06102941
- Testing
- Cognitive Control Training (CT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Obsessive Compulsive Disorder (OCD)
Long-term Follow-up in Patients With Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD).
For this human research, 17 treatment-refractory OCD patients who already received DBS implants for treatment refractory OCD between June 1998 and October 2007 will be included.
- Trial name
- NCT01879254
- Testing
- Deep Brain Stimulation
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obsessive Compulsive Disorder
Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)
This study will address questions of fundamental clinical significance including: (1) whether OCD patients maintained on long term SRIs can be discontinued without symptom exacerbation, (2) whether trans-diagnostic…
- Trial name
- NCT02103621
- Testing
- Unified Protocol (UP), Taper and Monitoring (TAP-M)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Butler Hospital
Obsessive Compulsive Disorder
Addition of Quetiapine in Obsessive Compulsive Disorder - Westenberg Study
Quetiapine (Seroquel ®), an atypical antipsychotic registered for use in schizophrenia, which has a very low propensity of extrapyramidal and endocrine side-effects, has also been studied as an adjunct in OCD.
- Trial name
- NCT00318539
- Testing
- Quetiapine
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- AstraZeneca
Autoimmune Disease, Mental Disorder
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Bacteria carry substances on their surface called antigens. When antigens come into contact with the right kinds of cells in the body an immune reaction is caused.
- Conditions
- Autoimmune Disease, Mental Disorder, Obsessive Compulsive Disorder, Streptococcal Infection
- Trial name
- NCT00001658
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder
Evaluating Unilateral Deep Brain Stimulation in Patients With Obsessive Compulsive Disorder
The investigators previously showed that deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BNST) reduces symptoms in patients with severe obsessive-compulsive disorder (OCD).
- Trial name
- NCT03894397
- Testing
- Electrical stimulation of the BNST
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- KU Leuven
Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD
ERP to Improve Functioning in Veterans With OCD
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no…
- Trial name
- NCT05240924
- Testing
- Exposure and Response Prevention, Stress Management Training
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development