Clinical trials: Obesity and Cardiovascular Risk
HIV Infections, Cardiovascular Disease
Myocardial Function & FFA Metabolism in HIV Metabolic Syndrome
We hypothesize that the hearts of HIV+ people with The Metabolic Syndrome use and oxidize fats and sugars inappropriately, and that this may impair the heart's ability to pump blood.
- Conditions
- HIV Infections, Cardiovascular Disease, Insulin Resistance, HIV Lipodystrophy
- Trial name
- WU197 (NCT00656851)
- Testing
- Pioglitazone, Exercise Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Disease (CVD), Hypertension
Veteran Peer Coaches Optimizing and Advancing Cardiac Health
The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor.
- Conditions
- Cardiovascular Disease (CVD), Hypertension, Hyperlipemia, Obesity
- Trial name
- Vet-COACH (NCT02697422)
- Testing
- Community-based peer health coach intervention
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Obesity
Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk Factors
Web- or internet-based programs have the potential to induce and, possibly, help to sustain, significant lifestyle modification.
- Trial name
- NCT01472276
- Testing
- Web-based program
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Visceral, Cardiovascular Diseases
Impact of Liraglutide 3.0 on Body Fat Distribution
This study is a clinical study to investigate the efficacy of liraglutide compared to placebo in reducing visceral adiposity measured by MRI in overweight or obese subjects at high risk for cardiovascular disease after 40 weeks…
- Conditions
- Obesity, Visceral, Cardiovascular Diseases, Fat Disorder
- Trial name
- NCT03038620
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Overweight and Obesity, PreDiabetes
Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study
The overall goal is to determine the real-world feasibility and utility of body fat imaging using rapid MRI to enhance risk perception, induce behavioral change, and improve clinical outcomes in overweight and obese individuals.
- Conditions
- Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
- Trial name
- BODY-REAL (NCT04763772)
- Testing
- Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University Hospitals Cleveland Medical Center
Pregnancy Related, Cardiovascular Risk Factor
Promoting Stretching Exercise to Reduce Cardiovascular Health Risk in Late Pregnant Women With Obesity
The purpose of this trial is to determine whether a stretching intervention is superior to a usual care control condition (moderate/vigorous activity 30 minutes daily, 5 days per week) for pregnant women from 27 to 37 gestational…
- Conditions
- Pregnancy Related, Cardiovascular Risk Factor, Obesity
- Trial name
- NCT04291560
- Testing
- Stretching Exercise Intervention
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of North Carolina, Chapel Hill
Sleep Apnea Syndromes
Effects of CPAP on Diet, Physical Activity, and Cardiovascular Risk
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete loss of airflow during sleep, due to narrowing or closure of the upper airway.
- Trial name
- NCT01944020
- Testing
- CPAP
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Cardiovascular Disease, High Cardiovascular Risk
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
- Conditions
- Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight
- Trial name
- CAMELLIA-TIMI (NCT02019264)
- Testing
- Lorcaserin hydrochloride
- Where
- 499 sites in United States, Australia and 6 more
- Volunteers
- 14,673 people
- Sponsor
- Eisai Inc.
Cardiovascular Risk Factor, Cardiovascular Diseases
Substituting Sitting With Standing and Walking in Free-living Conditions Improves Daily Glucose Profile in South Asians
The purpose of this study is to investigate the effects of substituting sitting under free-living conditions in South Asian adults with overweight and obesity on continuous glucose profiles.
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Diabetes, Type 2 Diabetes
- Trial name
- NCT04645875
- Testing
- SIT regimen, SITless regimen
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Type 2 Diabetic Male With Hypogonadotrophic Hypogonadism
Effect of Androgel on Atherogenesis in Type 2 Diabetic Males With Hypogonadotrophic Hypogonadism
The purpose of this study is to examine the effects of testosterone deficiency in men with diabetes on atherogenesis, inflammation, cardiovascular Risk factors And adiposity .
- Trial name
- NCT00467987
- Testing
- androgel
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Cardiovascular Diseases, Diabetes Mellitus
Evaluation of a Letter Intervention Promoting a Plant-based Diet
The researchers' mission is to promote healthier eating behavior and to reduce costs associated with healthcare. The purpose of this study is to evaluate the effects of mailing randomly selected participants a letter promoting a…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Obesity
- Trial name
- NCT03880838
- Testing
- Personal testimonial, Forks Over Knives Documentary, Commitment nudge
- Where
- United States
- Volunteers
- 11,234 people
- Sponsor
- Geisinger Clinic
Hypertension, Cardiovascular Diseases
Cardiovascular Disease Risk Factors in Chinese American Immigrants
The Chinese population is currently the fastest growing ethnic group in New York City (NYC). Research has shown that Chinese immigrants living in NYC have higher rates of cardiovascular disease (CVD) than individuals in China.
- Conditions
- Hypertension, Cardiovascular Diseases, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- CHA-CHA (NCT00362128)
- Where
- United States
- Volunteers
- 2,072 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Obesity
Effect of Vitamin D3 Supplementation on Insulin Resistance and Cardiovascular Risk Factors in Obese Adolescents
The prevalence of obesity has reached epidemic proportions nationally as well as internationally. Currently, 16 % of American adolescents are obese.
- Trial name
- NCT00858247
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity
A Long Term Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients
The purpose of the study was to determine the long-term effect of sibutramine treatment on cardiovascular outcomes in overweight and obese patients at risk of a cardiovascular event.
- Trial name
- SCOUT (NCT00234832)
- Testing
- Sibutramine hydrochloride
- Where
- United States
- Volunteers
- 10,777 people
- Sponsor
- Abbott
Polycystic Ovary Syndrome (PCOS), Overweight
The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS
Polycystic ovary syndrome (PCOS) is a health problem that affects one in 10 women of childbearing age, which is usually characterized by hormonal imbalance and metabolism problems such as hyperandrogenism and obesity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Overweight, Obesity
- Trial name
- NCT03151005
- Testing
- Metformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xinqiao Hospital of Chongqing
Type 1 Diabetes, Obesity
ADJUnct Semaglutide Treatment in Type 1 Diabetes
The purpose of this study is to assess the use of once weekly semaglutide injection in inadequately controlled obese adults with type 1 diabetes (T1D) using FDA-approved hybrid closed-loop therapies.
- Trial name
- ADJUST-T1D (NCT05537233)
- Testing
- Semaglutide
- Where
- 4 sites in United States
- Volunteers
- 115 people
- Sponsor
- Viral N. Shah
Obesity, Cardiovascular Risk Factor
Visualizing Vascular Mechanisms of Salt Sensitivity
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
- Conditions
- Obesity, Cardiovascular Risk Factor, Salt; Excess
- Trial name
- NCT03696433
- Testing
- Low-salt diet, High-salt diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cardiovascular Diseases, Cardiovascular Risk Factor
Cooking for Health Optimization With Patients
Cooking for Health Optimization with Patients (CHOP) is the first known multi-site prospective cohort study with a nested Bayesian adaptive randomized trial in the preventive cardiology field of culinary medicine.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Nutrition Disorders, Diabetes
- Trial name
- CHOP (NCT03443635)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 7,192 people, healthy volunteers welcome
- Sponsor
- Tulane University