Clinical trials: OSA - Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA)
Intermittent-Hypoxia Inhibits Neutrophil Extracellular Traps Formation: Role of Cathelicidins
The study will enroll 80 moderate-to-severe Obstructive sleep apnea (OSA) patients (40 obese) and 40 age-, gender-, and body mass index-matched controls.
- Trial name
- NCT07129486
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kun-Ta Chou
Snoring, Obstructive Sleep Apnea (OSA)
Validation of a Snoring App Against Commercially Available Applications and PSG
This study will compare the output of a new snoring application against another commercially available application and polysomnography (either home or in-laboratory).
- Trial name
- NCT07097597
- Testing
- Comparison 1: New Snoring Application, Comparison 2: Commercially Available Snoring Application, Comparison 3: Polysomnography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA)
Validating a Novel Driving Simulation-based MWT Against the Standard MWT in an OSA-cohort Challenged by CPAP-withdrawal
In brief, the proposed study will evaluate a recently proposed naturalistic, driving simulation test to identify and measure sleepiness behind the wheel, one of the most underestimated causes of road accidents.
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA), CPAP Treatment, Driving Simulator Performance
- Trial name
- DS-MWT2 (NCT06872593)
- Testing
- CPAP-withdrawal, Test Sequence
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Stefan Lakämper
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Obstructive Sleep Apnea, OSA
Predictability of OSA With a Subjective Screening Scale (OSASSS1)
the study aims to evaluate the accuracy correlation between subjective perception of the air flow through airways from patients and survey and/or polysomnography they spent, using a brief clinical protocol they answered with a…
- Trial name
- OSASSS1 (NCT06092710)
- Testing
- neuro-sensorial subjective evaluation of the airways collapsibility
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Center for Sleep Medicine - Clinique André Renard
OSA
Continuation Protocol for Obstructive Sleep Apnea (OSA)
The combination drug composed of aroxybutynin and atomoxetine, designated AD109, is being developed by Apnimed for the treatment of obstructive sleep apnea (OSA).
- Trial name
- NCT06566820
- Testing
- Aroxybutynin and Atomoxetine
- Where
- 99 sites in United States, Canada
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- Apnimed
Obstructive Sleep Apnea (OSA), OSA
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
The investigators will establish how well a novel, quick, and painless way of measuring muscle activity from the mouth and throat works for detecting sleep apnea.
- Conditions
- Obstructive Sleep Apnea (OSA), OSA, Healthy Volunteers, Electromyography
- Trial name
- NCT06944782
- Testing
- Electromyography (EMG) of the Oropharynx
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea (OSA)
Safety and Tolerability of Gefapixant (MK-7264) in Participants With Obstructive Sleep Apnea (MK-7264-039)
The purpose of this study is to assess the safety and tolerability of multiple dose administration of gefapixant (MK-7264) in participants with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT03882801
- Testing
- Gefapixant
- Where
- 5 sites in United States, Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea (OSA)
Development of Advanced Leak Detection Technologies for Positive Airway Pressure Devices Therapies
This study will take between 1-2 months (with first patient first visit to last patient last visit). Each participant will use the supplied PAP device and mask for a period of up to 14 nights.
- Trial name
- NCT04741854
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ResMed
OSA, OSAS
Maxillomandibular Advancement in the Treatment of Obstructive Sleep Apnea
ABSTRACT OBJECTIVES: To study the correlation between pharyngeal airway volume (PAV), the clinical indicators of obstructive sleep apnea (AHI, ESS), and the impact of orthognathic surgery on them.
- Conditions
- OSA, OSAS, Apnea, Obstructive Sleep, Orthognathic Surgery
- Trial name
- NCT03796078
- Testing
- Maxillomandibular advancement, monomaxillary surgery (isolated MaxS), monomandibullary surgery (MandS)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centro Medico Teknon
OSA
Attitudes Toward Obstructive Sleep Apnea-Related Cause of Road Traffic Accidents in Thailand Through Well Prepared Educational Video
The goal of this descriptive, cross-sectional survey design is to determine the effect of public awareness video on the basic knowledge regarding sleep apnea syndrome or glaucoma and traffic accidents in normal population The…
- Trial name
- AOSARTA (NCT05734742)
- Testing
- Educational video
- Where
- Thailand
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
OSA
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
This prospective observational study will enroll 60 moderate-to-severe OSA patients (AHI≧15/hour, 30 obese [BMI>=27] \& 30 non-obese [BMI<27]) and 40 age-, gender-, BMI-matched controls without OSA.
- Trial name
- NCT05485688
- Testing
- sleep apnea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Obstructive Sleep Apnea (OSA)
Effects of Audiovisual Distraction on Desaturation and Airway Intervention in OSA-patients
Patients will be randomly assigned to either one of two groups: 1. Standard of care sedation 2. Audiovisual distraction during surgery and in the recovery room using video goggles and headphones; patients can choose a movie from…
- Trial name
- AVD (NCT03020914)
- Testing
- Audiovisual Distraction
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Obstructive Sleep Apnea (OSA)
Evaluating the Efficacy of PAP Therapy for Treating OSA in the Home Environment
This study will take between 4-6 months (with first patient first visit to last patient last visit expected to span 3-4 months across all study sites).
- Trial name
- NCT04744038
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- 2 sites in United States, Australia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea (OSA)
Tailored Treatment to Enhance Risk Perception in Sleep Apnea
Obstructive Sleep Apnea (OSA) is seen in approximately 6% of Americans. It is a serious medical condition with significant medical and psychological consequences, including diabetes, hypertension, and cardiovascular disease.
- Trial name
- NCT02314858
- Testing
- Brief Personalized Video (BPV), Non-Personalized Video (NPV), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
OSA, Proteinuria
The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children
The presence of protein in urine is a common laboratory finding in children. Although proteinuria is usually benign, it can be a marker of a serious underlying renal disease or systemic disorder.
- Conditions
- OSA, Proteinuria, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT03933046
- Testing
- PSG
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obstructive Sleep Apnea (OSA)
Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment
Our group has recently found that the choice of positive airway pressure mask can significantly affect the pressure required to adequately treat sleep disordered breathing.
- Trial name
- Mask_MRI (NCT01939938)
- Testing
- Nasal and Oronasal PAP Mask
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA)
Brain During Effort : Effects of Hypoxia With Respiratory Patients
Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow (CBF), the modification of one or the other can affect the neuronal O2 availability.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA), Healthy Volunteers
- Trial name
- NEUROX (NCT02854280)
- Testing
- Pedalling exercise on a cycle ergometer, Isolated contractions of the quadriceps
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea (OSA)
Differences in Efficacy Between Nasal and Oronasal Masks in the Treatment of OSA With CPAP
Our group previously conducted a study looking at the performance of three styles of positive airway pressure masks during laboratory treatment studies for obstructive sleep apnea, and we found that patients using a full-mask…
- Trial name
- NCT01909674
- Testing
- Switch CPAP mask type
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Disease (CAD), Obstructive Sleep Apnea (OSA)
Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive…
- Trial name
- NCT02624297
- Testing
- Aerobic exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital