Clinical trials: OSA - Obstructive Sleep Apnea
Weight Management
A Study of HRS9531 Injection in Obese Subjects With Obstructive Sleep Apnea
The purpose of this study is to evaluate the effect and safety of HRS9531 Injection in Obese Subjects with Obstructive Sleep Apnea
- Trial name
- NCT06565871
- Testing
- HRS9531 Injection
- Volunteers
- 108 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Sleep Apnea
Influence of Didgeridoo Practice on UA Obstruction Levels in Moderate OSA
Didgeridoo practice has been shown to improve OSA severity. The aim of our study is to assess the changes in upper airways obstruction levels before and after Didgeridoo practice in moderate OSA patients.
- Trial name
- NCT02159664
- Testing
- didgeridoo practice
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
OSA
Ambulatory Versus Conventional Approach Diagnosing OSA
Very few studies have examined different models of care involving initial ambulatory home-based diagnosis in diagnosing obstructive sleep apnea (OSA), identifying patients who benefit from continuous positive airway pressure…
- Trial name
- NCT01828216
- Testing
- Home sleep study, conventional polysomnography
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients
Obstructive sleep apnea (OSA) is a type of disordered breathing defined by the repetitive obstruction of airflow during sleep due to upper airway collapse. Each obstructive event contributes to decreased blood oxygen, or hypoxia.
- Trial name
- NCT05387122
- Testing
- mandibular advancement device (MAD)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea of Adult
Efficacy of Oropharyngeal Exercises for Patients With Obstructive Sleep Apnea Using Mandibular Advancement Device
Combined treatment with MAD and OE for adult patients with obstructive sleep apnea can significantly (i) improve muscle strength and endurance; (ii) reduce the severity of sleep apnea.
- Trial name
- NCT05717959
- Testing
- Oropharyngeal Exercises
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Obstructive Sleep Apnea of Adult
Pilot Study of the MultiSense Patch to Record Cardiopulmonary Data During Sleep and Wake Cycles
The investigators are proposing to use a wearable device, MultiSenseTM, developed by Rhythm Diagnostic Systems, Inc. which has many sensors inside in a "Band-Aid" like strip in order to see if it can help diagnose capabilities in…
- Trial name
- NCT02222103
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Ischemic Stroke, Sleep Apnea Syndrome
Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke
Ischemic stroke is a kind of common disease with great harm. In acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome.
- Trial name
- SAHS (NCT02029183)
- Testing
- Bi level positive pressure ventilation, bi-level positive airway pressure
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Obstructive Sleep Apnea
PAP Therapy Sleep Apnea and Exercise
Positive airway pressure (PAP) therapy is generally offered to patients with obstructive sleep apnea. The investigators suggest that beneficial effects of PAP therapy is by preventing apneas and therefore reducing cardiac and…
- Trial name
- NCT01786291
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Gaziantep
Obstructive Sleep Apnea
Impact of Polyphenols on Endothelial Function in Obstructive Sleep Apnea
Severe obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Endothelial dysfunction, an early marker of vascular disease has been demonstrated in OSA.
- Trial name
- PolySAS (NCT01977924)
- Testing
- one month polyphenols supplementation (600mg)
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Obesity, Obesity, Maternal
Obesity and OSA in Pregnancy
The purposes of this project are 1) to compare the impact of maternal obesity versus excessive gestational weight gain on obstructive sleep apnea (OSA) in obese and non-obese women; 2) to investigate the mechanism(s) by which…
- Conditions
- Obesity, Obesity, Maternal, Obstructive Sleep Apnea, Blood Pressure
- Trial name
- NCT05654259
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Texas Southwestern Medical Center
Obstructive Sleep Apnea (OSA), Ischemic Optic Neuropathy/Optic Nerve Stroke
Optic Nerve Injury in Obstructive Sleep Apnea Patients
Ischemic optic neuropathy (ION) is damage to the optic nerve caused by ischemia and hypoxia of the optic nerve due to an impairment of the blood supply to the optic nerve from the arteries.
- Trial name
- NCT06748703
- Testing
- CPAP Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Medical University
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnea
Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea
The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea.
- Trial name
- NCT00956423
- Testing
- moderate-intensity aerobic and resistance training, low-intensity stretching
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obstructive Sleep Apnea
Metabolomics of Obstructive Sleep Apnea
This is an R01 funded project that focuses on the utility of metabolomics as a biomarker for OSA. Aims 1 and 3 leverages banked samples previously collected from subjects with and without OSA at the University of Pennsylvania and…
- Trial name
- MOSA (NCT04572269)
- Testing
- No Intervention
- Where
- 2 sites in United States, Iceland
- Volunteers
- 388 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea of Adult, Heart Valve Diseases
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement
Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease.
- Trial name
- NCT03839654
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing Medical University
Atrial Fibrillation, Obstructive Sleep Apnea
OSA Prevalence in Atrial Fibrillation Patients: Jordanian Study
Current Knowledge: Countless studies have been conducted to study the relationship between OSA and AF, and a significant association has been established between both diseases, owing to the numerous shared risk factors and a wide…
- Trial name
- NCT05990010
- Testing
- Berlin Questionnaire
- Where
- Jordan
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Obstructive Sleep Apnea Syndrome, Oropharyngeal Cancer
Obstructive Sleep Apnea Syndrome After Oropharyngeal Cancer Treatment
The level of knowledge about the consequences of oropharyngeal cancer treatment on sleep quality remains poor. Because of a high level of risk of developing an Obstructive Sleep Apnea Syndrome (OSAS), an accurate evaluation of…
- Trial name
- NCT02881723
- Testing
- Surgery, Radio- chemotherapy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obstructive Sleep Apnea Syndrome
Apneic Oxygenation by Transnasal Humidified Rapid Insufflation Ventilator Exchange Obstructive Sleep Apnea Patients
The purpose of the study is to compare effectiveness of different methods of achieving oxygenation in obstructive sleep apnea patients.
- Trial name
- THRIVE (NCT06581588)
- Testing
- THRIVE, THRIVE combine nasopharyngeal airway
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Beijing Tongren Hospital
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06089096
- Testing
- Home Sleep Apnea test (HSAT)
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obstructive Sleep Apnea
Validation of Sleep Healthcare System
The present project aims to that examine the interplay between sleep duration circadian phase, and metabolic regulation. The impact of CPAP therapy on metabolic regulation is assessed with a RCT.
- Trial name
- NCT04252482
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital