Clinical trials: OSA - Obstructive Sleep Apnea
Obstructive Sleep Apnea Syndrome
Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome (OSAS) After Tonsillectomy
The study will evaluate the post-operative morphine-sparing effect, pain reduction, and side effects of a continuous ketamine infusion after tonsillectomy in pediatric patients.
- Trial name
- KOSATA (NCT02425202)
- Testing
- Ketamine, Saline infusion
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obstructive Sleep Apnea
Developement of TipTraQ Home Sleep Test
The clinical study aims to develop and fine-tune the TipTraQ system, created by PranaQ, for home sleep apnea screening. The system comprises a wearable device and a cloud-based AI for estimating Total Sleep Time (TST) and…
- Trial name
- NCT06474351
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- PranaQ Pte. Ltd.
Sleep Apnea, Heart Failure
The Prevalence and Risk Factors of Sleep Disordered Breathing in a Heart Failure Program
The objective of this protocol is the evaluation of our clinical screening program for sleep disorders in patients with heart failure.
- Trial name
- NCT00679822
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Ohio State University
Sleep Apnea, Obstructive
Evaluation of Swallowing in Patients With Obstructive Sleep Apnea
The purpose of this study is to test the hypothesis that obstructive sleep apnea syndrome is associated with deviant pharyngeal swallowing function, using clinical, endoscopical and manometric evaluation.
- Trial name
- NCT01335594
- Testing
- clinical, endoscopical and manometric evaluation
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- Luciana Almeida Moreira da Paz Oliveira
Obstructive Sleep Apnea
The Effectiveness of SensAwake™ for Continue Positive Airway Pressure Treatment of Obstructive Sleep Apnea Patients
This study will investigate Obstructive Sleep Apnea (OSA) and an automatically Adjusting Positive Airway Pressure (APAP) device with new technology called SensAwake™.
- Trial name
- NCT03294629
- Testing
- SensAwake™ modification
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Sleep Disorders, Obstructive Sleep Apnea
Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression
The primary objective of the study is to evaluate whether armodafinil at a target dosage of 200 mg/day is more effective than placebo treatment in improving excessive sleepiness in patients with obstructive sleep apnea/hypopnea…
- Conditions
- Sleep Disorders, Obstructive Sleep Apnea, Major Depressive Disorder, Dysthymic Disorder
- Trial name
- NCT00518986
- Testing
- armodafinil
- Where
- 62 sites in United States
- Volunteers
- 249 people
- Sponsor
- Cephalon
Obstructive Sleep Apnea, Diabetes Mellitus, Type 2
Correlation Between Nocturnal Oxygen Desaturation and Glycemic Control in Diabetic Patients With Obstructive Sleep Apnea
Nocturnal reduction in blood oxygen is expected independently associated with the development of worsened glycemic control in individuals with type 2 diabetes mellitus.
- Trial name
- NCT04711083
- Testing
- overnight pulse oximetry
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Ain Shams University
Sleep Apnea, Obstructive, Obstructive Sleep Apnea Syndrome
Usefulness of a Telemedicine System for OSA Patients Follow-up With High Cardiovascular Risk
The aim of this study is to determine the usefulness of a telemedicine system for the follow-up of OSA patients with a high cardiovascular risk.
- Trial name
- TELESAS (NCT01226641)
- Testing
- Telemedicine, Standard care
- Where
- 14 sites in France
- Volunteers
- 107 people
- Sponsor
- Initiative Pour la Sante
Obstructive Sleep Apnea
Home Diagnosis and Treatment of Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is a common and underrecognised condition. The diagnosis of OSA is typically made after an in-lab polysomnography (PSG) which requires an overnight stay in a sleep laboratory.
- Trial name
- NCT00139022
- Testing
- Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Obstructive Sleep Apnea of Adult
An Extension Study to Assess the Long-term Safety of the Genio® System
The objective of this study is to assess the long-term safety of the Genio® system in adult OSA patients with and without complete concentric collapse of the soft palate who have successfully been implanted with the Genio IS in a…
- Trial name
- OLE (NCT05939141)
- Testing
- Genio System
- Where
- 7 sites in Australia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Nyxoah S.A.
Obstructive Sleep Apnea
Effectiveness of Compression Stocking on Overnight Fluid Shift in Obstructive Sleep Apnoea Patients
Overnight rostral fluid shift is one of the contributing factors for worsening obstructive sleep apnoea (OSA). Fluid shift has been recognized to play a role in the pathophysiology of sleep apnoea.
- Trial name
- NCT04917094
- Testing
- Compression stocking
- Where
- Singapore
- Volunteers
- 29 people
- Sponsor
- Khoo Teck Puat Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives
OSANOVA is a non-randomized clinical trial which aims to compare outcomes of mandibular advancement device (MAD) and hypoglossal nerve stimulation (HGNS) therapies in moderate-to-severe OSA patients who fail, decline, or are…
- Trial name
- OSANOVA (NCT07074288)
- Testing
- MAD, HGNS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related
Bruxism Induced by Obstructive Sleep Apnoea.
The relationship between obstructive sleep apnea (OSA), sleep bruxism, and temporomandibular disorders is becoming clearer, but data on how upper airway volume affects bruxism due to OSA is limited.
- Conditions
- Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related, Upper Respiratory Tract Illness
- Trial name
- OSA Bruxism (NCT07511946)
- Testing
- Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT) and Polysomnography, Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Obstructive Sleep Apnea
Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic…
- Trial name
- NCT01800786
- Testing
- CPAP
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Obstructive
Treatment Study of Soft Palatal Implants in Obstructive Sleep Apnea
The purpose of the study is to compare the effectiveness of soft palatal implants with placebo and continuous positive airway pressure treatment in obstructive sleep apnea.
- Trial name
- NCT00263770
- Testing
- soft palate implant, Positive airway pressure (PAP)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea, Osa Syndrome
Tonsillectomy and Expansion Sphincter Pharyngoplasty Operations
Background: To compare the efficacy of tonsillectomy and expansion sphincter pharyngoplasty (ESP) in the surgical treatment of obstructive sleep apnea (OSA).
- Trial name
- NCT06119841
- Testing
- Tonsillectomy, Expansion sphincter pharyngoplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Saglik Bilimleri Universitesi
Sleep Apnea, Obstructive
Biological and Cognitive Marker of Neurodegeneration in Obstructive Sleep Apnea Patients
The goal of this observational study is to investigate biomarkers and neurocognitive markers of neurodegenerative processes in obstructive sleep apnea patients.
- Trial name
- NCT06167369
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Technische Universität Dresden
Epilepsy, Obstructive Sleep Apnea
Investigation of Sleep Quality and Prevalence of Sleep-disordered Breathing in Children and Young People With Epilepsy
Obstructive sleep apnoea (OSA) is a condition that affects around one in 20 children. In children with OSA, repeated episodes of airway obstruction can severely disturb and fragment sleep, leading to subsequent cognitive and…
- Trial name
- NCT03103841
- Testing
- Sleep studies [Polysomnography]
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Obstructive Sleep Apnea, Surgery
Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
Patients with obstructive sleep apnea (OSA) are at increased risk of developing sleep disturbances after surgery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, analgesic, and anxiolytic effects.
- Conditions
- Obstructive Sleep Apnea, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06566482
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Overhydration
Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients
The purpose of this study is to investigate the effect of decreasing fluid overload by hemodialysis on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease on intermittent hemodialysis.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease
- Trial name
- SASinHD (NCT01860209)
- Testing
- Hemodialysis
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois