Clinical trials: OA, open to volunteers
Knee Osteoarthritis, Knee Osteoarthritis (OA)
Knee Osteoarthritis and Spa Therapy
The aim of this clinical trial is to assess the efficacy of the 18-day balneotherapy program (therapeutic indication: Rheumatology) in terms of functional incapacity and the disorders (pain, joint stiffness) induced by…
- Trial name
- SANTIAGO (NCT06617975)
- Testing
- Balneotherapy program in rheumatology indication
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CEN Biotech
Knee Osteoarthritis
The Effect of Theory-driven Physiotherapy on Physical Activity in Knee OA.
Knee osteoarthritis (OA) is a leading cause of pain, disability, and reduced physical functioning worldwide. Although physiotherapy and physical activity are recommended as first-line treatments, many individuals with knee OA do…
- Trial name
- EXPLOR (NCT07901881)
- Testing
- EXPLOR-3
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Mark van Loo
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Rehabilitation, Excercise
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.
The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis.
- Conditions
- Rehabilitation, Excercise, Geriatric, Physical Therapy
- Trial name
- 5Ms/PT/KOA/OA (NCT07640529)
- Testing
- Geriatric 5Ms framework, Exercises PT
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Saud University
Rheumatoid Arthritis, Osteoarthritis
Effect of Exercise Type on Muscle Quality in Patients With OA, SARC and RA: an Explorative Study
C4M hypothesizes that patients with low muscle strength may respond differently to different types of exercise intervention, dependent on the underlying aetiology, i.e.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Sarcopenia
- Trial name
- C4M (NCT06480643)
- Testing
- High load exercise type, Low load exercise type
- Volunteers
- 69 people
- Sponsor
- Amsterdam UMC, location VUmc
Osteoarthritis (OA) of the Knee
The Effects of Knee Brace and Muscle Training on Osteoarthritis Patients
A new non-weight-bearing knee brace has been developed to correct abnormal alignment and reduce joint pressure, showing promising results in alleviating knee osteoarthritis symptoms compared to traditional braces.
- Trial name
- NCT07246109
- Testing
- knee brace
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Cartilage Injury, OA Knee
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.
- Trial name
- NCT07094100
- Testing
- Tissue engineered cartilage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Knee Osteoarthritis
ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA
The aim of this study is to conduct a comparative evaluation of the ROAM OA Single Upright Brace and the Ossur Unloader One Knee Brace in subjects with medial compartment osteoarthritis.
- Trial name
- NCT07224958
- Testing
- ROAM OA Single Upright Knee Brace, Ossur Unloader One Knee Brace or Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Osteoarthritis (OA) of the Knee
Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty
The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a…
- Trial name
- NCT07219888
- Testing
- oral suzetrigine, oral Oxycodone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Louisville
Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty
GENicular Nerve Block in KNEE Arthroplasty
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty, Genicular Nerve Block
- Trial name
- GENKNEE (NCT07589127)
- Testing
- Preoperative genicular nerve block (GNB)
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Helse Møre og Romsdal HF
Shoulder Osteoarthritis
PRP for Glenohumeral Osteoarthritis
The glenohumeral joint is the third most common large joint to be affected by OA. Conservative treatments include physical activity, corticosteroid injections, and medications.
- Trial name
- NCT05675527
- Testing
- Low-dose PRP, High-dose PRP, Saline
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis (OA) of the Knee, Neuromodulation
Percutaneous Neurostimulation in Knee Osteoarthritis
Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals.
- Trial name
- NCT07637682
- Testing
- nerve stimulation using a nerve stimulator to the genicular nerve, nerve stimulation using a nerve stimulator to the saphenous nerve
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer
Knee Arthritis Osteoarthritis
Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities
This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis.
- Trial name
- HILT-CM (KOA) (NCT07551245)
- Testing
- High-Intensity Laser Therapy (HILT), Conventional Physical Therapy Modalities
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Erbil Polytechnic University
Knee Osteoarthritis (Knee OA)
A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
1. Study Objective To Explore the Efficacy and Evaluate the Safety of Vutiglabridin in Knee Osteoarthritis Patients 2. Background Glaceum Inc.
- Trial name
- NCT06845553
- Testing
- Vutiglabridin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Glaceum
Osteoarthritis (OA) of the Hip
Gait After THA: Direct Anterior vs Manual Posterior vs Robotic Posterior
The purpose of this study is to evaluate the gait biomechanics following THA on 3 groups of subjects undergoing DAA (manual) and PA (manual and robotic) surgical approaches.
- Trial name
- NCT07226973
- Testing
- Total hip arthroplasty via direct anterior approach (manual, non-robotic), Total hip arthroplasty via posterior approach (manual, non-robotic), Robotic-assisted total hip arthroplasty via posterior approach
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ochsner Health System
Arthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right Thumb
Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis
The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain.
- Trial name
- NCT06359665
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brent DeGeorge
Osteoarthritis, Knee, Osteoarthritis
Phase 4 Study of Laybon Tab. in Knee Osteoarthritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis.
- Trial name
- NCT07203547
- Testing
- Layla Tab., Laybon Tab.
- Volunteers
- 172 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Knee Arthritis Osteoarthritis
An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis
StromaForte injection for knee OA
- Trial name
- NCT07542808
- Testing
- Mesenchymal Stem Cells (MSC), Hyaluronic Acid (HA)
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Cellcolabs Clinical SPV Limited