Clinical trials: Obesity and Type 2 Diabetes
Obesity or Overweight
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with…
- Trial name
- Enith1 (NCT07351045)
- Testing
- Enicepatide
- Where
- 209 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Hoffmann-La Roche
Obesity, Type 2 Diabetes
Magnetic Gastro-Ileal or Gastro-Jejunal Diversion Study ("MGI/MGJ Study")
The purpose of this clinical research study is to evaluate the feasibility of the GT Metabolic Solutions Magnet System, GJ Biofragmentable ("MagGJ System") for creation of a side-to-side anastomosis for gastro-ileal or…
- Trial name
- NCT06073457
- Testing
- MagGJ System
- Where
- 4 sites in Canada, Chile and 2 more
- Volunteers
- 35 people
- Sponsor
- GT Metabolic Solutions, Inc.
Type2 Diabetes Mellitus, Obesity
The Metabolic Impact of Bariatric Surgery Compared to Best Diabetic Care on Manitoba's Urban Indigenous Population
Obesity and type 2 diabetes mellitus (T2DM) are major global health concerns as they commonly co-occur and are associated with significant morbidity, mortality, and health care expenditures.
- Conditions
- Type2 Diabetes Mellitus, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03301545
- Testing
- Fast-Track to Bariatric Surgery
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Obesity, Insulin Sensitivity/Resistance
Energy -Sensing Metabolites in Caloric Restriction
General integrated goal of the coordinated project: To elucidate the role of succinate and other metabolites derived from the intestinal microbiota such as Short Chain Fatty Acids (SCFAs), as energy sensing metabolites in the…
- Conditions
- Obesity, Insulin Sensitivity/Resistance, Diabetes Type 2
- Trial name
- NCT05031572
- Testing
- dietary intervention
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Obesity
A 1-Year Study On The Effects Of CP-945,598 For The Treatment Of Obesity In Overweight Type 2 Diabetic Patients
The purpose of this study is to determine if CP-945,598 is effective in the treatment of obesity in type 2 diabetic patients.
- Trial name
- NCT00391196
- Testing
- CP-945,598, CP-945,598 Treatment B
- Where
- 91 sites in United States, Argentina and 9 more
- Volunteers
- 975 people
- Sponsor
- Pfizer
Type 2 Diabetes, Diabetes Type 2
Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
The current protocol plans to enroll participants with youth-onset Type 2 Diabetes (T2D) as well as obese and lean controls from the Renal-HEIR - Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2…
- Conditions
- Type 2 Diabetes, Diabetes Type 2, Diabetic Nephropathies, Nephropathy
- Trial name
- HEIRitage (NCT05530356)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Obesity, Type 2 Diabetes
Video Games for Obesity and Diabetes Prevention-Diab & Nano
With the increasing rates of child obesity and diabetes, innovative programs are needed that capture children's attention and permit behavior change messages to get through.
- Trial name
- G4H-DiabNano (NCT01846377)
- Testing
- G4H-Diab-Nano
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Childhood Obesity
Type 2 Diabetes Prevention Toolkit for Health-Care Professionals
Tools are limited to help health care professionals talk about weight-related issues with their pediatric patients. The investigators have developed 6 whiteboard videos for health care professionals based on the 5As of Pediatric…
- Trial name
- NCT04126291
- Testing
- Evaluation of whiteboard videos
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Type 2 Diabetes, PreDiabetes
Butyrate-enriched Triglyceride and Diabetes Prevention
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT06384313
- Testing
- butyrate/hexanoate-enriched triglycerides
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Type 2, Obesity
Does Green Tea Affect Postprandial Glucose, Insulin and Satiety in Healthy Subjects
Green tea consumption could lower the risk of type II diabetes, as suggested by epidemiological studies. There is also evidence from intervention studies that green tea can decrease blood glucose levels and contribute to weight…
- Trial name
- NCT01086189
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases
Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD
To evaluate the relationship of baseline toenail chromium concentrations to weight loss, as well as the interaction between heavy metals and the beneficial effects of weight loss.
- Conditions
- Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases, Obesity, Myocardial Infarction
- Trial name
- NCT00031213
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes
Efficacy of Once Weekly Semaglutide in Patients With Type 2 Diabetes: a Non Randomized Clinical Trial
A single arm no randomized clinical trial evaluated the effectiveness and safety of once weekly semaglutide in adults with type 2 diabetes militus and obesity whose glycemic control remained inadequate despite standard therapy.
- Trial name
- NCT07732218
- Testing
- Semaglutide (Ozempic®)
- Where
- Pakistan
- Volunteers
- 95 people
- Sponsor
- Rehman Medical Institute - RMI
Type 2 Diabetes Mellitus, Obesity
Effects of Rosiglitazone on Bone in Postmenopausal Diabetic Women
The purpose of this study is to evaluate the effect of rosiglitazone on bone metabolism and to assess the association between the changes in bone turnover parameters and plasma cytokine levels in postmenopausal diabetic women
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Menopause
- Trial name
- NCT00440375
- Testing
- Rosiglitazone
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Baskent University
Type2 Diabetes, Obesity
Probiotic Supplementation and Pancreatic β-Cell Function in Type 2 Diabetes
Probiotics have beneficial effect on obesity related disorders in animal models. Current understanding for the beneficial effects of probiotics in type 2 diabetes strictly relies on animal and clinical data, which mainly focus on…
- Conditions
- Type2 Diabetes, Obesity, Insulin Resistance, Obesity, Abdominal
- Trial name
- NCT05765292
- Testing
- Probiotic
- Where
- 4 sites in Ukraine
- Volunteers
- 68 people
- Sponsor
- Bogomolets National Medical University
Obesity, Diabetes
Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes
Quercetin is a compound naturally found in various foods. It may have some role in the treatment of obesity and diabetes. The purpose of this study is to investigate research volunteers with obesity or obesity with type 2…
- Trial name
- NCT00065676
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 2
A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes
This study is designed to evaluate the dose range for MEDI0382 with respect to blood glucose control and weight loss effects, as well as to further explore the safety profile of MEDI0382
- Trial name
- NCT03235050
- Testing
- MEDI0382 low dose, MEDI0382 mid dose, MEDI0382 high dose
- Where
- 119 sites in United States, Bulgaria and 6 more
- Volunteers
- 834 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Obesity
Endoscopic Sutured Gastroplasty with Endomina® Device Versus Standard of Care in Patients with Type 2 Diabetes and Class I Obesity: a Multi-center, Randomized Controlled Trial
The primary objective of this study is to assess the efficacy of endoscopic gastric reduction with the endomina® device, in combination with standard of care, compared to standard of care alone, on the remission of diabetes 24…
- Trial name
- ESTIME (NCT05516576)
- Testing
- endomina®
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Colon Cancer
Screening and Risk Factors of Colon Neoplasia
The investigators propose a screening population-based study to systematically evaluate the accuracy and clinical relevance of sDNA testing as a potential alternative to colonoscopy screening.
- Trial name
- NCT01647776
- Testing
- Stool DNA Test, biopsies of rectal and colon mucosa, Questionnaires
- Where
- United States
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Type 2 Diabetes, Obesity
Improving Diabetes Outcomes Through Lifestyle Change (IDOLc)Study
This research project has two primary specific aims in the Partners HealthCare clinical population and setting: 1. To compare the effects of two interventions, a translation of the Look AHEAD lifestyle behavioral intervention…
- Trial name
- IDOLc (NCT01665989)
- Testing
- Group Lifestyle Program, Usual Care
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.