Clinical trials: Obesity, Morbid, open to volunteers
Morbid Obesity, Obesity
TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass
This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity.
- Trial name
- TSBL-OAGB (NCT07796503)
- Testing
- TSBL-based biliopancreatic limb length determination, BMI-based biliopancreatic limb length determination
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Scientific Center of Surgery named after A.N.Syzganov
Postoperative Nausea and Vomiting, Postoperative Pain
Postoperative Nausea, Vomiting and Pain After Bariatric Surgery - a National Registry Study
Around 4,000-5,000 bariatric (weight-loss) operations are performed in Sweden every year. Nausea, vomiting and pain are common immediately after these operations, cause considerable suffering and increase the intensity and length…
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Obesity, Morbid, Bariatric Surgery
- Trial name
- BAROSPOR (NCT07797374)
- Where
- 2 sites in Sweden
- Volunteers
- 30,000 people
- Sponsor
- Umeå University
Obesity Difficult Airway Airway Management
Videolaryngoscopes in the Morbidly Obese
This study will evaluate four videolaryngoscopes used for intubation of extremely obese (class 3 obesity) patients scheduled for bariatric surgery.
- Trial name
- NCT07787468
- Testing
- Airway management
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Uniwersytet Radomski im. Kazimierza Pułaskiego
Pain, Back, Obesity, Morbid
Brown Adipose Tissue Activation by Spinal Cord Stimulation
The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing…
- Conditions
- Pain, Back, Obesity, Morbid, Type 2 Diabetes
- Trial name
- NCT04326192
- Testing
- Research electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Severe Obesity, Morbid Obesity Requiring Bariatric Surgery
Early Discharge With Hospital-at-Home After Bariatric Surgery and Economic Evaluation.
Bariatric surgery is the most effective treatment for severe obesity and its associated diseases. Advances in surgical techniques, enhanced recovery protocols, and multimodal perioperative care have made earlier hospital…
- Trial name
- BEHOME (NCT07782281)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Corporacion Parc Tauli
Obesity
Longitudinal Study of the Psychological Impact of Bariatric Surgery
This prospective observational study evaluates the effect of bariatric surgery on mental health and hair cortisol in patients with morbid obesity over a 3-year follow-up.
- Trial name
- BARI-SCL (NCT07780058)
- Where
- 2 sites in Spain
- Volunteers
- 70 people
- Sponsor
- University of Alicante
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lamotrigine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497143
- Testing
- Lamotrigine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Losartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03519893
- Testing
- Losartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Metoprolol
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03519906
- Testing
- Metoprolol
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Valsartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03535376
- Testing
- Valsartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Paracetamol
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03538457
- Testing
- Paracetamol
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid, Extubation Failure
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing.
- Trial name
- NCT05918575
- Testing
- Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula
- Where
- 5 sites in United States, Mexico
- Volunteers
- 250 people
- Sponsor
- Rush University Medical Center
Obesity, Morbid, Obesity; Endocrine
Impact of MBS on Body Composition, Basal Metabolic Rates and Muscle Functions in Morbid Obese Patients
PRIMARY OBJECTIVE To evaluate the changes in body composition in morbid obese patients following bariatric and metabolic surgery Secondary Objectives: 1. To assess changes in BMR in obese patients following bariatric surgery 2.
- Conditions
- Obesity, Morbid, Obesity; Endocrine, Fat Disorder
- Trial name
- BARCOM (NCT07737860)
- Volunteers
- 21 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Morbid Obesity, Pregnancy
Induction of Labor in Morbidly Obese Patients
The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI >40.
- Trial name
- NCT06199154
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Maryland, Baltimore
Obesity, Morbid
Investigating Metabolic, Brain, and Cognitive Alterations Through Bariatric Surgery
Despite global efforts, the prevalence of obesity continues to rise, with rates in Canada tripling over the past three decades. In addition to the well-established risk of cardiometabolic conditions such as heart disease and…
- Trial name
- BRAINS (NCT07704229)
- Testing
- Sleeve Gastrectomy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Ramipril
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03440177
- Testing
- Ramipril
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Apixaban
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03448783
- Testing
- Apixaban
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Quetiapine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03449472
- Testing
- Quetiapine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Chlorprothixene
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03449485
- Testing
- Chlorprothixene
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Candesartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03460327
- Testing
- Candesartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology