Clinical trials: OSA - Obstructive Sleep Apnea
Pulmonary Arterial Hypertension, Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) in Pulmonary Arterial Hypertension (PAH)
The purpose of this study is to determine whether pulmonary arterial hypertension can worsen or even cause sleep apnea. It is hypothesized that if pulmonary arterial hypertension does indeed worsen or cause sleep apnea, then the…
- Trial name
- NCT01835080
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Obstructive Sleep Apnea
Upper Airway Stimulation Versus Continuous Positive Airway Pressure
Standard therapy in patients with obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). 30% to 50% are not adherent to this therapy and need an alternative treatment.
- Trial name
- NCT03756805
- Testing
- upper airway stimulation, continuous positive airway pressure
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Technical University of Munich
OSA - Obstructive Sleep Apnea
Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping
Insomnia and obstructive sleep apnoea (OSA) are very common conditions, collectively estimated to affect 2 billion people globally, and share many of the same symptoms.
- Trial name
- ELOSA (NCT06928766)
- Testing
- Eszopiclone 3 mg, Lemborexant 10mg
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Flinders University
Melanoma With a Breslow's Thickness ≥ 1mm, Obstructive Sleep Apnea Syndrome
Impact of Obstructive SAS on Metastatic Potential of Cutaneous Melanoma
Hypothesis: to address if diagnosis of obstructive sleep apnea before or during the extending check-up is a risk factor toward metastasis for melanoma stage ≥ tIIaN0M0 Study design: Adult patients with a Breslow's Thickness ≥ 1mm…
- Trial name
- MELA-SAS (NCT02699918)
- Testing
- nocturnal oximetry
- Where
- France
- Sponsor
- AGIR à Dom
Overlap Syndrome
Auto-trilevel Ventilator for Patients With Overlap Syndrome
Obstructive Sleep Apnea Syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist and are called overlap syndrome(OS).
- Trial name
- NCT01523197
- Testing
- BiPAP ventilation, auto-trilevel ventilation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Nanjing Medical University
OSA - Obstructive Sleep Apnea
The Optimal One-Month Dosing of Lemborexant for Moderate Obstructive Sleep Apnea (OSA) Patients With Low Arousal Threshold
The goal of this clinical trial is to investigate the 1-month treatment effects of different dose of lemborexant in moderate OSA adult patients (18-65 years of age) with low arousal threshold.
- Trial name
- LMOSALAT (NCT07683442)
- Testing
- Lemborexant 5 MG [Dayvigo] Period 1, Lemborexant 5 MG [Dayvigo] Period 2, Lemborexant 5 MG [Dayvigo] Period 3
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Chulalongkorn University
Obstructive Sleep Apnea (OSA)
Development of Advanced Leak Detection Technologies for Positive Airway Pressure Devices Therapies
This study will take between 1-2 months (with first patient first visit to last patient last visit). Each participant will use the supplied PAP device and mask for a period of up to 14 nights.
- Trial name
- NCT04741854
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ResMed
Sleep-Disordered Breathing, Sleep Architecture
Validation of Belun Ring Gen3 Deep Learning Algorithms With Subxiphoid Body Sensor
Hypothesis: BR's Gen3 DL algorithms, combined with its subxiphoid body sensor, can accurately diagnose OSA, categorize its severity, identify REM OSA and supine OSA, and detect central sleep apnea (CSA).
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Arrhythmia
- Trial name
- NCT06255613
- Testing
- Belun Ring, Belun Cor
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Belun Technology Company Limited
Obstructive Sleep Apnoea, Pregnancy
STOPBANG As A Screening Tool for Obstructive Sleep Apnoea in Pregnancy
This study evaluates the use of the STOPBANG questionnaire to predict whether a pregnant woman with class III obesity has obstructive sleep apnoea.
- Trial name
- NCT02542488
- Testing
- STOPBANG Questionnaire, Overnight pulse oximetry, Epworth Sleepiness Scale
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- City Hospitals Sunderland NHS Foundation Trust
Obstructive Sleep Apnea (OSA)
Level 3 Validation Study
This study will compare the output of a new Level 3 polysomnography system against in-laboratory polysomnography.
- Trial name
- NCT07688603
- Testing
- Comparison 1: Level 1 Polysomnography: Cadwell/Alice, Comparison 2: Level 3 Test: Berry Sleep Apnea Screening Monitor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Obstructive Sleep Apnea Syndrome
The Effect of Intubation Without Muscle Relaxation on Post Operative Recovery Conditions: Double Blind Randomized Controlled Study
The primary aim of this study is to research the effect of intubation without muscle relaxant on post-operative recovery conditions in patients with OSAS (obstructive sleep apnea syndrome).
- Trial name
- NCT03824470
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Apnea, Sleep Apnea Syndromes
Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients
This study compares the titration pressures achieved through two auto-titrating modalities, a new incremental fixed pressure mode versus routine auto-adjusting pressure mode, in CPAP-naïve obstructive sleep apnea patients.
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Disordered Breathing
- Trial name
- NCT03734341
- Testing
- EZ START Titration, APAP Titration
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Basque Health Service
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA.
- Trial name
- NCT01033266
- Testing
- CPET
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
Hypertension, Obstructive Sleep Apnea
Nocturnal Hypertension and Non-Dipping Blood Pressure
The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels.
- Trial name
- NCT03128177
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obstructive Sleep Apnea
First Line Obstructive Sleep Apnea Treatment Study
The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed…
- Trial name
- FLOSAT (NCT05393531)
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Peer-Driven Intervention for Sleep Apnea
Fragmentation of care can lead to poor treatment adherence in patients with chronic medical conditions which can, in turn, lead to adverse health consequences, poor quality of life, and patient dissatisfaction.
- Trial name
- PCORI (NCT02056002)
- Testing
- Usual Care, Peer-Buddy System
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Arizona
Obstructive Sleep Apnea Syndrome
PADN to Treat Severe Obstructive Sleep Apnea
This project is focused on the treatment of severe obstructive sleep apnea with pulmonary artery denervation (PADN). Although it has now been proved that continuous positive airway pressure (CPAP) is the primary treatment for…
- Trial name
- PADN-OSA (NCT02687477)
- Testing
- Pulmonary Arterial Denervation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Obstructive Sleep Apnea
Vitamin D Levels and Heart Rate Variability on Endothelial Function Via RAAS Augmentation in OSA
The role of obstructive sleep apnea (OSA) in contributing to hyperaldosteronism, which can lead to increased morbidity and mortality, is less well-established.
- Trial name
- RAAS_OSA (NCT05232201)
- Where
- Malaysia
- Volunteers
- 150 people
- Sponsor
- University Malaysia Sarawak
Obstructive Sleep Apnea of Adult, Positive Airway Pressure
Effect of Smart Watch and App on PAP Adherence in OSA (Watch-OSA)
Continuous positive airway pressure (CPAP) is highly effective in treating obstructive sleep apnea (OSA). However, this treatment modality relies heavily on patient adherence, and poor adherence to the treatment limits its…
- Conditions
- Obstructive Sleep Apnea of Adult, Positive Airway Pressure, Adherence, Treatment, Smart Watch
- Trial name
- NCT05530265
- Testing
- the smart watch and Samsung Health app
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital