Clinical trials: Obesity and Overweight
Obesity
Effects of Consuming Protein Shakes, Varying in Protein Source, on Appetite, Satiety and Energy Intake
Background: Consistent data from acute, single preload studies demonstrate improvements in perceived appetite and satiety following the consumption of high-protein preloads compared to normal protein preloads.
- Trial name
- NCT03132376
- Testing
- Water Preload Drink, Whey Protein Isolate Drink, Micellar Casein Protein Drink
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Purdue University
Obesity, Lifestyle, Healthy
Twelve-year Follow-up on the Treatment of Obese Pregnant Women (TOP) Study
The participant (both mother and child) in the initial TOP study will be invited to a follow-up study to evaluate the effect of life style intervention during pregnancy on both mother and their offspring 12 years after the…
- Conditions
- Obesity, Lifestyle, Healthy, Diet, Healthy, Follow-up
- Trial name
- TOP12 (NCT05446220)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Overweight and Obesity
Safety, Tolerability and Pharmacokinetic Characteristics Evaluation of DA-302168S Tablets
To Evaluate the Safety, Tolerability and Pharmacokinetics on DA-302168S Tablets in Randomized, Double-blind, Placebo-controlled Single-dose and Multiple-dose ascending Phase I Clinical Trials in Healthy Subjects.
- Trial name
- DA168 (NCT06534320)
- Testing
- DA-302168S
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chendu DIAO Pharmaceutical Group CO., LTD.
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Obesity
Sports to Prevent Obesity: Feasibility and Pilot RCT
The purpose of this study is to learn whether overweight children who participate in an after school sports program improve their health as much as overweight children in a more traditional health education program.
- Trial name
- NCT00186173
- Testing
- After school sports program, After school health education
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity
Metformin Versus Orlistat in Obese Polycystic Ovary Syndrome (PCOS) Patients
The purpose of this study is to compare the influence of Orlistat and Metformin on obesity treatment in obese PCOS women.
- Trial name
- NCT01003483
- Testing
- orlistat
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Arrhythmia, Sudden Cardiac Death
Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
Obesity, rheumatoid arthritis (RA) and gene-specific dilated cardiomyopathy (DCM) are common medical conditions. Small-scale studies have shown that these are associated with proarrhythmic changes on 12-lead electrocardiogram…
- Conditions
- Arrhythmia, Sudden Cardiac Death, Cardiomyopathy, Dilated, Obesity
- Trial name
- EPORVA (NCT03910725)
- Testing
- Electrocardiographic imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Endotoxemia
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
This study is focused on assessing gastrointestinal-level improvements by which green tea limits metabolic endotoxemia. It is completed in two phases.
- Conditions
- Obesity, Endotoxemia, Inflammation
- Trial name
- NCT03413735
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Obesity
Remote Intervention for Weight Regain After Sleeve Gastrectomy
The study is designed to assess the effect of a 3-month remote comprehensive intervention program by a multidisciplinary team combined with mobile supportive text messages aimed to raise the level of happiness and subjective…
- Trial name
- NCT05122013
- Testing
- A comprehensive remote multidisciplinary intervention for weight regain after sleeve gastrectomy, Control group
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Obesity
The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism
This study will determine the effects of supplementing beta-hydroxy-beta-methylbutyrate (HMB) on body composition and strength changes during weight loss.
- Trial name
- NCT02717013
- Testing
- HMB
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.
Obesity, Overweight
Mobile Attention Retraining in Overweight Female Adolescents
Background: People are constantly exposed to unhealthy foods. Some studies of adults show that training attention away from unhealthy foods might reduce overeating.
- Conditions
- Obesity, Overweight, Binge Eating, Healthy Volunteers
- Trial name
- NCT02977403
- Testing
- Attention Bias Retraining
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy, Obese
PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction
Obesity and its adverse cardiometabolic consequences are major public health problems. Several features of obesity contribute to the associated cardiovascular risk and are potential targets for intervention.
- Trial name
- NCT02819440
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Overweight and Obesity, Risk Reduction
Healthy Lifestyle Intervention on Diabetes Risk Reduction Among Bruneian Young Adults
The general research question posed was 'How effective is a healthy lifestyle intervention using behavioural change strategies in the prevention of Type 2 Diabetes Mellitus (T2DM)?'.
- Conditions
- Overweight and Obesity, Risk Reduction, Diabetes Mellitus, Type 2
- Trial name
- NCT04217759
- Testing
- Healthy lifestyle intervention
- Where
- Brunei
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Universiti Brunei Darussalam
Infant, Obesity
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) Study
This study will test an intervention program designed to provide developmentally appropriate guidance to parents of infants on responsive parenting and healthy lifestyle to see if that intervention will prevent rapid weight gain…
- Trial name
- INSIGHT (NCT01167270)
- Testing
- Child Safety Insights, Parenting Insights
- Where
- 2 sites in United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Ian M. Paul, MD
Fluconazole, Candidiasis
Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration
The pharmacokinetics of fluconazole are expected to be different in obese patients compared to non-obese patients. The investigators will determine fluconazole and free fluconazole concentrations in 16 obese patients and 8…
- Conditions
- Fluconazole, Candidiasis, Invasive Fungal Infections, Obesity
- Trial name
- FOLIA (NCT04122560)
- Testing
- Fluconazole 200mg tab, Fluconazole 2 MG/ML
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bariatric Surgery, Bone Health
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population.
- Conditions
- Bariatric Surgery, Bone Health, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- BODI (NCT03455868)
- Testing
- Bariatric surgery
- Where
- 3 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Obesity, Type 2 Diabetes Mellitus
Gut Microbiota in Obesity and Diabetes
An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals.
- Trial name
- NCT02180191
- Testing
- Comparison of the gut microbiota composition
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Obesity, Diabetes
Hypothalamic Function Before and After Bariatric Surgery
The purpose of this study is to determine the effect of gastric banding or gastric bypass on hypothalamic morphology and function, gut hormones and systems biology in obese subjects with and without type 2 diabetes.
- Trial name
- NCT01167959
- Testing
- Roux en Y gastric bypass and lap. gastric banding, Prodimed dietary intervention
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Migraine, Obesity
Behavioral Weight Loss as a Treatment for Migraine in Obese Women
This study involves a randomized controlled trial to test the efficacy of behavioral weight loss as a treatment for migraine in obese females aged 18 to 50 years.
- Trial name
- NCT01197196
- Testing
- Behavioral Weight Loss Intervention, Migraine Education
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Obesity
Nighttime Protein Intake on Overnight Lipolysis and Morning Fat Oxidation in Obese Men
Single macronutrients will be consumed before sleep by obese men. Overnight lipolysis will be measured with the microdialysis technique by measuring glycerol concentration and blood flow in abdominal adipose tissue.
- Trial name
- NCT02211391
- Testing
- Casein Protein
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University
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